Selenium Alleviates Chromium(VI)-Induced Ileum Damage and Cecal Microbial Disturbances in Mice

Zhao, Yanbing; Zhang, Huan; Hao, Dezheng; Wang, Jinglu; Zhang, Ding; Sun, Zilong; Liu, Ci

doi:10.1007/s12011-021-03061-x

Cited by 3 publications

(3 citation statements)

References 47 publications

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“…The literature data and our previous research report that exposure to vitamin E and ETS promotes the accumulation of GSH pool in liver of rats [14,19]. Non-enzymatic antioxidant GSH reduces the intensity of Cr(VI) accumulation in liver by binding to the corresponding heavy metal with subsequent formation of biologically inert complexes [42]. GSH-Cr(VI) complexes are reduced to GSH-Cr(III), which are subsequently excreted from the body through the kidneys [5].…”

Section: Resultsmentioning

confidence: 95%

Effect of ethylthiosulfаnylate in combination with vitamin E on certain biochemical blood parameters and hematological indicators in rats under the influence of Cr(VI)

Kotyk¹

2023

Bìol. Tvarin

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The aim of our study was to investigate the effect of ethylthiosulfаnylate, a representative of the class of thiosulfonate compounds, in combination with vitamin E on certain biochemical blood parameters, hematological indicators and total Chromium content in liver of rats exposed to Cr(VI). Laboratory rats were divided into 8 groups of 5 animals each. Animals of group I (intact control) were injected daily intraperitoneally with 150 μl of physiological saline solution for 7 days. Rats of III/IV groups received intraperitoneal daily administration of K2Cr2O7 (diluted in physiological saline solution at a dose of 2.5 mg Cr(VI)/kg) for 7/14 days. Animals of the II experimental group were injected daily intragastrically with 1000 μl of sunflower oil for 14 days. Rats of V/VI experimental groups were administrated daily intragastrically with 1000 μl of an oil solution of vitamin E (20 mg/kg)/vitamin E (20 mg/kg) in combination with ethylthiosulfаnylate (100 mg/kg) for 14 days. Animals of VII/VIII experimental groups were injected daily intragastrically with 1000 μl of an oil solution of vitamin E (20 mg/kg) in combination with ethylthiosulfаnylate (100 mg/kg) for 14 days, after which a 7-day/14-day period of intraperitoneal K2Cr2O7 administration was performed. Exposure to Cr(VI) led to a decrease in the number of erythrocytes, leukocytes, content of hemoglobin, phospholipids, total protein against the background of the accumulation of total lipids, mono- and diglycerides, non-esterified fatty acids, and creatinine in blood of rats. Chromium concentration significantly increased in the liver of rats after administration of Cr(VI). The combined effect of vitamin E and ethylthiosulfаnylate contributed to the partial compensation of Cr(VI)-induced disturbances of the number of leukocytes and content of total proteins, phospholipids, non-esterified fatty acids in blood of rats. Vitamin E and ethylthiosulfаnylate pretreatment also contributed to the reduction of the percentage accumulation of Chromium in liver of rats injected with Cr(VI).

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Section: Resultsmentioning

confidence: 95%

Effect of ethylthiosulfаnylate in combination with vitamin E on certain biochemical blood parameters and hematological indicators in rats under the influence of Cr(VI)

Kotyk¹

2023

Bìol. Tvarin

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“…Moreover, it was observed that long-term exposure to Cr(VI) promotes the development of colon cancer in mice, which is attributed to modifications in the gut microbiota and the occurrence of oxidative stress (Zhang et al, 2020). In their studies involving mice, Zhao et al (2022) demonstrated that the pathological effect of Cr(VI) on the microflora of the ileum and cecum can be effectively mitigated by Se treatment. Studies on mice found that intestinal bacteria can compete with the host for Se where its availability is limited (Hrdina et al, 2009).…”

Section: Essentaial Mineralsmentioning

confidence: 99%

Bioactive compounds, antibiotics and heavy metals: Effects on the intestinal structure and microbiome of monogastric animals – a non-systematic review

Winiarska-Mieczan

Kwiecień

Jachimowicz

et al. 2023

Annals of Animal Science

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The intestinal structure and gut microbiota are essential for the animals‘ health. Chemical components taken with food provide the right environment for a specific microbiome which, together with its metabolites and the products of digestion, create an environment, which in turn is affects the population size of specific bacteria. Disturbances in the composition of the gut microbiota can be a reason for the malformation of guts, which has a decisive impact on the animal‘ health. This review aimed to analyse scientific literature, published over the past 20 years, concerning the effect of nutritional factors on gut health, determined by the intestinal structure and microbiota of monogastric animals. Several topics have been investigated: bioactive compounds (probiotics, prebiotics, organic acids, and herbal active substances), antibiotics and heavy metals (essentaial minerals and toxic heavy metals).

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“…Thiosulfonates are used in industrial processes as stabilizers, antioxidants, pH regulators, corrosion inhibitors, and more. They can be employed in the production of plastics, paints, detergents, pharmaceuticals, and other products [24].…”

Section: Introductionmentioning

confidence: 99%

The role of oil solutions of thiosulfonates in the modulation of antioxidant parameters in rat kidneys

Liubas,

Oliynyk

2023

Bìol. Tvarin

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This study investigated the influence of thiosulfonate esters, specifically S-ethyl-4-aminobenzenethiosulfonate (ETS), S-allyl-4-aminobenzenethiosulfonate (ATS), and S-allyl-4-acetylaminobenzenethiosulfonate (AATS), at a dose of 50 mg/kg body weight on the antioxidant defense system in rat kidneys. The kidneys are essential organs involved in maintaining metabolic homeostasis and they are constantly exposed to reactive oxygen species (ROS) and oxidative stress. The effectiveness of the antioxidant defense system was evaluated by measuring oxidative stress markers, including lipid peroxidation (LPO), as well as the activity of key antioxidant enzymes, such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GP), glutathione reductase (GR), and the level of reduced glutathione (GSH). Dysfunction of oxidant protection was observed with an oily diet, characterized by an increase in lipid hydroperoxide levels, a decrease in the SOD and catalase activity, and a decrease in the antioxidant activity of the entire glutathione chain. Administration of thiosulfonates, especially ETS and AATS, helped stabilize antioxidant protection. The beneficial antioxidant effects of thiosulfonates can be partially explained by their ability to prevent the formation of free radicals, can intercept, neutralize reactive oxygen species and other harmful substances that can damage body cells.

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Selenium Alleviates Chromium(VI)-Induced Ileum Damage and Cecal Microbial Disturbances in Mice

Cited by 3 publications

References 47 publications

Effect of ethylthiosulfаnylate in combination with vitamin E on certain biochemical blood parameters and hematological indicators in rats under the influence of Cr(VI)

Effect of ethylthiosulfаnylate in combination with vitamin E on certain biochemical blood parameters and hematological indicators in rats under the influence of Cr(VI)

Bioactive compounds, antibiotics and heavy metals: Effects on the intestinal structure and microbiome of monogastric animals – a non-systematic review

The role of oil solutions of thiosulfonates in the modulation of antioxidant parameters in rat kidneys

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