Selenium and Colorectal Adenoma: Results of a Pooled Analysis

Jacobs, Elizabeth T.; Jiang, Ruixuan; Alberts, David S.; Greenberg, E. Robert; Gunter, Elaine W.; Lanza, Elaine; Ratnasinghe, Luke D.; Reid, Mary E.; Schatzkin, Arthur; Smith‐Warner, Stephanie A.; Wallace, Kristin; Martı́nez, Marı́a Elena

doi:10.1093/jnci/djh310

Cited by 141 publications

(85 citation statements)

References 22 publications

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“…Selenium intake or levels have been linked with various neoplasms, such as prostate (14), colorectal (15) and lung (16). In an area of China with low serum selenium concentrations, low serum selenium was associated with death from esophageal cancer and stomach cancer (17).…”

Section: Discussionmentioning

confidence: 99%

Low plasma selenium concentrations and mortality among older community-dwelling adults: the InCHIANTI Study

Lauretani

Semba²,

Bandinelli

et al. 2008

Aging Clin Exp Res

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Aims-We examined the relationship between plasma selenium levels at enrollment and all-cause mortality over a 6-year period among participants in the InCHIANTI study.Methods-1042 men and women ≥65 years from the InCHIANTI study, a population-based study of older adults living in the Chianti region of Tuscany, a population-based cohort in Tuscany, Italy. Plasma selenium was measured at enrollment (1998)(1999)(2000), and vital status was ascertained until May 2006.Results-During follow-up, 237 participants (22.7%) died. At enrollment, mean (SD) plasma selenium concentrations among participants who survived or died were 0.96 (0.14) and 0.87 (0.18) µmol/L (p<0.0001), respectively. The proportion of participants who died, from lowest to highest quartile of selenium, was 41.3, 27.0, 18.1 and 13.5% (p<0.0001 by Mantel-Haenszel chi-square). After adjusting for age, sex, education, and chronic diseases, adults in the lowest quartile of plasma selenium at enrollment had higher mortality compared with those in the highest quartile (Hazard Ratio (HR) 1.60, 95% Confidence Interval (CI) 1.04-2.47, p=0.034).Conclusion-Low plasma selenium may be an independent predictor of mortality among older adults living in the community.

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Section: Discussionmentioning

confidence: 99%

Low plasma selenium concentrations and mortality among older community-dwelling adults: the InCHIANTI Study

Lauretani

Semba²,

Bandinelli

et al. 2008

Aging Clin Exp Res

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“…Die Korrelation niedriger Selen-Konzentrationen im Serum mit einem erhöhten Adenomrisiko ist nicht ausreichend, um eine Empfehlung zur Selensupplementierung auszusprechen [77,78].…”

Section: Empfehlung 2013unclassified

S3-Leitlinie – Kolorektales Karzinom

Schmiegel

Buchberger

Follmann³

et al. 2017

Z Gastroenterol

151

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“…Cancer mortality is inversely correlated with estimated Se intake [8,29]. Low Se intake or low plasma Se concentrations are associated with increased risk of colorectal cancer (CRC) [7,25] whereas in contrast, higher Se status is associated with lower risk of a recurrence of colonic tumours [15]. In the United States, daily supplementation with 200 lg Se has been found to lead to reduced mortality from CRC [6].…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer

et al. 2010

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Selenium (Se), a dietary trace metal essential for human health, is incorporated into *25 selenoproteins including selenoprotein S (SelS) and the 15-kDa selenoprotein (Sep15) both of which have functions in the endoplasmic reticulum protein unfolding response. The aim of this study was to investigate whether genetic variants in such selenoprotein genes are associated with altered risk of colorectal cancer (CRC). A Korean population of 827 patients with CRC and 733 healthy controls was genotyped for 7 SNPs in selenoprotein genes and one SNP in the gene encoding manganese superoxide dismutase using Sequenom technology. Multivariate logistic regression analysis showed that after adjustment for lifestyle factors three SNP variants were associated with altered disease risk. There was a mean odds ratio of 2.25 [95% CI 1.13,4.48] in females homozygous TT for rs34713741 in SELS with the T variant being associated with higher risk of rectal cancer, and odds ratios of 2.47 and 2.51, respectively, for rs5845 and rs5859 in SEP15 with the minor A and T alleles being associated with increased risk of male rectal cancer. The data indicate that the minor alleles for rs5845, rs5859 and rs34713741 are associated with increased rectal cancer risk and that the effects of the three SNPs are dependent on gender. The results highlight potential links between Se, the function of two selenoproteins involved in the protein unfolding response and CRC risk. Further studies are required to investigate whether the effects of the variants on CRC risk are also modulated by dietary Se intake.

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Selenium and Colorectal Adenoma: Results of a Pooled Analysis

Abstract: The inverse association between higher blood selenium concentration and adenoma risk supports previous findings indicating that higher selenium status may be related to decreased risk of colorectal cancer.

Cited by 141 publications

References 22 publications

Low plasma selenium concentrations and mortality among older community-dwelling adults: the InCHIANTI Study

Low plasma selenium concentrations and mortality among older community-dwelling adults: the InCHIANTI Study

S3-Leitlinie – Kolorektales Karzinom

Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer

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