Selenium and l-Carnitine Reduce Oxidative Stress in the Heart of Rat Induced by 2.45-GHz Radiation from Wireless Devices

Türker, Yasin; Nazıroğlu, Mustafa; Gümral, Nurhan; Çelik, Ömer; Saygın, Mustafa; Çömlekçi, Selçuk; Flores-Arce, Manuel

doi:10.1007/s12011-011-8994-0

Cited by 37 publications

(12 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, the effectiveness of some antioxidants for mitigation of RFR exposure effects was demonstrated. Such protective effects have been reported for melatonin [21][22][23][24][25], vitamin E and C [26,27], selenium and L-carnitine [28].…”

Section: Introductionsupporting

confidence: 53%

Monochromatic red light of LED protects embryonic cells from oxidative stress caused by radiofrequency radiation

Tsybulin¹,

Sidorik²,

Kyrylenko³

et al. 2016

Oxid Antioxid Med Sci

View full text Add to dashboard Cite

Objective: Oxidative mechanisms of the mutagenic and carcinogenic potential of radiofrequency radiation (RFR) have been demonstrated recently. This opens the need for antioxidative approach for protection of living cells from harmful effects of RFR. In this study, we aimed to assess the antioxidant potential of monochromatic red light of light-emitting diodes (LED) in RFR-exposed embryonic cells. Methods: One group of Japanese quail embryos was exposed in ovo to GSM 900 MHz RFR (I = 1 14 µW/cm2; SAR = 0.17 mW/kg; t = 158 h; discontinuously) before and during the first hours of incubation. The second group of embryos was exposed to RFR in the same regimen and additionally to LED red light (λmax = 630-650 nm; I = 0.1 mW/cm2; t = 180 c; discontinuously). The third group of embryos were served as control. The rate of somitogenesis, level of lipid peroxidation, activity of superoxide dismutase (SOD) and catalase in tissues of 38-h embryos were assessed. Results: Red light of LED exposure resulted in statistically significant reversion of the rate of somitogenesis decreased under RFR exposure; as well as in reversion of significantly increased level of lipid peroxidation and decreased catalase activity in tissues of RFR exposed embryos. In vitro significant suppression of SOD and catalase activities by short-term RFR exposure were partially reversed by LED red light treatment. Conclusion: Red light of LED can protect embryonic cells from oxidative stress caused by low intensity RFR exposure. This is of particularly importance in terms of potential mutagenicity and carcinogenicity of low intensity RFR, which in turn depends on the oxidative potential of RFR.

show abstract

Section: Introductionsupporting

confidence: 53%

Monochromatic red light of LED protects embryonic cells from oxidative stress caused by radiofrequency radiation

Tsybulin¹,

Sidorik²,

Kyrylenko³

et al. 2016

Oxid Antioxid Med Sci

View full text Add to dashboard Cite

show abstract

“…Gumral et al, 2009; Türker et al, 2011. Nazıroğlu et al 2012 observed proliferative effects of 2.45 GHz EMR on human leukaemia cancer cells through the overproduction of reactive oxygen species (ROS) and Ca 2 + influx [9][10][11]. In addition, Aynali et al (2013) showed that WIFI (2.45 GHz) EMR (for 1 h/day for 30 days) increased lipid peroxidation levels in laryngotracheal mucosal tissues of rats [12].…”

Section: Introductionmentioning

confidence: 99%

Effect of Radiofrequency Waves Emitted From Conventional WIFI Devices on Some Oxidative Stress Parameters in Rat Kidney

Fahmy¹,

Mohammed²,

Abdelrahman³

et al. 2015

J Drug Metab Toxicol

View full text Add to dashboard Cite

Wireless Fidelity (WIFI) is widely used in cell phones, computers and electronic devices to access the Internet. It is unclear whether or not the frequency range of the WIFI has any harmful biological effects. In this report, the effect of standard 2.45 GHz radio frequency source (Averaged whole body specific absorption rate (SAR) 0.01 W/ Kg, 24 hours daily for 40 successive days) on some oxidative stress parameters was examined in Wistar female rats. We found that exposure to WIFI decreased the malondialdehyde levels as well as the glutathione-S-transferase and catalase activities. Moreover, the activity of superoxide dismutase showed significant increase in the WIFIexposed group relative to the control group. Meanwhile, kidney functions were found to be unaffected. In addition, no significant histological alterations in rats' kidneys were detected in WIFI-exposed group. These results indicate that WIFI exposure used in the present study implies oxidative alterations in rat kidneys, which does not result in severe consequences due to the effective activity of the antioxidant enzyme system of the rat kidneys.

show abstract

“…In the irradiated rats treated with LC 1.5 mg/kg b.w, i.p. concentrations of vitamins E were higher than in those rats that were only exposed to 2.45-GHz radiation [106]. Furthermore, metabolomics analysis shows that α-tocopherol deficiency in rats was associated with a compensatory increase in carnitine content in the liver [107].…”

Section: Sparing Effects Of Carnitine On Vitamin Ementioning

confidence: 89%

Carnitine Enigma: From Antioxidant Action to Vitagene Regulation. Part 2. Transcription Factors and Practical Applications

Surai¹

2015

J Vet Sci Med

View full text Add to dashboard Cite

A growing interest has been shown in the potential uses of carnitine in medical practice and animal/poultry industry. The molecular mechanisms accounting for the positive effect of LC on livestock animals are not yet fully understood but many protective effects of LC in various stress conditions reported in literature, have been related to its antioxidant action. Based on the analysis of the recent publications presented in the review it could be concluded that antioxidant actions of carnitine are associated to much extent with redox signaling in the cell. Indeed, LC is shown to upregulate Nrf2 and PPARs and downregulates NF-κB leading to anti-apoptotic and anti-inflammation actions of carnitine. In fact, Nrf2-mediated synthesis of antioxidant enzymes, including SOD, GSH-Px, GR, GST and GSH, in response to carnitine supplementation could be a main driving force of antioxidant action of carnitine and its derivatives. Furthermore, LC and its derivatives are shown to affect vitagene networks resulting in increased adaptive ability to stresses via additional synthesis of protective molecules, including heat shock proteins (HO-1), upregulating sirtuins, thioredoxins and SOD. It seems likely that in biological system in vivo the interactions of the aforementioned mechanisms provide an important place for carnitine to be a crucial part of the integrated antioxidant systems of the animal and human body. Furthermore, direct scavenging ROS and chelating properties of carnitine would be very much relevant to the antioxidant system of the gut. Taking into account low carnitine content in grains and poultry and pig diet formulations with limited amounts of animal proteins, carnitine requirement and possible inadequacy in commercial poultry and pig nutrition should receive more attention. Furthermore, protective roles of carnitine in stress conditions of commercial poultry and pig production, including its immunomodulating properties, are of great importance. Therefore, a development of carnitine-containing antioxidant compositions supplying via drinking water seems to be an important way forward in decreasing the detrimental consequence of various stresses in poultry and pig production.

show abstract

Selenium and l-Carnitine Reduce Oxidative Stress in the Heart of Rat Induced by 2.45-GHz Radiation from Wireless Devices

Cited by 37 publications

References 31 publications

Monochromatic red light of LED protects embryonic cells from oxidative stress caused by radiofrequency radiation

Monochromatic red light of LED protects embryonic cells from oxidative stress caused by radiofrequency radiation

Effect of Radiofrequency Waves Emitted From Conventional WIFI Devices on Some Oxidative Stress Parameters in Rat Kidney

Carnitine Enigma: From Antioxidant Action to Vitagene Regulation. Part 2. Transcription Factors and Practical Applications

Contact Info

Product

Resources

About