Selenium and outcome in heart failure

Bömer, Nils; Beverborg, Niels Grote; Hoes, Martijn F.; Streng, Koen W.; Vermeer, Marloes; Dokter, Martin M; IJmker, Jan; Anker, Stefan D.; Cleland, John G.F.; Hillege, Hans L.; Lang, Chim C.; Ng, Leong L.; Samani, Nilesh J.; Tromp, Jasper; Veldhuisen, Dirk J. van; Touw, Daan; Voors, Adriaan A.; Meer, Peter van der

doi:10.1002/ejhf.1644

Cited by 103 publications

(130 citation statements)

References 37 publications

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“…Supportive measures aimed at improving selenoprotein biosynthesis in COVID-19 may enable a better redox control and fine-tuned response of the immune system [41]. It appears meaningful, timely, and promising to initiate population-wide measures trying to identify subjects with pre-existing Se deficits, not just as a preventive measure for viral infections, spread, and virulence development [11,12,42], but also to reduce the individual risk for cardiovascular mortality [44][45][46][47], cancer [21,48,49], and death from severe disease [10,14,39]. infections, spread, and virulence development [11,12,42], but also to reduce the individual risk for cardiovascular mortality [44][45][46][47], cancer [21,48,49], and death from severe disease [10,14,39].…”

Section: Discussionmentioning

confidence: 99%

Selenium Deficiency Is Associated with Mortality Risk from COVID-19

et al. 2020

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SARS-CoV-2 infections underlie the current coronavirus disease (COVID-19) pandemic and are causative for a high death toll particularly among elderly subjects and those with comorbidities. Selenium (Se) is an essential trace element of high importance for human health and particularly for a well-balanced immune response. The mortality risk from a severe disease like sepsis or polytrauma is inversely related to Se status. We hypothesized that this relation also applies to COVID-19. Serum samples (n = 166) from COVID-19 patients (n = 33) were collected consecutively and analyzed for total Se by X-ray fluorescence and selenoprotein P (SELENOP) by a validated ELISA. Both biomarkers showed the expected strong correlation (r = 0.7758, p < 0.001), pointing to an insufficient Se availability for optimal selenoprotein expression. In comparison with reference data from a European cross-sectional analysis (EPIC, n = 1915), the patients showed a pronounced deficit in total serum Se (mean ± SD, 50.8 ± 15.7 vs. 84.4 ± 23.4 µg/L) and SELENOP (3.0 ± 1.4 vs. 4.3 ± 1.0 mg/L) concentrations. A Se status below the 2.5th percentile of the reference population, i.e., [Se] < 45.7 µg/L and [SELENOP] < 2.56 mg/L, was present in 43.4% and 39.2% of COVID samples, respectively. The Se status was significantly higher in samples from surviving COVID patients as compared with non-survivors (Se; 53.3 ± 16.2 vs. 40.8 ± 8.1 µg/L, SELENOP; 3.3 ± 1.3 vs. 2.1 ± 0.9 mg/L), recovering with time in survivors while remaining low or even declining in non-survivors. We conclude that Se status analysis in COVID patients provides diagnostic information. However, causality remains unknown due to the observational nature of this study. Nevertheless, the findings strengthen the notion of a relevant role of Se for COVID convalescence and support the discussion on adjuvant Se supplementation in severely diseased and Se-deficient patients.

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Section: Discussionmentioning

confidence: 99%

Selenium Deficiency Is Associated with Mortality Risk from COVID-19

et al. 2020

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“…Supportive measures aimed at improving selenoprotein biosynthesis in COVID-19 may enable a better redox control and fine-tuned response of the immune system [38]. It appears meaningful, timely and promising to initiate population-wide measures trying to identify subjects with pre-existing Se deficits, not just as preventive measure for viral infections, spread and virulence development [11,12,39], but also to reduce the individual risk for cardiovascular mortality [41][42][43][44], cancer [21,45,46], and death from severe disease [10,14,36]. Infections by SARS-CoV-2 occur largely independent from baseline Se status.…”

Section: Discussionmentioning

confidence: 99%

Selenium Deficiency is Associated with Mortality Risk from COVID-19

Moghaddam

Heller

Sun

et al. 2020

Preprint

153

129

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SARS-CoV-2 infections underlie the current Coronavirus disease (COVID-19) pandemic and are causative for a high death toll particularly among elderly subjects and those with comorbidities. Selenium (Se) is an essential trace element of high importance for human health and particularly for a well-balanced immune response. Mortality risk from severe disease like sepsis or polytrauma is inversely related to Se status. We hypothesized that this relation also applies to COVID-19. Serum samples (n=166) from COVID-19 patients (n=33) were collected consecutively and analysed for total Se by X-ray fluorescence and selenoprotein P (SELENOP) by a validated ELISA. Both biomarkers showed the expected strong correlation (r=0.7758, p<0.001), pointing to an insufficient Se status for optimal selenoprotein expression. In comparison to reference data from a European cross sectional analysis (EPIC, n=1915), the patients showed a pronounced deficit in total serum Se (mean±SD, 50.8±15.7 vs. 84.4±23.4 µg/L) and SELENOP (3.0±1.4 vs. 4.3±1.0 mg/L). A Se status below the 2.5th percentile of the reference population, i.e., [Se] < 45.7 µg/L and [SELENOP] < 2.56 mg/L was present in 43.4% and 39.2% of COVID samples, respectively. The Se status was significantly higher in samples from surviving COVID patients as compared to non-survivors (Se; 53.3±16.2 vs. 40.8±8.1 µg/L, SELENOP; 3.3±1.3 vs. 2.1±0.9 mg/L). We conclude that Se status analysis in COVID patients provides diagnostic information. However, causality remains unknown due to the observational nature of this study. Nevertheless, the findings strengthen the notion on a relevant role of Se for COVID convalescence, and support the discussion on adjuvant Se supplementation in severely diseased and Se-deficient patients.

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“…В организме человека селен входит в состав порядка 30 биологически активных соединений (ферменты антиоксидантной системы, гормоны, липиды), участвует в метаболизме нуклеиновых кислот и регуляции действия тиреоидных гормонов [7][8][9]. Селен имеет важное значение для нормальной работы иммунной и антиоксидантной систем организма, защищающих от неблагоприятного воздействия окружающей среды, т. к. является необходимым компонентом системы, регулирующей количество свободных радикалов, которые образуются в организме физиологически, а также в результате патологических процессов [9,23].…”

Section: Discussionunclassified

“…Очевидно, что дефицит селена вызовет нарушение работы антиоксидантной системы и повреждение клеток организма свободными радикалами. Недостаточность селена может провоцировать патологию разных органов и систем, вызывать злокачественные заболевания [9,23,24]. Дефицит Se приводит к болезни Кашина-Бека (остеоартроз с множественной деформацией суставов, позвоночника и конечностей), болезни Кешана (эндемическая миокардиопатия), анемии, наследственной тромбастении [9,25].…”

Section: Discussionunclassified

Selenium Content in Spelt, Buckwheat, and Vegetable Pasta

Fazullina

Ponomareva

Смирнов

et al. 2020

Food Processing: Techniques and Technology

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Introduction. As a trace element, selenium is present in humans as part of selenoproteins. It improves the work of the antioxidant defense system and produces a strong immunomodulatory effect. Selenium is part of about 30 biologically active compounds of human body. However, selenium deficiency is considered a global problem. The research objective was to determine the selenium content in the developed pasta products. Study objects and methods. The study featured laboratory samples of pasta made from a mix of whole wheat spelt flour, buckwheat, and low-temperature drying powders of broccoli and celery. The selenium content was determined by atomic absorption spectroscopy with electrothermal atomization with a palladium nitric acid matrix modifier. The experiment employed a Hitachi 180-80 atomic absorption spectrophotometer. To determine the selenium content, the samples underwent wet mineralization in nitric and perchloric acids. Adding hydrogen peroxide and ethanol made it possible to convert selenium from inorganic and organic forms into selenite ions. Results and discussion. The research involved domestic natural raw materials. The components proved to be good sources of selenium, which means that they can be used to produce functional products. The selenium content ranged from 105.7 ± 22 mkg/kg to 302.5 ± 17 mkg/kg in the samples. Taking into account the loss of selenium during cooking, the selenium content in 100 g of the finished product ranged from 13.5% to 38.5 %. Conclusion. The developed pasta products proved excellent sources of selenium. The use of buckwheat flour and vegetable powders in the formulation of wholegrain spelt dough increased the selenium content in the pasta by 40.7–186.2 %. The obtained results can be used for tables of the chemical composition of Russian food products.

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Selenium and outcome in heart failure

Cited by 103 publications

References 37 publications

Selenium Deficiency Is Associated with Mortality Risk from COVID-19

Selenium Deficiency Is Associated with Mortality Risk from COVID-19

Selenium Deficiency is Associated with Mortality Risk from COVID-19

Selenium Content in Spelt, Buckwheat, and Vegetable Pasta

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