Selenium cleome droserifolia nanoparticles (Se-CNPs) and it's ameliorative effects in experimentally induced diabetes mellitus

Maksoud, H; Zaid, Omayma A.R. Abou; Elharrif, Mohamed G.; Omnia, M.A.; Alaa, E.A.

doi:10.1016/j.clnesp.2020.07.016

Cited by 13 publications

(5 citation statements)

References 34 publications

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“…The H. dulcis is rich in selenium, with important biological activities of antioxidation and scavenging of free radicals. Appropriate supplementation of selenium can effectively improve the insulin free‐radical defense system and metabolic function of endocrine cells, providing a basis for prevention and treatment of diabetes 22,23 …”

Section: Resultsmentioning

confidence: 99%

Hypoglycemic effect of low‐sugar juice derived from Hovenia dulcis on type 1 diabetes mellitus rats

et al. 2021

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BACKGROUND Fruit juice is usually rich in monosaccharides and disaccharides. A reverse osmosis separation machine was used to remove monosaccharides and disaccharides from Hovenia dulcis fruit juice, leaving behind most of the bioactive substances in a low‐sugar fruit juice (LSFJ), so as to provide a more effective treatment for diabetic patients. METHOD This study was carried out with type 1 diabetes mellitus model induced with high dose of streptozotocin (60 mg kg−1), and oral administration of LSFJ for 4 weeks. RESULTS LSFJ treatment led to significant gain in body weight and increased serum insulin level, insulin‐like growth factor‐1 level, blood urea nitrogen level, creatinine level, and hepatic glycogen level. Meanwhile, fasting blood glucose, fructosamine level, and glucose tolerance were also observably enhanced. Additional, LSFJ treatment significantly improved lipid metabolism, islet quality, and islet oxidative stress. The messenger RNA levels of glucose metabolism genes in the pancreas of diabetic rats decreased in the diabetes model group, whereas messenger RNA expression of these genes was significantly increased with LSFJ treatment. CONCLUSION These findings indicate that LSFJ can improve symptoms associated with type 1 diabetes mellitus. The research also suggests new strategies for diabetes prevention and treatment. © 2021 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Hypoglycemic effect of low‐sugar juice derived from Hovenia dulcis on type 1 diabetes mellitus rats

et al. 2021

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“…Therefore, the covering layer of plant-synthesized selenium nanoparticles is extremely critical from the point of view of their further medical use. SeNP packaging involves diversified functional groups and compounds, such as carboxyl groups [118,119], alcohol groups [120,121], phenolic groups [122], amines [123], amides [124], alkanes [120], aldehydes, ketones [125], esters [126,127], amino acids [114], tannins [123], flavonoids [117,[128][129][130], cannabinoids [131], proteins [132][133][134][135], polysaccharides [136,137], ascorbic acid [138], carbohydrates [135,139], polyphenols [140,141], terpenoids [142,143], sugars [144], alkaloids [145,146], glycosides [145], and saponins [146].…”

Section: By Plantsmentioning

confidence: 99%

Selenium Nanoparticles: Green Synthesis and Biomedical Application

Mikhailova

2023

Molecules

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Selenium nanoparticles (SeNPs) are extremely popular objects in nanotechnology. “Green” synthesis has special advantages due to the growing necessity for environmentally friendly, non-toxic, and low-cost methods. This review considers the biosynthesis mechanism of bacteria, fungi, algae, and plants, including the role of various biological substances in the processes of reducing selenium compounds to SeNPs and their further packaging. Modern information and approaches to the possible biomedical use of selenium nanoparticles are presented: antimicrobial, antiviral, anticancer, antioxidant, anti-inflammatory, and other properties, as well as the mechanisms of these processes, that have important potential therapeutic value.

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“…Group (9): Diabetic group was fed on cake supplemented with 2.5 percent of the diet's weight in samwa leaves powder. Group (10): Diabetic group was fed on cake supplemented with samwa leaves powder at a rate of 5% of the diet's weight. The rats' body weight and food consumption were measured weekly during the trial, and their general behavior was observed.…”

Section: Experimental Designmentioning

confidence: 99%

“…The Southern Sinai Bedouins decocted leaves and stems for the treatment of diabetes and were known as an antihyperglycemic medication [9]. For healing stomachaches, skin allergies, and open wounds, as well as having anticancer and hepatoprotective qualities and antidiabetic activities [10]. Hence, it prompted us to investigate the effect of stevia and samwa leaf powder products on some biochemical parameters and enzyme activities of diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

تأثير المنتجات المحتوية على أوراق الإستيفيا والسموة على الفئران المصابة بمرض السکر

الحليم¹,

الشاعر²,

ذکى³

et al. 2022

مجلة الاقتصاد المنزلي.جامعة المنوفية

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The goal of this study was to investigate how different concentrations (2.5 and 5%) of stevia (Stevia rebaudiana) and samwa (Cleome droserifolia) leaves products affected alloxan-induced diabetes complications in rats. Fifty male albino rats weighing 140±10 g were used in this study and divided into two main groups. The first group (5 rats) was kept as a negative (-ve) control group fed on the basal diet. In comparison, the second group (45 rats) was given alloxan (dose 150 mg/kg BW) to induce diabetes and divided into nine equal sub-groups (5 rats per each) as follows: subgroup (1) served as a positive (+ve) control group that was fed on a basal diet, while subgroups (2, 3, 4, 5) diabetic groups were fed on a basal diet and 2.5, 5% of biscuits and cake that were incorporated with stevia leaves products, respectively. While subgroups (6, 7, 8, 9) diabetic groups were fed on a basal diet, 2.5 and 5% of biscuits and cake were incorporated with samwa leaves, respectively. Blood glucose, liver enzymes, lipid profile, and kidney functions were determined. The results revealed that the blood glucose, liver enzymes, kidney functions, and lipid profile significantly decreased (P≤0.05) compared to the positive control group. In contrast, HDL-c level and insulin excretion were significantly improved. So, it could be concluded that adding tested products enhanced the biochemical parameters of diabetic rats.

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Selenium cleome droserifolia nanoparticles (Se-CNPs) and it's ameliorative effects in experimentally induced diabetes mellitus

Cited by 13 publications

References 34 publications

Hypoglycemic effect of low‐sugar juice derived from Hovenia dulcis on type 1 diabetes mellitus rats

Hypoglycemic effect of low‐sugar juice derived from Hovenia dulcis on type 1 diabetes mellitus rats

Selenium Nanoparticles: Green Synthesis and Biomedical Application

تأثير المنتجات المحتوية على أوراق الإستيفيا والسموة على الفئران المصابة بمرض السکر

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