Selenium Content in Soil and Wheat Grain in Bulgaria

Krustev, Stefan; Angelova, V.; Zaprjanova, Penka; Nankova, M.; Ivanov, K.

doi:10.31080/asag.2020.04.0888

Cited by 1 publication

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“…Our findings have to be attributed to the fact that Bulgaria, as well as most European countries, is among the low-Se areas on the world Se atlas. [23] It has to be noted that the observed suboptimal Se status in Bulgaria is under conditions of adequate iodine supple- mentation owing to the implementation of a national program of iodine supplementation. [28] This fact further highlights the prominent role of Se deficiency in the prevalence of ATD in Bulgaria.…”

Section: Discussionmentioning

confidence: 99%

“…[20,22] As reported by a recent study of the Se content in Bulgarian soils and wheat grain, Bulgaria appears to be among the low-Se areas on the world Se atlas. [23] Furthermore, scarce data is available for the Se status of the Bulgarian population and even less for patients with thyroid disorders. The largest study in Bulgaria conducted about 30 years ago estimated s-Se reference ranges for adults with electrothermal atomic absorption spectrophotometry (ETAAS).…”

Section: Introductionmentioning

confidence: 99%

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Serum selenium concentration in patients with autoimmune thyroid disease

Davcheva¹,

Kirova²,

Miteva³

et al. 2022

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Introduction: Selenium (Se) is one of the environmental factors with an essential role in the pathogenesis of autoimmune thyroid disease (ATD). Scarce data is available for the selenium status of the Bulgarian population especially for patients with thyroid disorders. Aim: To compare the serum selenium (s-Se) concentrations in patients with ATD and healthy controls from Bulgarian population. Materials and methods: The s-Se concentrations were measured in 105 patients newly diagnosed or untreated for the previous 6 months with ATD (mean age 44±13 years). The patients were divided into three groups: euthyroid autoimmune thyroiditis (AIT) (n=31), hypothyroid AIT (n=33), and hyperthyroid patients with AIT or Graves’ disease (GD) (n=41). The results were compared to s-Se concentrations in 40 age- and sex-matched healthy controls. Determination of s-Se was carried out by inductively coupled plasma mass spectrometry (ICP-MS) after microwave-assisted acid mineralization of the serum samples. Results: The s-Se concentrations in patients with hyperthyroidism were significantly lower than those in the control group (hyperthyroidism: 69±15.0 µg/L vs. controls: 84±13 µg/L, p<0.001). There was no significant difference in the s-Se concentrations between euthyroid and hypothyroid participants with AIT and healthy controls. The s-Se concentrations in our control individuals were within the range of 53-137 µg/L, reported in literature data on mean serum and plasma levels of European healthy adults. Conclusions: The mean s-Se concentrations observed in all groups were below or close to the cutoff value of 80 µg/L, considered optimal for the activity of the Se-dependent antioxidant systems.

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Section: Discussionmentioning

confidence: 99%