Selenium Determination in Biological Fluids Using Zeeman Background Correction Electrothermal Atomic Absorption Spectrometry

Campillo, Natalia; Viñas, Pilar; López-Garcı́a, Ignacio; Hernández‐Córdoba, Manuel

doi:10.1006/abio.2000.4516

Cited by 31 publications

(15 citation statements)

References 13 publications

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“…Selenium concentrations in serum and tissues were measured by electrothermal atomic absorption spectrometry as previously described (Campillo et al, 2000). No preliminary step is required for the measurement of selenium concentrations in serum, whereas an atomization step followed by drying is required to measure selenium concentrations in tissues.…”

Section: Selenium Measurementmentioning

confidence: 99%

Role of selenium in heart lesions produced by neuroleptics in the rabbit

Vaillant

Turrel

Bost

et al. 2007

J of Applied Toxicology

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Organic and/or functional heart lesions sometimes resulting in sudden death have been described in psychiatric patients treated with neuroleptics. As selenium has been suggested previously to play a role in the development of such lesions, the present study was undertaken to determine whether a correlation could be found between heart lesions induced by neuroleptics and changes in blood selenium as well as myocardial tissue concentrations in the rabbit. Twelve NZW adult rabbits were treated intramuscularly with both levomepromazine (3 mg kg(-1) day(-1)) and risperidone (1 mg kg(-1) once every other week) for 3 months, and compared with 12 saline-treated controls. Blood samples were drawn before and at the end of the study. Tissue samples from the heart, liver and kidneys were obtained at the end of treatment, and the hearts were examined histologically. Heart lesions including disorganization of cardiac fibers, myolysis, interstitial and endocardial fibrosis, and necrosis were noted in treated animals, but not in controls. There was a 20% decrease in selenium blood levels and a 50% decrease in selenium myocardial tissue levels in treated animals compared with controls (P < 0.001). In contrast, no differences in selenium levels in liver and kidneys were found across the experimental groups. These results suggest a possible correlation between selenium depletion and neuroleptics-induced heart lesions.

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Section: Selenium Measurementmentioning

confidence: 99%

Role of selenium in heart lesions produced by neuroleptics in the rabbit

Vaillant

Turrel

Bost

et al. 2007

J of Applied Toxicology

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“…25 Typical between-batch precision (coe⁄cients of variation [CVs]) for these assays were 3.9%, 2.27% and 3.65%, respectively.…”

Section: Serum Trace Element Analysismentioning

confidence: 99%

Determinants of serum copper, zinc and selenium in healthy subjects

et al. 2005

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“…We included alcoholics with [12] and without [13] HCV infection, as well as nine nonalcoholic HCV-infected patients, and a control group [14], whose clinical and biochemical characteristics are detailed in Table 1. Patients were admitted to our hospital via the emergency room because of infection (16 cases), major withdrawal symptoms (22 cases), decompensation of alcoholic liver disease (28 cases), or programmed liver biopsy (21 cases).…”

Section: Patients and Controlsmentioning

confidence: 99%

“…Serum copper, zinc, and selenium were determined using a Spectra A 220-Z atomic absorption spectrophotometer equipped with a Zeeman effect, a VARIAN GTA 110Z graphite furnace with pyrolized tubes provided with a L'vov platform, and a microcomputer-controlled AS-40 auto sampling system, following already described procedures [12]. Briefly, serum samples and lyophilized serum reference samples, supplied by Seronorm (Billingstad, Norway; Seronorm, REF 201405, LOT JL4409) were diluted with a 0.1 % w/v Triton X-100 solution (Merck p.a., Darmstadt, Germany).…”

Section: Trace Elementsmentioning

confidence: 99%

Relative and Combined Effects of Chronic Alcohol Consumption and HCV Infection on Serum Zinc, Copper, and Selenium

González‐Reimers

Martín-González

Alemán-Valls

et al. 2009

Biol Trace Elem Res

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In alcoholic hepatitis, Kupffer cells are activated by intestinal gram-bacteria, leading to cytokine production and free radicals release, which, enhancing cytokine secretion, create a positive feedback loop which contributes to liver inflammation. Free radicals also damage the liver in chronic hepatitis C virus (HCV) infection, a condition frequently associated to alcohol consumption. In both situations, activity of antioxidant enzymes and of its cofactors zinc (Zn), selenium (Se), and copper (Cu) is important. This study was performed to assess the relative and combined effects of chronic alcoholism and HCV infection on serum Se, Zn, and Cu, and its relation with serum malondialdehyde (MDA) and tumor necrosis factor-α, interferon-γ, and interleukins (IL) 4, 6, and 8, in 19 HCV- alcoholic patients, 12 HCV+ alcoholic patients, nine HCV+ non-alcoholic patients, and 20 controls. Serum Zn and Se were lower in both HCV+ and HCV- alcoholic patients, whereas serum Cu was lower in HCV+ individuals. Serum Zn and Se were related to liver function derangement. MDA levels were higher in alcoholics, but no relation was observed between trace elements and MDA or cytokines, so that our results do not support a relevant role of the analyzed trace elements in the pathogenesis of chronic liver disease.

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Selenium Determination in Biological Fluids Using Zeeman Background Correction Electrothermal Atomic Absorption Spectrometry

Cited by 31 publications

References 13 publications

Role of selenium in heart lesions produced by neuroleptics in the rabbit

Role of selenium in heart lesions produced by neuroleptics in the rabbit

Determinants of serum copper, zinc and selenium in healthy subjects

Relative and Combined Effects of Chronic Alcohol Consumption and HCV Infection on Serum Zinc, Copper, and Selenium

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