Selenium intake and metabolic syndrome: A systematic review

Retondario, Anabelle; Fernandes, Ricardo; Rockenbach, Gabriele; Alves, Mariane de Almeida; Bricarello, Liliana Paula; Trindade, Erasmo Benício Santos de Moraes; Vasconcelos, Francisco de Assis Guedes de

doi:10.1016/j.clnu.2018.02.021

Cited by 26 publications

(14 citation statements)

References 88 publications

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“…Selenium deficiency is harmful to health and even leads to certain illnesses. A direct association between Se intake and metabolic syndrome has recently been found …”

Section: Introductionmentioning

confidence: 94%

Selenium affects the activity of black tea in preventing metabolic syndrome in high‐fat diet‐fed Sprague–Dawley rats

Gao

Ruan

et al. 2019

J Sci Food Agric

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BACKGROUND: Metabolic syndrome, a group of factors that increase the risk of health problems, is becoming increasingly common. Strategies to prevent metabolic syndrome have received substantial attention. Black tea consumption and selenium (Se) intake have been reported to be associated negatively with the prevalence of metabolic syndrome. We therefore sought to investigate whether Se-rich black tea might have a stronger effect than Se-deficient black tea in the prevention of metabolic syndrome.RESULTS: Sprague-Dawley rats were divided into four groups and fed a normal rodent diet, high-fat diet, high-fat diet containing 3% Se-rich black tea, or a high-fat diet containing 3% Se-deficient black tea for 4 weeks. Blood and tissue samples were tested at the end of the experiment. The results suggested that both types of black tea ameliorated high-fat diet-induced body-weight gain, lowered serum triglycerides and attenuated intestinal barrier dysfunction. Selenium-rich black tea showed stronger activity in decreasing fasting serum glucose and increasing insulin sensitivity, as well as stronger hepatoprotection, owing to higher total antioxidant capacity and activated hepatic antioxidant enzymes. However, it did not exhibit better effects in preventing fat accumulation. The different effects of Se-rich and Se-deficient black tea on the gut microbiota might have been partially responsible for the results. CONCLUSION: Compared with Se-deficient black tea, Se-rich black tea displayed stronger activity in preventing high-fat diet-induced hyperglycemia and liver damage but was not better at preventing fat accumulation and attenuating dysbiosis. More experiments are needed to understand the underlying mechanisms further. Effects on intestinal barrier functionPrevious studies have implicated a causal relationship between the pathophysiological changes in the gut epithelium and altered gut J Sci Food Agric 2020; 100: 225-234

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“…Selenium deficiency is harmful to health and even leads to certain illnesses. A direct association between Se intake and metabolic syndrome has recently been found …”

Section: Introductionmentioning

confidence: 94%

Selenium affects the activity of black tea in preventing metabolic syndrome in high‐fat diet‐fed Sprague–Dawley rats

Gao

Ruan

et al. 2019

J Sci Food Agric

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“…Half of the 25 studies did not show any relationship between selenium and hypertension, whereas the other half found either a positive or a negative association [ 11 ]. Another systematic review published in 2019 identified six studies on the association between selenium intake and metabolic syndrome, and the association was found to be inconclusive [ 12 ]. These conflicting findings may be because selenium status is positively related to the different study populations’ soil selenium levels.…”

Section: Introductionmentioning

confidence: 99%

Regional Difference in the Association between the Trajectory of Selenium Intake and Hypertension: A 20-Year Cohort Study

et al. 2021

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The effect of selenium on hypertension is inconclusive. We aimed to study the relationship between selenium intake and incident hypertension. Adults (age ≥20 years) in the China Health and Nutrition Survey were followed up from 1991 to 2011 (N = 13,668). The latent class modeling method was used to identify trajectory groups of selenium intake. A total of 4039 respondents developed hypertension. The incidence of hypertension was 30.1, 30.5, 30.6, and 31.2 per 1000 person-years among participants with cumulative average selenium intake of 21.0 ± 5.1, 33.2 ± 2.8, 43.8 ± 3.6, and 68.3 ± 25.2 µg/day, respectively. Region and selenium intake interaction in relation to hypertension was significant. In the multivariable model, cumulative intake of selenium was only inversely associated with the incident hypertension in northern participants (low selenium zone), and not in southern participants. Compared to selenium intake trajectory Group 1 (stable low intake), all three trajectory groups had a low hazard ratio for hypertension among the northern participants. However, Group 4 (high intake and decreased) showed an increasing trend of hypertension risk in the south. In conclusion, the association between selenium intake and the incidence of hypertension varied according to regions in China. In the low soil selenium zone, high selenium intake might be beneficial for hypertension prevention.

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“…Yet, this “improved” Se profile has been shown to have a beneficial effect on aging and age-related manifestations [ 41 , 49 , 50 ]. Although a negative association or even no association between Se intake and metabolic syndrome has been reported [ 51 ], the risk of developing this cluster of disorders may increase in people with elevated Se levels [ 52 , 53 , 54 , 55 ]. Since high SeS values (>120 μg/L) were recorded in more than 25% of our studied population ( Figure 4 ), there is a need for meticulous monitoring of this population group in line with an adequate diet and controlled administration of Se supplements to reduce potential undesirable effects.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Selenium Status by Age and Gender: A Retrospective Observational Cohort Study in Western Romania

et al. 2021

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Selenium, residing in a series of selenoproteins, plays an important role in both female and male reproductive function. Of particular significance for reproduction is the antioxidant glutathione peroxidase (GPx), a main selenoenzyme, whose level is regulated by the availability of Se in the body. We hypothesized that changes in Se status, closely related to GPx activity, would result in an increased risk of reproductive dysfunction in individuals. We retrospectively investigated the serum selenium (SeS) concentrations of 1264 apparently healthy people, aged 16–89 years, from Western Romania. The general analysis revealed a non-normal SeS distribution with a median SeS of 100.26 ± 18.32 μg/L and a significant difference in SeS levels between age groups. The analysis of the young group (16–35 years) revealed that up to 50% of individuals did not reach the SeS threshold corresponding to maximum GPx activity (80 μg/L), and a significant imbalance between the genders was apparent when looking at SeS values outside the range. Our results correlated with the general diminished reproductive ability registered in Romania during the last few years. Serum selenium content proves to offer a proper reflection of the fertility competence of the young population, and its monitoring is important for guiding dietary adjustments and attaining normal reproductive function.

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Selenium intake and metabolic syndrome: A systematic review

Cited by 26 publications

References 88 publications

Selenium affects the activity of black tea in preventing metabolic syndrome in high‐fat diet‐fed Sprague–Dawley rats

Selenium affects the activity of black tea in preventing metabolic syndrome in high‐fat diet‐fed Sprague–Dawley rats

Regional Difference in the Association between the Trajectory of Selenium Intake and Hypertension: A 20-Year Cohort Study

Evaluation of Serum Selenium Status by Age and Gender: A Retrospective Observational Cohort Study in Western Romania

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