Selenium: its role as antioxidant in human health

Tinggi, Ujang

doi:10.1007/s12199-007-0019-4

Cited by 485 publications

(297 citation statements)

References 81 publications

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“…It also prevents LPO and works as a component of SOD [101,102]. Selenium is also an essential component of the glutathione peroxidase selenoproteins [103]. Several studies reported that the mixed antioxidants including zinc and selenium could decrease sperm DNA fragmentation and increase clinical pregnancy rates [104].…”

Section: Oral Antioxidant Therapymentioning

confidence: 99%

Reactive Oxygen Species and Sperm Cells

Takeshima¹,

Kuroda²,

Yumura³

2018

Reactive Oxygen Species (ROS) in Living Cells

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Many cases of male factor infertility are idiopathic, but 30-40% of cases may have excessive levels of reactive oxygen species (ROS) in their semen. The origins of endogenous ROS are leukocytes and immature spermatozoa, and external causes are various. On the contrary, seminal plasma contains various antioxidants. Low levels of ROS are essential for the fertilization process, but excessive levels of ROS lead to oxidative stress and can have harmful effects such as lipid peroxidation of a membrane, sperm deoxyribonucleic acid fragmentation, and apoptosis on the fertile capacity. In order to evaluate oxidative stress appropriately, ROS is measured by the chemiluminescence method with neat semen and quantification of 8-OH-2′-deoxyguanosine and malondialdehyde in seminal plasma. Antioxidant potential is often measured using total antioxidant capacity (TAC) assay. The oxidation-reduction potential measured by a MiOXSYS analyzer is a novel, easier, quicker, and less expensive technology to measure oxidative stress. In order to minimize oxidative stress and improve clinical outcomes, sperm-sorting methods, lifestyle modifications, shortening the ejaculatory abstinence, and treatments such as oral antioxidants, varicocelectomy, and testicular sperm extraction are taken into account. As a future prospect, proteomics, metabolomics, and genomics are still developing areas that have the potential to discover new findings and highly sensitive biomarkers.

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Section: Oral Antioxidant Therapymentioning

confidence: 99%

Reactive Oxygen Species and Sperm Cells

Takeshima¹,

Kuroda²,

Yumura³

2018

Reactive Oxygen Species (ROS) in Living Cells

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“…The level of Se generally depends on its level in soil. 84 Selenium is a mineral, not an antioxidant nutrient. However, it is a component of antioxidant enzymes.…”

Section: -83mentioning

confidence: 99%

Antioxidants: An Overview on the Natural and Synthetic Types

Atta¹,

Mohamed²,

Abdelgawad³

2017

ECB

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“…Se is a component of antioxidant enzymes via amino acid (selenocysteine, selenomethionine) and proteins [21][22][23]. Zn is a component of enzymes participating in the synthesis and degradation of different biomolecules including lipids, proteins, carbohydrates and nucleic acids as well as in the metabolism of other micronutrients [19].…”

Section: Introductionmentioning

confidence: 99%