Selenium nanoparticles are more efficient than sodium selenite in reducing the toxicity of aflatoxin B₁ in Japanese quail

Abstract

Background: Dietary selenium (Se), as an antioxidant element, plays a protective role in aflatoxin B 1 (AFB 1 ) toxicosis in poultry.Objectives: To compare the effects of sodium selenite (SS) and Se nanoparticles (SeNPs) against AFB 1 -induced toxicity on growth performance, carcass traits, immune response, antioxidant status and serum lipid concentrations in Japanese broiler quails.Methods: A total of 540 quails were divided into six treatments, each with six replicates and 15 birds per replicate at 24 days of age and reared for 21 days. Treatments included: (1) a basal diet without Se and AFB 1 (negative control; NC); (2) NC + 1.0 mg/kg AFB 1 (positive control; PC); (3) PC + 0.2 mg/kg Se as SS; (4) PC + 0.5 mg/kg Se as SS; (5) PC + 0.2 mg/kg Se as SeNPs; and (6) PC + 0.5 mg/kg Se as SeNPs.Results: Treatment with PC diet decreased feed intake and body weight gain and increased feed conversion ratio than the NC diet. The PC diet also atrophied the lymphoid organs and depressed antibody responses against Newcastle disease and avian influenza viruses and sheep red blood cell. Moreover, quails treated with PC diet appeared to have lower serum glutathione peroxidase and thioredoxin reductase activities and disturbed serum lipids than those receiving the NC diet. Dietary Se attenuated these detrimental effects, but failed to completely eliminate them. Additionally, SeNPs performed better than SS in improving thioredoxin reductase activity and antibody titer against sheep red blood cell.Conclusions: Diet supplementation with SeNPs to provide 0.5 mg/kg of Se is recommended to reduce the AFB 1 toxicosis in broiler quails.

Soybean Oil and Selenium Yeast Supplementation in Quail's Diet: Productive Performance, Fatty Acid Profile, Enzyme Activity, and Oxidative Stability of Meat

“…[17] There are many studies in the literature which have tested Se addition in quails' diets to improve the oxidative stability of the meat, however the antioxidant role of Se is still unclear [12,15] and the effects of organic or inorganic Se as dietary supplementation on its final concentration in quail meat and on the meat quality are not conclusive. [16,18] In fact, the role of SeY supplementation in quails' diets has not yet been elucidated in the literature, and more specifically there are no studies on the possible synergistic action between soybean oil (SO) and SeY on lipids, fatty acids, and the oxidative stability of meat.…”

Nano‐selenium relieved hepatic and renal oxidative damage in hypothyroid rats

“…In addition, Se performs a basic role in lipid metabolism, and Se defect can disturb the plasma lipid profile (Xu et al, 2017). Along with this evidence, the results of some studies show that Se supplementations improved the detrimental effects of toxins on the immune system and antioxidant defense (Khazraei et al, 2021). Therefore, the use of selenium nanoparticles (SeNPs) is preferred to Se (Talebi et al, 2017).…”