Selenium Nanoparticles Dispersed in Phytochemical Exert Anti-Inflammatory Activity by Modulating Catalase, GPx1, and COX-2 Gene Expression in a Rheumatoid Arthritis Rat Model

Ren, Shi-Xiang; Zhan, Bin; Lin, Yuan; Ma, Desi; Yan, Hui

doi:10.12659/msm.912545

Cited by 39 publications

(41 citation statements)

References 52 publications

(60 reference statements)

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“…We [25] also observed that SeNPs treated animals shows reduced anti-in ammatory molecules like, TNFα, IL-6 etc., To get insight in the mechanism of action of SeNPs in RA condition, in the present study we have analyzed the effect of SeNPs on activated neutrophils with reference to NETs. Freund's complete and incomplete adjuvants, p-coumaric acid, (CA) and Cell Death Detection ELISAPLUS (Version 14, Roche Diagnostics) were obtained from Sigma chemicals.…”

Section: Introductionsupporting

confidence: 56%

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Neutrophil Extracellular Traps Induced in Rheumatoid Arthritis Conditioned Animals are Inhibited Through Selenium Nanoparticles Supplementation

Zhang¹,

Zhao²,

Lin³

et al. 2020

Preprint

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Growing experimental evidence shows that the neutrophil extracellular traps (NETs) plays vital contribution in rheumatoid arthritis (RA). Selenium (Se) and Se nanoparticles (SeNPs) known to modulate RA-induced pathogenesis through antioxidant gene modulation. In the present study we have inferred that SeNPs supplementation effectively controls NETs formation, which in turn could curtail RA-induced inflammatory response.Neutrophils obtained from different experimental conditions were used to evaluate the in vitro NETs formation and inhibition of through SeNPs supplementation. Increased oxidative stress, decreased antioxidant enzyme activities and increased inflammatory cytokines were observed in neutrophils of RA, whereas SeNPs treatment attenuate it. Neutrophils obtained from control and SeNPs supplemented groups do not have statistically significant Se level between the groups, on the other hand reduced the oxidative stress. Neutrophils of RA forms more spontaneous NETs in vitro culture than that of control and SeNPs treated neutrophils. Neutrophils obtained from RA rats are more inclined for external NETs inducing agent such as lipopolysaccharides and phorbol 12-myristate 13-acetate, when compared with SeNPs treated and control neutrophils. On the other hand in vitro pre-treatment of neutrophils with SeNPs before exposing to NETs inducing substances, indicate the anti-NETs forming property of SeNPs. This effect could be mediated through reduction in major inflammatory mediators namely TNF-α, IL-17 and IL-6. This findings confirms that SeNPs could act as effective NETs formation blocking agent. Our present and previous observation conclude that SeNPs, could serve as an effective anti-arthritic agent warranting human study. Furthermore, this study also throws light on the new information such as SeNPs which could be used as therapeutics agent, where NETs is major pathogenic factor.

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Section: Introductionsupporting

confidence: 56%

“…Se concentration is found to be low in serum of RA patients, indicating the essential role of Se in RA patients management [24]. Recently we observed that SeNPs dispersed in bio-active compound have excellent anti-arthritic activity in animal model [25].…”

Section: Introductionmentioning

confidence: 98%

Neutrophil Extracellular Traps Induced in Rheumatoid Arthritis Conditioned Animals are Inhibited Through Selenium Nanoparticles Supplementation

Zhang¹,

Zhao²,

Lin³

et al. 2020

Preprint

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“…In some cases, animals treated with SeNPs showed significant restoration of these enzyme levels compared to those treated with prednisolone (10 mg/kg/day) [ 63 ]. Three years later, this result was replicated by another research group, where an increase in the expression of antioxidant enzymes was also shown (GPx1 and catalase) [ 64 ]. In another study, the design of polypeptide composite SeNPs (0.5 mg/kg −1 , ‘Se@RuNPs’) showed anti-inflammatory effects.…”

Section: Nutritional Selenium Status In Rheumatoid Arthritismentioning

confidence: 67%

“…Recently, some preclinical studies with Se nanoparticles (SeNPs) have been carried out with the aim of proposing complementary therapies in RA. These studies have been conducted on the basis that the dosage and chemical form of Se is important, since it has been shown that high doses of Se compounds (organic and inorganic) or Se enriched yeast can cause toxicity [ 63 , 64 , 65 ]. Furthermore, it has previously been shown that ROS production is involved in RA pathogenesis by inducing an oxidative state that activates the inflammatory processes of the joints causing tissue damage in RA patients [ 66 ].…”

Section: Nutritional Selenium Status In Rheumatoid Arthritismentioning

confidence: 99%

The Relevance of Selenium Status in Rheumatoid Arthritis

Turrubiates-Hernández

Márquez‐Sandoval

González-Estévez

et al. 2020

Nutrients

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Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that can cause joint damage. Among the environmental risk factors, diet plays an important role because it can aggravate or attenuate inflammation. Selenium (Se) is considered an essential trace element since it is a structural component of antioxidant enzymes; however, its concentration can be affected by diet, drugs and genetic polymorphisms. Studies have reported that RA patients have a deficient diet in some food groups that is associated with parameters of disease activity. Furthermore, it has been shown that there is an alteration in serum Se levels in this population. Although some clinical trials have been conducted in the past to analyze the effect of Se supplementation in RA, no significant results were obtained. Contrastingly, experimental studies that have evaluated the effect of novel Se nanoparticles in RA-induced models have shown promising results on the restoration of antioxidant enzyme levels. In particular, glutathione peroxidase (GPx) is an important selenoprotein that could have a modulating effect on inflammation in RA. Considering that RA patients present an inflammatory and oxidative state, the aim of this review is to give an overview of the current knowledge about the relevance of Se status in RA.

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“…The expression level of inflammatory cytokines (COX‐2, TNF‐α, IL‐1β, IL‐6, and MCP‐1) reverted back to near normal levels after supplying 500 µg kg −1 body weight (b.w.) SeNPs 107…”

Section: Nanotherapeutics Of Ra Based On Nanodrugsmentioning

confidence: 99%

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

Wang

Meng

et al. 2020

Adv Healthcare Materials

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Early diagnosis, standardized treatment, and regular monitoring are the clinical treatment principle of rheumatoid arthritis (RA). The overarching principles and recommendations of treat‐to‐target (T2T) in RA advocate remission as the optimum aim, especially for patients with very early disease who are initiating therapy with anti‐RA medications. However, traditional anti‐RA drugs cannot selectively target the inflammatory areas and may cause serious side effects due to its short biological half‐life and poor bioavailability. These limitations have significantly driven the research and application of nanomaterial‐based drugs in theranostics of RA. Nanomedicines have appropriate sizes and easily modified surfaces which can enhance their biological compatibility and prolong circulation time of drug‐loading systems in vivo. Traditional T2T regimens cannot evaluate the efficacy of drugs in real time, while clinical drug nanosizing can realize the integration of diagnosis and treatment of RA. This review bridges clinically proposed T2T concepts and nanomedicine in an integrated system for RA early‐stage diagnosis and treatment. The most advanced progress in various nanodrug delivery systems for theranostics of RA is summarized, establishing a clear path and a new perspective for further optimization of T2T. Finally, the key facing challenges are discussed and prospects are addressed.

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Selenium Nanoparticles Dispersed in Phytochemical Exert Anti-Inflammatory Activity by Modulating Catalase, GPx1, and COX-2 Gene Expression in a Rheumatoid Arthritis Rat Model

Cited by 39 publications

References 52 publications

Neutrophil Extracellular Traps Induced in Rheumatoid Arthritis Conditioned Animals are Inhibited Through Selenium Nanoparticles Supplementation

Neutrophil Extracellular Traps Induced in Rheumatoid Arthritis Conditioned Animals are Inhibited Through Selenium Nanoparticles Supplementation

The Relevance of Selenium Status in Rheumatoid Arthritis

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

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