Selenium nanoparticles prevents lead acetate-induced hypothyroidism and oxidative damage of thyroid tissues in male rats through modulation of selenoenzymes and suppression of miR-224

Atteia, Hebatallah Husseini; Arafa, Manar Hamed; Prabahar, Kousalya

doi:10.1016/j.biopha.2018.01.083

Cited by 28 publications

(11 citation statements)

References 46 publications

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“…In another study, nanoselenium was found to be less toxic than SeMet in inducing liver toxicity in mice [148], although both nanosized Se and SeMet increased the liver and kidney GPx and TrxR activity with similar efficacy [148]. There are reports on the protective effects of nanoselenium against various toxic elements such as lead [149] and chromium (VI) [150] as well as the ameliorative action of nanoselenium against As III already mentioned in earlier chapters [99]. Altogether, nanoselenium appears as a very attractive form of Se for the treatment of As III or Cd intoxication, but more studies on this topic are needed.…”

Section: Discussionmentioning

confidence: 99%

The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature

Zwolak

2019

Biol Trace Elem Res

242

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Arsenic (As) and cadmium (Cd) are elements arousing major public health concerns associated with environmental pollution, high toxicity potential, and carcinogenic nature. However, selenium (Se) at low doses and incorporated into enzymes and proteins has antioxidant properties and protects animals and humans from the risk of various diseases. It also has an exceptionally narrow range between necessary and toxic concentrations, which is a well-known hindrance in its use as a dietary supplement. The present article aims to update and expand the role of Se in As and Cd toxicity discussed in our earlier paper. In general, recent reports show that Se, regardless of its form (as selenite, selenomethionine, nanoSe, or Se from lentils), can reduce As- or Cd-mediated toxicity in the liver, kidney, spleen, brain, or heart in animal models and in cell culture studies. As was suggested in our earlier review, Se antagonizes the toxicity of As and Cd mainly through sequestration of these elements into biologically inert complexes and/or through the action of Se-dependent antioxidant enzymes. An increase in the As methylation efficiency is proposed as a possible mechanism by which Se can reduce As toxicity. However, new studies indicate that Se may also diminish As or Cd toxicity by activation of the Nrf2 pathway. In addition, this paper discusses possible signs of Se toxic effects, which may be a challenge for its future use in the therapy of As and Cd poisoning and provide future directions to address this issue.

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Section: Discussionmentioning

confidence: 99%

The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature

Zwolak

2019

Biol Trace Elem Res

242

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“…For example, co-administration of nano-Se high dose along with di- n -butyl phthalate significantly decreased the level of MDA, and also improved GSH concentration and GPx and SOD activities initially compromised by the toxicant treatment (Rashad et al ., 2018). Similarly, in male rats treated with lead acetate, oxidative stress was observed in thyroid tissues and nano-Se supplementation restored antioxidant defence mechanisms (GPx, catalase (CAT), SOD, and GSH) and expression of iodothyronine deiodinase type 1 which were compromised due to the lead-acetate treatment (Atteia et al ., 2018). Protective effects of nano-Se against oxidative stress and testicular damage induced by free-radical producing chemical bisphenol A (BPA) was also shown (Abdel-Halim et al ., 2016).…”

Section: Discussionmentioning

confidence: 99%

Food for thought: nano-selenium in poultry nutrition and health

Surai

Kochish

2020

Anim. Health. Res. Rev.

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In recent years, nanoparticles have become a fashionable subject of research due to their sizes, shapes, and unique intrinsic physicochemical properties. In particular for the last 5 years, nano-Se has received tremendous attention in terms of its production, characteristic, and possible application for poultry/animal science and medical sciences. Indeed, Nano-Se is shown to be a potential source of Se for poultry/animal nutrition. However, there is an urgent need to address the questions related to nano-Se absorption, assimilation, and metabolism. It is not clear at present if major biological effects of nano-Se are due to Se-protein synthesis, direct antioxidant/prooxidant effects, or both. It is necessary to understand how metallic nano-Se can be converted into H2Se and further to SeCys to be incorporated into selenoproteins. The aforementioned issues must be resolved before nano-Se finds its way to animal/poultry production as a feed supplement and clearly this subject warrants further investigation.

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“…In the experiments of proving the effect of Nano-Se on hyperhomocysteinemic rats, SD rats or SHRs or Wistar rats were randomly divided into a Hcy group and a Hcy+Nano-Se group with 6 rats per group, respectively. The protocol of the study, including doses and duration of treatment for Nano-Se, were all designed according to our pilot studies and previous reports, [18][19][20] which have demonstrated its protective effects. Chronic hyperhomocysteinemia was induced as described previously, 21,22 with a minor modification.…”

Section: Animals and Treatmentmentioning

confidence: 99%

<p>Anti-Oxidant and Anti-Endothelial Dysfunctional Properties of Nano-Selenium in vitro and in vivo of Hyperhomocysteinemic Rats</p>

Zheng¹,

Liu²,

Zhou³

et al. 2020

IJN

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Elevation of blood homocysteine (Hcy) level (hyperhomocysteinemia) is a risk factor for cardiovascular disorders and is closely associated with endothelial dysfunction. The present study aims to investigate the protective effect and underlying mechanism of nanoscale selenium (Nano-Se) in Hcy-mediated vascular endothelial cell dysfunction in vitro and in vivo. Materials and Methods: By incubating vascular endothelial cells with exogenous Hcy and generating hyperhomocysteinemic rat model, the effects of Nano-Se on hyperhomocysteinemia-mediated endothelial dysfunction and its essential mechanisms were investigated. Results: Nano-Se inhibited Hcy-induced mitochondrial oxidative damage and apoptosis by preventing the downregulation of glutathione peroxidase enzyme 1 and 4 (GPX1, GPX4) in the vascular endothelial cells, thus effectively prevented the vascular damage in vitro and in vivo in the hyperhomocysteinemic rats. Nano-Se possessed similar protective effects but lower toxicity against Hcy in vascular endothelial cells when compared with other forms of Se. Conclusion: The application of Nano-Se could serve as a novel promising strategy against Hcy-mediated vascular dysfunction with reduced risk of Se toxicity.

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Selenium nanoparticles prevents lead acetate-induced hypothyroidism and oxidative damage of thyroid tissues in male rats through modulation of selenoenzymes and suppression of miR-224

Cited by 28 publications

References 46 publications

The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature

The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature

Food for thought: nano-selenium in poultry nutrition and health

<p>Anti-Oxidant and Anti-Endothelial Dysfunctional Properties of Nano-Selenium in vitro and in vivo of Hyperhomocysteinemic Rats</p>

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