Selenium Nutritional Status and Glutathione Peroxidase Activity and Its Relationship with Hemodialysis Time in Individuals Living in a Brazilian Region with Selenium-Rich Soil

Barroso, Christielle Félix; Pires, Liliane Viana; Santos, Larissa Bezerra; Henriques, Gilberto Simeone; Pessoa, Priscila Pereira; Araújo, Gueyhsa Nobre de; Araújo, Camilla Oliveira Duarte de; Oliveira, Cláudia Maria Costa de; Maia, Carla Soraya Costa

doi:10.1007/s12011-020-02388-1

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…Low antioxidant levels in HD patients may also occur from limited vegetable and fruit intakes preventing hyperkalemia [93]. Resultant low intakes of vitamin A, C, and E and selenium would affect antioxidant defense mechanisms [93,94]. Additionally, involuntary removal of vitamins also occurs with every HD session as mentioned in Section 3.1.…”

Section: Dialysis-induced Inflammationmentioning

confidence: 99%

Understanding Development of Malnutrition in Hemodialysis Patients: A Narrative Review

et al. 2020

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Hemodialysis (HD) majorly represents the global treatment option for patients with chronic kidney disease stage 5, and, despite advances in dialysis technology, these patients face a high risk of morbidity and mortality from malnutrition. We aimed to provide a novel view that malnutrition susceptibility in the global HD community is either or both of iatrogenic and of non-iatrogenic origins. This categorization of malnutrition origin clearly describes the role of each factor in contributing to malnutrition. Low dialysis adequacy resulting in uremia and metabolic acidosis and dialysis membranes and techniques, which incur greater amino-acid losses, are identified modifiable iatrogenic factors of malnutrition. Dietary inadequacy as per suboptimal energy and protein intakes due to poor appetite status, low diet quality, high diet monotony index, and/or psychosocial and financial barriers are modifiable non-iatrogenic factors implicated in malnutrition in these patients. These factors should be included in a comprehensive nutritional assessment for malnutrition risk. Leveraging the point of origin of malnutrition in dialysis patients is crucial for healthcare practitioners to enable personalized patient care, as well as determine country-specific malnutrition treatment strategies.

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Section: Dialysis-induced Inflammationmentioning

confidence: 99%

Understanding Development of Malnutrition in Hemodialysis Patients: A Narrative Review

et al. 2020

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“…It found that the patients who had undergone hemodialysis for 60 months or more had lower GPX activity than those who had undergone the treatment for less than 60 months. 20 Though, these findings were not significant after adjusting with age and gender .This could be explained by the significant role played by the GPX in the reduction of lipid and hydrogen peroxides. If GPX activity is decreased, more hydrogen peroxide is found, which leads to direct tissue injury and establishment of inflammatory pathways.…”

Section: We Found That There Was No Relation Between Gpx and Duration...mentioning

confidence: 85%

Relation between Hemodialysis and Oxidative Stress Markers’ blood levels in End Stage Renal Disease on Regular Dialysis

Hossam Arafat,

Safwat Elaraby,

Wahid Elsaid

et al. 2023

The Egyptian Journal of Geriatrics and Gerontology

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Background: Chronic kidney disease (CKD) is a common medical problem in elderly. The progressive worsening of renal function in CKD induces numerous biological and clinical dysfunctions including augmentation of synthesis of inflammation and oxidative stress mediators. Aim of the Work:The aim was to study relation between frequency of hemodialysis and oxidative stress markers' blood levels in end stage renal disease (ESRD) patients on regular dialysis. Patients and Methods: This is a cross-sectional study that was done on a convenience sample of 80 cases of elderly patients,60years and older, who had ESRD and on regular dialysis. The study was conducted in the hemodialysis unit at Ain Shams University Hospital (El-Demerdash).The study period was from the first of May 2021to the end ofNovember2021. Results: We found a statistically significant positive correlation between hemodialysis related factors, namely duration of hemodialysis, number of sessions, and duration of each session and the blood levels of oxidative stress markers. Conclusion:Patients with ESRD on regular hemodialysis are at increased risk of oxidative stress risks as they are shown to have higher oxidative stress biological markers which are directly related to duration of being on hemodialysis, number of hemodialysis sessions and the duration of each session.

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“…Similar results were obtained by Wang et al [ 21 ]. It has been revealed in the literature that the duration of dialysis in MHD patients is associated with increased oxidative stress as well as decreased serum antioxidant enzymes [ 23 ], oxidative stress is prevalent in chronic kidney disease and may heighten the risk of cardiovascular disease, cachexia, anemia, and other comorbid conditions, oxidative stress is an imbalance between pro-oxidant production and antioxidant defense mechanisms. Besides, the pro-oxidant and antioxidant activities of patients in distinct stages of chronic kidney disease are divergent, while hemodialysis patients have the most impaired renal function.…”

Section: Discussionmentioning

confidence: 99%

Cerebral blood flow changes in maintenance hemodialysis patients with restless legs syndrome and their clinical significance:a cross-sectional case-control study

Li,

Sun,

et al. 2024

BMC Neurol

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Objective Restless legs syndrome (RLS) stands as a prevalent neurological complication within maintenance hemodialysis (MHD) patients. However, the alterations in cerebral blood flow (CBF) among MHD-RLS patients remain uncharted. Through the utilization of the arterial spin labeling (ASL) technique, we evaluated the fluctuations in CBF within distinct brain regions and analyzed the risk factors for the development of RLS in MHD patients in the context of the clinic. Methods Thirty-one MHD patients with concomitant RLS (MHD-RLS group) and thirty-one non-RLS patients matched based on age, gender, as well as cognitive function (MHD-nRLS group) were included. Through image preprocessing and data analysis, the changes in CBF values in distinct brain regions were obtained, and the CBF values of brain regions with substantial differences between the two groups were correlated with the RLS scores. Furthermore, the differences in baseline data were compared, and through the utilization of multifactorial logistic regression, the independent risk factors for the development of RLS were examined. Results Compared with the MHD-nRLS group, the MHD-RLS group had increased CBF in the right superior temporal gyrus, reduced CBF in the right hippocampus, left middle frontal gyrus, inferior frontal gyrus of right triangle, middle frontal gyrus of left orbit, left precentral gyrus, and left precuneus. Only left precentral gyrus CBF were negatively correlated with RLS scores after correction for dialysis duration(r = -0.436, P = 0.016). Accordingly, multifactorial regression analysis by stepwise method yielded that the left precentral gyrus CBF values(OR: 0.968, 95%CI: 0.944–0.993, P = 0.012) remained an independent risk factor for RLS in MHD patients. In addition, the results showed that hemodialysis duration (OR: 1.055, 95%CI: 1.014–1.098, P = 0.008) and serum iron levels (OR: 0.685, 95%CI: 0.551–0.852, P = 0.001) were also risk factors for the development of RLS. Conclusion Patients afflicted with MHD-RLS exhibit alterations in CBF across several brain regions. Notably, the left precentral gyrus might serve as a pivotal region influencing the onset of RLS among MHD patients. Furthermore, extended hemodialysis duration and a relative insufficiency in serum iron levels independently contribute as risk factors for RLS development within the MHD patient population.

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Selenium Nutritional Status and Glutathione Peroxidase Activity and Its Relationship with Hemodialysis Time in Individuals Living in a Brazilian Region with Selenium-Rich Soil

Cited by 6 publications

References 35 publications

Understanding Development of Malnutrition in Hemodialysis Patients: A Narrative Review

Understanding Development of Malnutrition in Hemodialysis Patients: A Narrative Review

Relation between Hemodialysis and Oxidative Stress Markers’ blood levels in End Stage Renal Disease on Regular Dialysis

Cerebral blood flow changes in maintenance hemodialysis patients with restless legs syndrome and their clinical significance:a cross-sectional case-control study

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