Selenium status and cardiovascular diseases: meta-analysis of prospective observational studies and randomized controlled trials

Zhang, X.; Liu, C.; Guo, Jianjun; Song, Yiqing

doi:10.1038/ejcn.2015.78

Cited by 133 publications

(86 citation statements)

References 51 publications

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“…In contrast, there was a small increased risk of T2DM following supplementation with selenium, but this observation did not reach statistical significance [34]. Another meta-analysis of 16 prospective studies demonstrated a nonlinear association of CVD risk with selenium levels across a range of 30-165 μg/l and a beneficial effect of CVD within a narrow selenium range of 55-145 μg/l [35]; oral selenium supplementation with a median dose of 200 μg/day for 2 weeks to 144 months and a median dose of 100 μg/day for 6 to 114 months had no effect on CVD [35]. Furthermore, a priori meta-analysis of prospective observational studies documented a similar inverse relationship between CHD and selenium levels [36].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Selenium Supplementation on Glucose Metabolism and Lipid Profiles Among Patients with Metabolic Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2017

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This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of selenium administration on glucose metabolism and lipid profiles among patients with diseases related to metabolic syndrome (MetS). We searched the following databases up to May 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and assessed for quality of the studies according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as standardized mean difference (MDs) with 95% confidence intervals (95% CI). Five studies were included in the meta-analyses. The results showed that selenium supplementation significantly reduced insulin levels (SMD -0.42; 95% CI, -0.83 to -0.01) and increased quantitative insulin sensitivity check index (QUICKI) (SMD 0.83; 95% CI, 0.58 to 1.09). Selenium supplementation had no beneficial effects on other glucose homeostasis parameters, such as fasting plasma glucose (FPG) (SMD -0.29; 95% CI, -0.73 to 0.15), homeostasis model assessment of insulin resistance (HOMA-IR) (SMD -0.80; 95% CI, -1.58 to -0.03), and lipid profiles, such as triglycerides (SMD -0.42; 95% CI, -0.83 to -0.01), VLDL- (SMD -0.42; 95% CI, -0.83 to -0.01), total- (SMD -0.42; 95% CI, -0.83 to -0.01), LDL- (SMD 0.02; 95% CI, -0.20 to 0.24), and HDL-cholesterol (SMD 0.16; 95% CI, -0.06 to -0.38). Overall, this meta-analysis showed that selenium administration may lead to an improvement in insulin and QUICKI, but did not affect FPG, HOMA-IR, and lipid profiles.

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Section: Discussionmentioning

confidence: 99%

The Effects of Selenium Supplementation on Glucose Metabolism and Lipid Profiles Among Patients with Metabolic Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2017

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“…As ubiquitous components of the natural environment as well as of pollutants, multiple metals coexist in the ecosystem and reach the public through ambient air, drinking water, food, medications, and consumer products ( Nordberg et al 2014 ; Saper et al 2008 ). Several prospective studies have evaluated associations between cardiovascular outcomes and exposures to single metals, such as arsenic ( Argos et al 2010 ; Moon et al 2013 ; Wu et al 2015 ), lead ( Menke et al 2006 ; Weisskopf et al 2009 ), and selenium ( Rayman 2012 ; Zhang et al 2016 ). In a prospective case–control study nested in the Health Effects of Arsenic Longitudinal Study (HEALS) cohort of Bangladeshi adults exposed to high levels of arsenic via drinking water, researchers found positive associations between well-water arsenic and fatal and nonfatal CVD ( Wu et al 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort

Yuan

Xiao

Feng

et al. 2017

Environ Health Perspect

151

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Background:Circulating metals from both the natural environment and pollution have been linked to cardiovascular disease. However, few prospective studies have investigated the associations between exposure to multiple metals and incident coronary heart disease (CHD).Objectives:We conducted a nested case–control study in the prospective Dongfeng-Tongji cohort, to investigate the prospective association between plasma metal concentrations and incident CHD.Methods:A total of 1,621 incident CHD cases and 1,621 controls free of major cardiovascular disease at baseline and follow-up visits were matched on age (±5 years) and sex. We measured baseline fasting plasma concentrations of 23 metals and used conditional logistic regression models to estimate odds ratios (ORs) of CHD for metal concentrations categorized according to quartiles in controls.Results:Five metals (titanium, arsenic, selenium, aluminum, and barium) were significantly associated with CHD based on trend tests from single-metal multivariable models adjusted for established cardiovascular risk factors. When all five were included in the same model, adjusted ORs for barium and aluminum were close to the null, whereas associations with titanium, arsenic, and selenium were similar to estimates from single-metal models, and ORs comparing extreme quartiles were 1.32 (95% CI: 1.03, 1.69; p-trend=0.04), 1.78 (95% CI: 1.29, 2.46; p-trend=0.001), and 0.67 (95% CI: 0.52, 0.85; p-trend=0.001), respectively.Conclusions:Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. https://doi.org/10.1289/EHP1521

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“…The next-generation selenium supplements, due to reduced toxicity and controlled release, should present a lower risk of supplementation on subjects with (near) Se optimal status. Data were obtained from References [ 5 , 23 , 43 , 44 , 45 , 46 , 47 ].…”

Section: Figurementioning

confidence: 99%

Selenium Analysis and Speciation in Dietary Supplements Based on Next-Generation Selenium Ingredients

Constantinescu-Aruxandei

Frîncu

Capră

et al. 2018

Nutrients

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Selenium is essential for humans and the deficit of Se requires supplementation. In addition to traditional forms such as Se salts, amino acids, or selenium-enriched yeast supplements, next-generation selenium supplements, with lower risk for excess supplementation, are emerging. These are based on selenium forms with lower toxicity, higher bioavailability, and controlled release, such as zerovalent selenium nanoparticles (SeNPs) and selenized polysaccharides (SPs). This article aims to focus on the existing analytical systems for the next-generation Se dietary supplement, providing, at the same time, an overview of the analytical methods available for the traditional forms. The next-generation dietary supplements are evaluated in comparison with the conventional/traditional ones, as well as the analysis and speciation methods that are suitable to reveal which Se forms and species are present in a dietary supplement. Knowledge gaps and further research potential in this field are highlighted. The review indicates that the methods of analysis of next-generation selenium supplements should include a step related to chemical species separation. Such a step would allow a proper characterization of the selenium forms/species, including molecular mass/dimension, and substantiates the marketing claims related to the main advantages of these new selenium ingredients.

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Selenium status and cardiovascular diseases: meta-analysis of prospective observational studies and randomized controlled trials

Cited by 133 publications

References 51 publications

The Effects of Selenium Supplementation on Glucose Metabolism and Lipid Profiles Among Patients with Metabolic Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The Effects of Selenium Supplementation on Glucose Metabolism and Lipid Profiles Among Patients with Metabolic Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort

Selenium Analysis and Speciation in Dietary Supplements Based on Next-Generation Selenium Ingredients

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