Selenium status and its correlates in a British National Diet and Nutrition Survey: people aged 65 years and over

Bates, Christopher J.; Thane, Christopher W.; Prentice, Ann; Delves, H. T.

doi:10.1016/s0946-672x(02)80002-5

Cited by 105 publications

(97 citation statements)

References 38 publications

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“…In contrast to a study with British elderly subjects (Bates et al, 2002), plasma selenium was not correlated with plasma Selenium and antioxidants in elderly women M Wolters et al cholesterol, vitamin levels or anthropometric variables in our sample. An association of selenium status with blood lipids was reported previously (Navarro-Alarcon et al, 1999;Lee et al, 2003).…”

Section: Discussioncontrasting

confidence: 99%

“…Serum selenium below 1.2 mmol/l has been reported to be associated with reduced immune function in adult UK subjects (Broome et al, 2004). Other scientists have reported even lower mean selenium concentrations than in our sample in elderly adults, especially in institutionalized elderly people (Navarro-Alarcon et al, 1999;Bates et al, 2002). A suboptimal selenium status has also been observed in other European countries (Murphy and Cashman, 2002;Borawska et al, 2004).…”

Section: Discussionsupporting

confidence: 45%

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Selenium and antioxidant vitamin status of elderly German women

et al. 2005

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Objective: Low antioxidant intake and status have been shown to be associated with an elevated risk for various diseases. Data on the status of antioxidant vitamins, selenium and coenzyme Q10 of younger female seniors are scarce. The aim of this study was to assess the status of these antioxidants, as well as influencing factors such as dietary intake, anthropometric data and educational level in female seniors (60-70 years) in Germany. Design: Dietary intake of alpha-tocopherol, beta-carotene and ascorbic acid was determined by a 3-day diet record. Serum concentrations of alpha-tocopherol, beta-carotene, ascorbic acid, selenium and coenzyme Q10 were measured. Anthropometric measures, socioeconomic and educational status were assessed. Setting: In total, 178 elderly women without severe diseases in the region of Hannover, Germany, were included in the study. The mean (7s.d.) age and BMI of the women was 63.2 (2.73) years and 25.6 (3.77) kg/m 2 , respectively. The study participants were generally better educated than the overall German female population. Results: Dietary intake of the ascorbic acid and alpha-tocopherol was below RDA in six and 75% of the women, respectively. In comparison to estimated desirable serum concentrations of alpha-tocopherol, ascorbic acid, beta-carotene and selenium, lower concentrations were found in 23, 1, 6, and 39% of the women, respectively. Ascorbic acid (r ¼ 0.205, P ¼ 0.009) and betacarotene (r ¼ 0.173, P ¼ 0.025) intake were significantly associated with serum concentrations. Beta-carotene concentrations were influenced by the type of diet, BMI, and school education (R 2 ¼ 0.128, Po0.001). Serum selenium was positively associated with alcohol intake (r ¼ 0.229, P ¼ 0.003). Neither employment nor vocational training was predictive for the serum concentrations of antioxidant vitamins, selenium or coenzyme Q10. Conclusions: Poor status of selenium and alpha-tocopherol is highly prevalent even among younger, well-educated female seniors, whereas ascorbic acid and beta-carotene status seems sufficient in most women.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 45%

Selenium and antioxidant vitamin status of elderly German women

et al. 2005

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“…Low selenium has not usually been considered as a possible cause of anemia in older adults (Balducci, 2003;Guralnik et al, 2004) and has only been previously implicated in anemia among patients on hemodialysis (Hampel et al, 1985) or with pulmonary tuberculosis (van Lettow et al, 2005). However, a correlation between low plasma selenium concentrations and low hemoglobin had already been noted in the British National Diet and Nutrition Survey among 1134 men and women aged 65 years and older (Bates et al, 2002), and more recently low serum selenium was found to be associated with anemia among older disabled women living in the community . A potential biological mechanism by which low selenium could contribute to anemia is through maintenance of an optimal concentration of glutathione peroxidase, a key antioxidant selenoenzyme, in erythrocytes (Chow and Chen, 1980).…”

Section: Discussionmentioning

confidence: 99%

“…Selenium is a component of selenoproteins, including selenoenzymes such as glutathione peroxidase, selenoprotein-P and thioredoxin reductase (Zimmermann and Köhrle, 2002;Moghadaszadeh and Beggs, 2006). Serum selenium concentrations seem to decrease with age (Savarino et al, 2001;Bates et al, 2002) and are lower in persons with chronic diseases (Bates et al, 2002). Low serum selenium concentrations have been associated with increased mortality from cancer (Kok et al, 1987;Kornitzer et al, 2004) and all-cause mortality among older women living in the community .…”

Section: Introductionmentioning

confidence: 99%

Low serum selenium is associated with anemia among older adults in the United States

Ferrucci

et al. 2007

Eur J Clin Nutr

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Objective: We hypothesized that low serum selenium was associated with anemia in humans. Subjects: A total of 2092 adults aged 65 and older, in the third National Nutrition Examination Survey, Phase 2 (1991-1994) (NHANES III). Methods: Examination of the relationship between serum selenium and hematological indices in NHANES III. Results: Anemia, defined by World Health Organization criteria, was present in 12.9%. Mean serum selenium among non-anemic and anemic adults was 1.60 and 1.51 mmol l À1 (P ¼ 0.0003). The prevalence of anemia among adults in the lowest to highest quartiles of serum selenium was 18.3, 9.5, 9.7 and 6.9%, respectively (P ¼ 0.0005). The proportion of adults in the lowest quartile of selenium among those who were non-anemic or who had anemia due to nutritional causes, chronic inflammation, renal disease or unexplained anemia was 9.9, 27.5, 17.5, 24.0 and 15.4%, respectively. An increase in log e selenium was associated with a reduced risk of anemia (odds ratio per one standard deviation increase 0.75, 95% confidence interval 0.58-0.97, P ¼ 0.03), adjusting for age, race, education, body mass index and chronic diseases. Conclusion: Low serum selenium is independently associated with anemia among older men and women in the United States.

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“…It is a component of selenoproteins, including selenoenzymes such as glutathione peroxidase, selenoprotein-P and thioredoxin reductase (1). Serum selenium concentrations seem to decrease with age (2,3) and are lower in persons with cancer and chronic diseases (3). Low serum/plasma selenium concentrations have been associated with increased mortality from cancer (4,5) and increased all-cause mortality among community-dwelling older men and women in France (6) and women in the USA (7).…”

Section: Introductionmentioning

confidence: 99%

Low plasma selenium concentrations and mortality among older community-dwelling adults: the InCHIANTI Study

Lauretani

Semba²,

Bandinelli

et al. 2008

Aging Clin Exp Res

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Aims-We examined the relationship between plasma selenium levels at enrollment and all-cause mortality over a 6-year period among participants in the InCHIANTI study.Methods-1042 men and women ≥65 years from the InCHIANTI study, a population-based study of older adults living in the Chianti region of Tuscany, a population-based cohort in Tuscany, Italy. Plasma selenium was measured at enrollment (1998)(1999)(2000), and vital status was ascertained until May 2006.Results-During follow-up, 237 participants (22.7%) died. At enrollment, mean (SD) plasma selenium concentrations among participants who survived or died were 0.96 (0.14) and 0.87 (0.18) µmol/L (p<0.0001), respectively. The proportion of participants who died, from lowest to highest quartile of selenium, was 41.3, 27.0, 18.1 and 13.5% (p<0.0001 by Mantel-Haenszel chi-square). After adjusting for age, sex, education, and chronic diseases, adults in the lowest quartile of plasma selenium at enrollment had higher mortality compared with those in the highest quartile (Hazard Ratio (HR) 1.60, 95% Confidence Interval (CI) 1.04-2.47, p=0.034).Conclusion-Low plasma selenium may be an independent predictor of mortality among older adults living in the community.

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Selenium status and its correlates in a British National Diet and Nutrition Survey: people aged 65 years and over

Cited by 105 publications

References 38 publications

Selenium and antioxidant vitamin status of elderly German women

Selenium and antioxidant vitamin status of elderly German women

Low serum selenium is associated with anemia among older adults in the United States

Low plasma selenium concentrations and mortality among older community-dwelling adults: the InCHIANTI Study

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