Selenium Supplementation Enhances the Expression of Interleukin 2 Receptor Subunits and Internalization of Interleukin 2

Roy, Marie‐Josée; Kiremidjian-Schumacher, L.; Wishe, H. I.; Cohen, M. W.; Stotzky, G.

doi:10.3181/00379727-202-43538

Cited by 59 publications

(37 citation statements)

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“…Given the time frame, it is possible that selenate or its metabolites are involved in modulating extrathymic T cell maturation after xenograft in adult but not young mice. In fact, dietary selenium is known to up-regulate CD25-expressed T cells, an indicator of T cell activation, in humans and mice [30][31][32][33]. In contrast, dietary selenium deficiency promotes tumorigenesis at the onset of tumor development (days 11-17), which is consistent with the observation that dietary selenium deficiency does not affect the weight of full-blown tumors [24].…”

Section: Discussionsupporting

confidence: 68%

Nutritional and supranutritional levels of selenate differentially suppress prostate tumor growth in adult but not young nude mice

Holmström¹,

Ryan²,

Zeng³

et al. 2012

The Journal of Nutritional Biochemistry

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Section: Discussionsupporting

confidence: 68%

Nutritional and supranutritional levels of selenate differentially suppress prostate tumor growth in adult but not young nude mice

Holmström¹,

Ryan²,

Zeng³

et al. 2012

The Journal of Nutritional Biochemistry

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“…Increased expression of the synthesis machinery may be required for increased production of selenoproteins themselves, or for protein factors that poise lymphocytes for stronger proliferative capacity. For example, dietary (2.0 ppm Se for 8 weeks) supplementation of mice or ex vivo (100 nM Se as sodium selenite) supplementation of cell cultures resulted in increased expression of the IL-2 receptor a subunit (CD25) and increased proliferative capacity of concanavalin-A-stimulated mouse lymphocytes (210). Our laboratory conducted studies on primary CD4…”

Section: The Effects Of Se Intake On Camentioning

confidence: 99%

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

715

496

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Dietary selenium (]Se), mainly through its incorporation into selenoproteins, plays an important role in inflammation and immunity. Adequate levels of Se are important for initiating immunity, but they are also involved in regulating excessive immune responses and chronic inflammation. Evidence has emerged regarding roles for individual selenoproteins in regulating inflammation and immunity, and this has provided important insight into mechanisms by which Se influences these processes. Se deficiency has long been recognized to negatively impact immune cells during activation, differentiation, and proliferation. This is related to increased oxidative stress, but additional functions such as protein folding and calcium flux may also be impaired in immune cells under Se deficient conditions. Supplementing diets with above-adequate levels of Se can also impinge on immune cell function, with some types of inflammation and immunity particularly affected and sexually dimorphic effects of Se levels in some cases. In this comprehensivearticle, the roles of Se and individual selenoproteins in regulating immune cell signaling and function are discussed. Particular emphasis is given to how Se and selenoproteins are linked to redox signaling, oxidative burst, calcium flux, and the subsequent effector functions of immune cells. Data obtained from cell culture and animal models are reviewed and compared with those involving human physiology and pathophysiology, including the effects of Se levels on inflammatory or immune-related diseases including anti-viral immunity, autoimmunity, sepsis, allergic asthma, and chronic inflammatory disorders. Finally, the benefits and potential adverse effects of intervention with Se supplementation for various inflammatory or immune disorders are discussed. Antioxid. Redox Signal. 16, 705-743.

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“…The reasoning for our focus on the IL-2R lies in the fact that increased levels of Se in humans have been demonstrated to enhance the expression of both the ␣ (CD25) and ␤ plus ␥ (CD122/CD132) subunits of the IL-2R, which resulted in a greater number of high affinity IL-2R per cell and enhanced proliferation and differentiation of T cells (28,29). In addition, IL-2/IL-2R interactions play key roles in the proliferation and differentiation of CD4 ϩ T cells during immune responses such as those that occur during allergic asthma (30).…”

Section: Expression Of Cd25 On Cd4 ϩ T Cells From Ova-challenged Lungmentioning

confidence: 99%

A Role for Dietary Selenium and Selenoproteins in Allergic Airway Inflammation

Hoffmann

Saux

Hoffmann

et al. 2007

The Journal of Immunology

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Asthma is driven by allergic airway inflammation and involves increased levels of oxidative stress. This has led to speculation that antioxidants like selenium (Se) may play important roles in preventing or treating asthma. We fed diets containing low (0.08 parts per million), medium (0.25 parts per million), or high (2.7 parts per million) Se to female C57BL/6 mice and used an established OVA challenge protocol to determine the relationship between Se intake and the development of allergic airway inflammation. Results demonstrated that mice fed medium levels of Se had robust responses to OVA challenge in the lung as measured by lung cytokine levels, airway cellular infiltrate, eosinophilia, serum anti-OVA IgE, airway hyperreactivity, goblet cell hyperplasia, and phosphorylated STAT-6 levels in the lung. In contrast, responses to OVA challenge were less robust in mice fed low or high levels of Se. In particular, mice fed low Se chow showed significantly lower responses compared with mice fed medium Se chow for nearly all readouts. We also found that within the medium Se group the expression of lung glutathione peroxidase-1 and liver selenoprotein P were increased in OVA-challenged mice compared with PBS controls. These data suggest that Se intake and allergic airway inflammation are not related in a simple dose-response manner, which may explain the inconsistent results obtained from previous descriptive studies in humans. Also, our results suggest that certain selenoproteins may be induced in response to Ag challenges within the lung.

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Selenium Supplementation Enhances the Expression of Interleukin 2 Receptor Subunits and Internalization of Interleukin 2

Cited by 59 publications

References 0 publications

Nutritional and supranutritional levels of selenate differentially suppress prostate tumor growth in adult but not young nude mice

Nutritional and supranutritional levels of selenate differentially suppress prostate tumor growth in adult but not young nude mice

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

A Role for Dietary Selenium and Selenoproteins in Allergic Airway Inflammation

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