Selenium supplementation improves the nutritional status of hemodialysis patients: a randomized, double-blind, placebo-controlled trial

Salehi, Mousa; Sohrabi, Zahra; Ekramzadeh, Maryam; Fallahzadeh, Mohammad Kazem; Ayatollahi, Maryam; Geramizadeh, Bita; Hassanzadeh, Jafar; Sagheb, Mohammad Mahdi

doi:10.1093/ndt/gfs170

Cited by 82 publications

(67 citation statements)

References 42 publications

(69 reference statements)

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“…We found that selenium supplementation among women with PCOS has resulted in a significant reduction in plasma MDA levels, but it could not affect plasma TAC and GSH levels. Similarly, Salehi et al [54] demonstrated a significant decrease in MDA levels after administration of 200 μg selenium supplements per day for 12 weeks among hemodialysis patients. Furthermore, vitamin E-plus-selenium combination decreased MDA concentrations in streptozotocin-induced diabetic rats [55].…”

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confidence: 88%

Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

et al. 2015

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Selenium supplementation could be effective on reproductive outcomes, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS). The aim of the study was to determine the effects of selenium supplementation on reproductive outcomes, biomarkers of inflammation, and oxidative stress in PCOS patients. The present randomized double-blind, placebo-controlled trial was conducted on 64 women aged 18?40 years old with PCOS at the clinic affiliated to Ardabil University of Medical Sciences, Ardabil, Iran. The participants were randomly assigned to 2 groups receiving either 200??g selenium daily (n=32) or placebo (n=32) for 8 weeks. Hormonal profiles, biomarkers of inflammation, and oxidative stress were measured and compared both before and after the treatment. After 8 weeks of intervention, pregnancy rate in the selenium group was higher than in the placebo group: 18.8 (6/32) vs. 3.1% (1/32), p=0.04. In addition, alopecia (40.6 vs. 9.4%, p=0.004) and acne (46.9 vs. 12.5 %, p=0.003) decreased following the consumption of selenium supplements compared with placebo. Additionally, patients who received selenium supplements had significantly decreased serum dehydroepiandrosterone (DHEA) levels (p=0.02), hirsutism (modified Ferriman?Gallwey scores) (p<0.001), serum high sensitivity C-reactive protein (hs-CRP) (p=0.02), and plasma malondialdehyde (MDA) levels (p=0.01) compared with placebo. We did not observe any significant effects of taking selenium supplements on other hormonal profiles, nitric oxide (NO), and other biomarkers of oxidative stress. Taken together, selenium supplementation for 8 weeks among PCOS women had beneficial effects on reproductive outcomes, DHEA, hs-CRP, and MDA levels.

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confidence: 88%

Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

et al. 2015

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“…Upon collection, serum glucose and lipoproteins were determined by enzymatic methods (calorimeter) using a Biosystem A25 analyzer. We measured serum malondialdehyde (MDA) by the modified thiobarbituric acid method (spectrophotometric method) (18) and used commercially available ELISA kits to determine serum concentration of high-sensitivity C-reactive protein (hs-CRP) (IBL international GmbH, Flughafenstrasse 52a, D-22335 Germany), adiponectin (Boster Biological Technology Ltd), IL-6 (AviBion, Orgenium Laboratories), and insulin (Monobind Inc., Lake Forest, CA 92630, USA). We evaluated the insulin resistance by homeostasis model assessment calculated as:…”

Section: Methodsmentioning

confidence: 99%

Cranberry Supplement and Metabolic Risk Factors in Obese and Overweight Females

Eftekhari¹,

Allaei²,

Khosropanah³

et al. 2016

Jentashapir J Health Res

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“…KBY hastalarında antioksidanlardan zengin beslenme ile oksidatif stresin azaldığı da bildirilmektedir (43). Yapılan bir çalışmada, antiinflamatuvar besin desteği alan KBY hastalarında oksidatif stres ve inflamasyonun azaldığı gözlenmiştir (44). Diyet antioksidanları ve oksidatif stres arasındaki ilişkiyi değerlendiren bir başka çalışmada da, antioksidan beslenme ile oksidatif stres seviyelerinin azaldığı bildirilmiştir (45).…”

Section: Mıa Sendromunun Tedavisinde Yeni Stratejilerunclassified

The Malnutrition-Inflammation-Atherosclerosis (MIA) Syndrom

Küçükkatırcı¹,

Şanlıer²

2016

Turk Neph Dial Transpl

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ÖzSon dönem böbrek yetmezliği (SDBY) olan hastalarda malnütrisyon, inflamasyon ve ateroskleroz gelişimi oldukça fazla görülmekte ve her bir parametre kendi başına mortalite ve morbidite oranını artırmaktadır. İlk olarak 2000 yılında ortaya atılan malnütrisyon-inflamasyon-ateroskleroz (MIA) sendromunun temelini, SDBY hastalarında serum proinflamatuvar sitokin düzeylerindeki artış ve bu hastalarda sıklıkla görülen malnütrisyon ve ateroskleroz arasındaki ilişki oluşturmaktadır. SDBY hastalarında proinflamatuvar sitokin seviyelerinin artmasıyla anoreksiyanın da arttığı ve bu durumun malnütrisyona zemin hazırladığı bilinmektedir. Aynı zamanda sitokin seviyelerindeki artışa bağlı olarak ortaya çıkan kronik inflamasyon hızlanmış ateroskleroza neden olabilmektedir. MIA sendromunun bileşenlerinin görülme oranının artmasıyla hastaların yaşam süreleri ve kaliteleri azalmaktadır. Bu nedenle derlemede; MIA sendromunun bileşenleri, bileşenlerin birbiriyle etkileşimi ve her bir bileşenle etkin mücadele etmek için izlenecek yollar hakkında bilgi vermek amaçlanmıştır.anahtar sözcükler: Böbrek yetmezliği, Malnütrisyon, İnflamasyon, Ateroskleroz, Beslenme durumu abStRact Development of malnutrition, inflammation and atherosclerosis are commonly seen in end-stage renal disease (ESRD) patients and the rates of mortality and morbidity are increased by each parameter. The basis of the malnutrition-inflammation-atherosclerosis (MIA) syndrome that has been proposed in 2000 for the first time is the relationship between increased serum levels of proinflammatory cytokine, malnutrition and atherosclerosis that are commonly seen in ESRD patients. The increase of proinflammatory cytokine levels in ESRD patients increases the anorexia and this is known to predispose to malnutrition. At the same time, it is reported that chronic inflammation due to elevated cytokine levels causes accelerated atherosclerosis. The life expectancy and quality of life of patients decreases with the increasing incidence of the components of the MIA syndrome. In this review, we aimed to explain the components of the MIA syndrome, the interactions of these components and effective treatment of each component.

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Selenium supplementation improves the nutritional status of hemodialysis patients: a randomized, double-blind, placebo-controlled trial

Cited by 82 publications

References 42 publications

Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

Cranberry Supplement and Metabolic Risk Factors in Obese and Overweight Females

The Malnutrition-Inflammation-Atherosclerosis (MIA) Syndrom

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