Selenium supplementation in patients with subclinical hypothyroidism affected by autoimmune thyroiditis: Results of the SETI study

Pirola, Ilenia; Rotondi, Mario; Cristiano, Alessandra; Maffezzoni, Filippo; Pasquali, Daniela; Marini, F; Coperchini, Francesca; Paganelli, Matteo; Apostoli, Pietro; Chiovato, Luca; Ferlin, Alberto; Cappelli, Carlo

doi:10.1016/j.endien.2019.12.002

Cited by 16 publications

(16 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Contrarily, selenium deficiency, by impairing deiodinases activity, decreases the synthesis of triiodothyronine (T3) [ 18 , 30 , 31 ]. At present, more and more studies have shown a beneficial effect of selenium supplementation on AIT and other autoimmune disorders such as asthma and rheumatoid arthritis by the improvement of autoimmune response [ 4 , 5 , 12 , 14 , 15 , 32 – 34 ]. A study conducted by Mantovani et al showed oral selenium supplementation had an effect in reducing TPOAb concentrations and the recurrence of postpartum thyroiditis during pregnancy [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Wu et al reported that the incidence of AIT is higher in the areas with selenium deficiency, but the exact mechanism remains unclear [10]. Recently, excessive oxidative stress has been implicated in the pathogenesis of AIT, and some authors support the opinion of selenium deficiency in the development of AIT and the potentially beneficial effects of selenium supplementation on AIT [11][12][13][14]. However, the underlying mechanisms of slowing down and preventing the development of AIT have not been fully clarified, and some studies even contrastly showed the different even opposite results.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis

Tian

et al. 2020

International Journal of Endocrinology

View full text Add to dashboard Cite

Objective. Selenium, as an antioxidant, has been implicated in the development of autoimmune thyroiditis (AIT). Many studies showed selenium supplementation could decrease thyroid autoantibodies in patients with AIT. However, the underlying mechanisms have not been well determined. Therefore, we performed a clinical study to investigate the possible mechanism of beneficial effects of selenium treatment on AIT patients. Methods. Forty euthyroid patients with AIT were randomized into two groups. Group I was treated with 200 μg/day selenium supplementation, and group II received a placebo over a 3-month period. Thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), antithyroglobulin antibody (TgAb), malondialdehyde (MDA), total antioxidant capacity (TAC), and superoxide dismutase (SOD) were measured before and 3 months after treatments. Additionally, twenty healthy volunteers also served as a control group for the evaluation of such parameters in basic condition. Results. Totally, 32 patients (group I, n = 18; group II, n = 14) completed the clinical study and were incorporated into the statistics. MDA level was higher and SOD activity and TAC were lower in patients compared to healthy individuals. After 3 months, TPOAb titer significantly decreased within group I (P<0.001) but did not change within group II (P=0.001). There were also no statistically significant changes in TSH and TgAb titers within the two groups (all P>0.05). Additionally, decreased MDA level (from 6.8 ± 1.3 nmol/ml to 4.9 ± 0.7 nmol/ml; P<0.001) and increased TAC (from 10.0 ± 1.9 mmol/l to 12.9 ± 3.1 mmol/l; P=0.003) and SOD activity (from 72.3 ± 10.3 U/ml to 84.3 ± 13.2 U/ml; P=0.007) were simultaneously observed after 3 months’ selenium treatment. Moreover, there was a negative correlation between TAC and TgAb/TPOAb and a positive correlation between MDA and TgAb/TPOAb in AIT patients. Conclusions. Our findings support the hypothesis that selenium treatment could decrease TPOAb titer via enforcing the defense against oxidative stress in euthyroid patients with AIT, which may be a potential underlying mechanism.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis

Tian

et al. 2020

International Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…The relation between autoimmunity and other systemic diseases has been for a long time examined by worldwide literature (28)(29)(30), moreover focusing on new therapeutic implications in both surgical and medical field (31)(32)(33)(34)(35)(36)(37)(38). The pathogenesis of autoimmune disorders is due to genetic (4-7, 23-25, 39-41), stochastic (42), and environmental (43)(44)(45)(46)(47)(48)(49) factors.…”

Section: Gut Microbiome and Autoimmunitymentioning

confidence: 99%

The Human Microbiota in Endocrinology: Implications for Pathophysiology, Treatment, and Prognosis in Thyroid Diseases

et al. 2020

Self Cite

View full text Add to dashboard Cite

The human microbiota is an integral component in the maintenance of health and of the immune system. Microbiome-wide association studies have found numerous diseases associated to dysbiosis. Studies are needed to move beyond correlations and begin to address causation. Autoimmune thyroid diseases (ATD) are one of the most common organ-specific autoimmune disorders with an increasing prevalence, higher than 5% worldwide. Most frequent manifestations of ATD are Hashimoto’s thyroiditis and Graves’ disease. The exact etiology of ATD remains unknown. Until now it is not clear whether bacterial infections can trigger ATD or modulate the efficacy of treatment and prognosis. The aim of our review is to characterize the microbiota and in ATD and to evaluate the impact of dysbiosis on treatment and prognosis. Moreover, variation of gut microbiome has been associated with thyroid cancer and benign nodules. Here we will characterize the microbioma in benign thyroid nodules, and papillary thyroid cancer to evaluate their implications in the pathophysiology and progression.

show abstract

“…In 2020, a study on selenium supplementation in patients with subclinical hypothyroidism was published by Pirola et al [68] . The study included the analysis of thyroid hormones and thyroid peroxidase antibodies, selenium and iodine.…”

Section: Selected Publications In the Development Of The Pathogenesismentioning

confidence: 99%

Global view on the pathogenesis of benign thyroid disease based on historical, experimental, biochemical and genetic data, identifying the role of magnesium, selenium, coenzyme Q10 and iron in the context of the unfolded protein response and protein quality control of thyroglobulin

Moncayo¹,

Moncayo²,

J³

2020

jtgg

View full text Add to dashboard Cite

show abstract

Selenium supplementation in patients with subclinical hypothyroidism affected by autoimmune thyroiditis: Results of the SETI study

Cited by 16 publications

References 28 publications

Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis

Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis

The Human Microbiota in Endocrinology: Implications for Pathophysiology, Treatment, and Prognosis in Thyroid Diseases

Global view on the pathogenesis of benign thyroid disease based on historical, experimental, biochemical and genetic data, identifying the role of magnesium, selenium, coenzyme Q10 and iron in the context of the unfolded protein response and protein quality control of thyroglobulin

Contact Info

Product

Resources

About