Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop

Fraga-Silva, Thais Fernanda de Campos; Mimura, Luiza Ayumi Nishiyama; Oliveira, Larissa Ragozo Cardoso de; Toledo, Juliana Helena dos Santos de; Borim, Patrícia Aparecida; Zorzella-Pezavento, Sofia Fernanda Gonçalves; Alonso, Diego Peres; Ribolla, Paulo Eduardo Martins; Oliveira, Carlos Alberto Ferreira de; Fonseca, Denise Morais da; Villablanca, Eduardo J.; Sartori, Alexandrina

doi:10.1038/s41598-020-79102-7

Cited by 9 publications

(4 citation statements)

References 89 publications

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“…Fraga-Silva et al (166) showed that the administration of Saccharomyces cerevisiae enriched with Se (Selemax) reduced the prevalence of EAE, increased the number of CD103 + dendritic cells and reduced the intestinal inflammatory process compared to the administration of Saccharomyces cerevisiae alone. In addition, Selemax supplementation demonstrated a neuroprotective effect by increasing the expression of protein tau in the CNS.…”

Section: Selenium Microbiota and Neurological Diseasesmentioning

confidence: 99%

“…In addition, Selemax supplementation demonstrated a neuroprotective effect by increasing the expression of protein tau in the CNS. Tau is the main protein associated with the stability of neuronal microtubules along with the MAPs (MAP1 and MAP2) (166). Long-term dietary supplementation (3 months) with Seenriched yeast (Se-yeast) in triple transgenic mouse model of Alzheimer disease (AD), significantly improved spatial learning, retention of neuronal memory and activity (167).…”

Section: Selenium Microbiota and Neurological Diseasesmentioning

confidence: 99%

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Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases

et al. 2021

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This review covers current knowledge of selenium in the dietary intake, its bioavailability, metabolism, functions, biomarkers, supplementation and toxicity, as well as its relationship with diseases and gut microbiota specifically on the symbiotic relationship between gut microflora and selenium status. Selenium is essential for the maintenance of the immune system, conversion of thyroid hormones, protection against the harmful action of heavy metals and xenobiotics as well as for the reduction of the risk of chronic diseases. Selenium is able to balance the microbial flora avoiding health damage associated with dysbiosis. Experimental studies have shown that inorganic and organic selenocompounds are metabolized to selenomethionine and incorporated by bacteria from the gut microflora, therefore highlighting their role in improving the bioavailability of selenocompounds. Dietary selenium can affect the gut microbial colonization, which in turn influences the host's selenium status and expression of selenoproteoma. Selenium deficiency may result in a phenotype of gut microbiota that is more susceptible to cancer, thyroid dysfunctions, inflammatory bowel disease, and cardiovascular disorders. Although the host and gut microbiota benefit each other from their symbiotic relationship, they may become competitors if the supply of micronutrients is limited. Intestinal bacteria can remove selenium from the host resulting in two to three times lower levels of host's selenoproteins under selenium-limiting conditions. There are still gaps in whether these consequences are unfavorable to humans and animals or whether the daily intake of selenium is also adapted to meet the needs of the bacteria.

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Section: Selenium Microbiota and Neurological Diseasesmentioning

confidence: 99%

Section: Selenium Microbiota and Neurological Diseasesmentioning

confidence: 99%

Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases

et al. 2021

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“…In the context of MS, supplementation with the probiotic S. cerevisiae has been shown to ameliorate symptoms and the Th1 response in the central nervous system of experimental autoimmune encephalomyelitis (EAE) models. Furthermore, it increases the production of regulatory T cells and enhances microbiota diversity [46]. Other species of the genus Saccharomyces, such as Saccharomyces boulardii, have been suggested to reduce fatigue, pain and inflammation, promote mental health, and improve the quality of life in pwMS [47].…”

Section: Discussionmentioning

confidence: 99%

Bacteria–Fungi Interactions in Multiple Sclerosis

Gorostidi-Aicua,

Reparaz,

Otaegui-Chivite

et al. 2024

Microorganisms

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Multiple sclerosis (MS) arises from a complex interplay between host genetic factors and environmental components, with the gut microbiota emerging as a key area of investigation. In the current study, we used ion torrent sequencing to delve into the bacteriome (bacterial microbiota) and mycobiome (fungal microbiota) of people with MS (pwMS), and compared them to healthy controls (HC). Through principal coordinate, diversity, and abundance analyses, as well as clustering and cross-kingdom microbial correlation assessments, we uncovered significant differences in the microbial profiles between pwMS and HC. Elevated levels of the fungus Torulaspora and the bacterial family Enterobacteriaceae were observed in pwMS, whereas beneficial bacterial taxa, such as Prevotelladaceae and Dialister, were reduced. Notably, clustering analysis revealed overlapping patterns in the bacteriome and mycobiome data for 74% of the participants, with weakened cross-kingdom interactions evident in the altered microbiota of pwMS. Our findings highlight the dysbiosis of both bacterial and fungal microbiota in MS, characterized by shifts in biodiversity and composition. Furthermore, the distinct disease-associated pattern of fungi–bacteria interactions suggests that fungi, in addition to bacteria, contribute to the pathogenesis of MS. Overall, our study sheds light on the intricate microbial dynamics underlying MS, paving the way for further investigation into the potential therapeutic targeting of the gut microbiota in MS management.

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“…[1] Although the etiology of MS is not well understood, its neuropathological features include demyelination, gliosis, and chronic axonal injury. [2] Moreover, T cell subsets, specially Th1, Th17, and cytotoxic T cells are strongly implicated in the pathogenesis of MS. [3] Lymphocyte infiltration and activation, as well as the microglial and astrocyte activation persist as the defining feature of contemporary MS lesion categorization. [4] Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for studying human MS, which can help to define the contribution of immune events to the development of MS. [5] Currently, FDA-approved MS therapies act through regulating or inhibiting the peripheral immune response, such as interferon (IFN)-𝛽, dimethyl fumarate, mitoxantrone, glatiramer acetate, and alemtuzumab.…”

Section: Introductionmentioning

confidence: 99%

A High MCT‐Based Ketogenic Diet Suppresses Th1 and Th17 Responses to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice by Inhibiting GSDMD and JAK2‐STAT3/4 Pathways

Zhang,

Sun,

Wang

et al. 2023

Molecular Nutrition Food Res

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ScopeInflammation and pyroptosis play important roles in the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). In this study, we evaluated the therapeutic potential of ketogenic diet (KD) in EAE.Methods and resultsThe administration of KD reduces demyelination and microglial activation in the spinal cord of EAE mice. Meanwhile, KD decreases the levels of Th1 and Th17 associated cytokines/transcription factors production (T‐bet, IFN‐γ, RORγt, and IL‐17) and increases those of Th2 and Treg cytokines/transcription factors (GATA3, IL‐4, Foxp3, and IL‐10) in the spinal cord and spleen. Corresponding, KD reduces the expression of chemokines in EAE, which those chemokines associate with T‐cell infiltration into central nervous system (CNS). In addition, KD inhibits the GSDMD activation in microglia, oligodendrocyte, CD31+ cells, CCR2+ cells, and T cells in the spinal cord. Moreover, KD significantly decreases the ratios of p‐JAK2/JAK2, p‐STAT3/STAT3, and p‐STAT4/STAT4, as well as GSDMD in EAE mice.Conclusionsthis study demonstrates that KD reduces the activation and differentiation of T cells in the spinal cord and spleen and prevents T cell infiltration into CNS of EAE via modulating the GSDMD and STAT3/4 pathways, suggesting that KD is a potentially effective strategy in the treatment of MS.

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Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop

Cited by 9 publications

References 89 publications

Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases

Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases

Bacteria–Fungi Interactions in Multiple Sclerosis

A High MCT‐Based Ketogenic Diet Suppresses Th1 and Th17 Responses to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice by Inhibiting GSDMD and JAK2‐STAT3/4 Pathways

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