Selenoneine ameliorates peroxide-induced oxidative stress in C. elegans

Rohn, Isabelle; Kroepfl, Nina; Aschner, Michael; Bornhorst, Julia; Kuehnelt, Doris; Schwerdtle, Tanja

doi:10.1016/j.jtemb.2019.05.012

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…The physiological functions of SeN remain poorly elucidated. SeN has strong radical scavenging and antioxidant activity, and most researchers agree that this may be its primary function (12,68,75,76) . Indeed, it was shown to be more resistant to irreversible oxidative degradation compared to ergothioneine and engages in reversible oxidation and reduction reaction under conditions that irreversibly degrade ergothioneine (77) .…”

Section: Case Study: Selenoneine and Se Status Among Nunavimmiutmentioning

confidence: 99%

Emerging evidence on selenoneine and its public health relevance in coastal populations: a review and case study of dietary Se among Inuit populations in the Canadian Arctic

Little,

Achouba,

Ayotte

et al. 2024

Nutr. Res. Rev.

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Selenium is an essential mineral yet both deficiency and excess are associated with adverse health effects. Dietary intake of Se in humans varies greatly between populations due to food availability, dietary preferences, and local geological and ecosystem processes impacting Se accumulation into agricultural products and animal populations. We argue there is a need to evaluate and reconsider the relevance of public health recommendations on Se given recent evidence, including the metabolic pathways and health implications of Se. This argument is particularly pertinent for Inuit populations in Northern Canada, who often exceed dietary tolerable upper intake levels and exhibit very high whole blood Se concentrations due to their dependence on local country foods high in the newly discovered Se compound, selenoneine. Since selenoneine appears to have lower toxicity compared to other Se species and does not contribute to the circulating pools of Se for selenoprotein synthesis, we argue that total dietary Se or total Se in plasma or whole blood are poor indicators of Se adequacy for human health in these populations. Overall, this review provides an overview of the current evidence of Se speciation, deficiency, adequacy, and excess and implications for human health and dietary recommendations, with particular reference to Inuit populations in the Canadian Arctic and other coastal populations consuming marine foods.

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Section: Case Study: Selenoneine and Se Status Among Nunavimmiutmentioning

confidence: 99%

Emerging evidence on selenoneine and its public health relevance in coastal populations: a review and case study of dietary Se among Inuit populations in the Canadian Arctic

Little,

Achouba,

Ayotte

et al. 2024

Nutr. Res. Rev.

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show abstract

“…Owing to the fact that a number of synthetic organoselenium compounds have been synthesized for their use as redox-modulators in the last few years [39][40][41], the antioxidant activity of compounds (3a, 3g, 3i) are further estimated employing different biochemical assays such as DPPH, bleomycin-dependent DNA damage and Gpx-like assays [42,43].…”

Section: ]mentioning

confidence: 99%

New organoselenides (NSAIDs-Se derivatives) as potential anticancer agents: Synthesis, biological evaluation and in silico calculations

Nie

Zhong

et al. 2021

European Journal of Medicinal Chemistry

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“…They measured the 50% radical-scavenging concentration with 1-diphenyl-2-picrylhydrazyl for the water-soluble vitamin E-like antioxidant Trolox, l-ergothioneine, and the reduced selenoneine form, and the results were 880, 1700, and 1.9 μM, respectively, indicating that selenoneine has a greater antioxidant activity than Trolox and 1-ergothioneine [ 10 ]. Selenoneine attenuates peroxide-induced oxidative stress in C. elegans [ 13 ] and methylmercury-mediated toxicity in zebrafish embryo and human cells [ 14 ]. Recently, dietary supplementation of selenoneine-containing tuna dark muscle extract has been shown to effectively reduce the pathology of experimental colorectal cancers in mice [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Selenoneine Ameliorates Hepatocellular Injury and Hepatic Steatosis in a Mouse Model of NAFLD

et al. 2020

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Selenoneine is a novel organic selenium compound markedly found in the blood, muscles, and other tissues of fish. This study aimed to determine whether selenoneine attenuates hepatocellular injury and hepatic steatosis in a mouse model of non-alcoholic fatty liver disease (NAFLD). Mice lacking farnesoid X receptor (FXR) were used as a model for fatty liver disease, because they exhibited hepatomegaly, hepatic steatosis, and hepatic inflammation. Fxr-null mice were fed a 0.3 mg Se/kg selenoneine-containing diet for four months. Significant decreases in the levels of hepatomegaly, hepatic damage-associated diagnostic markers, hepatic triglycerides, and total bile acids were found in Fxr-null mice fed with a selenoneine-rich diet. Hepatic and blood clot total selenium concentrations were 1.7 and 1.9 times higher in the selenoneine group than in the control group. A marked accumulation of selenoneine was found in the liver and blood clot of the selenoneine group. The expression levels of oxidative stress-related genes (heme oxygenase 1 (Hmox1), glutathione S-transferase alpha 1 (Gsta1), and Gsta2), fatty acid synthetic genes (stearoyl CoA desaturase 1(Scd1) and acetyl-CoA carboxylase 1 (Acc1)), and selenoprotein (glutathione peroxidase 1 (Gpx1) and selenoprotein P (Selenop)) were significantly decreased in the selenoneine group. These results suggest that selenoneine attenuates hepatic steatosis and hepatocellular injury in an NAFLD mouse model.

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Selenoneine ameliorates peroxide-induced oxidative stress in C. elegans

Cited by 9 publications

References 18 publications

Emerging evidence on selenoneine and its public health relevance in coastal populations: a review and case study of dietary Se among Inuit populations in the Canadian Arctic

Emerging evidence on selenoneine and its public health relevance in coastal populations: a review and case study of dietary Se among Inuit populations in the Canadian Arctic

New organoselenides (NSAIDs-Se derivatives) as potential anticancer agents: Synthesis, biological evaluation and in silico calculations

Selenoneine Ameliorates Hepatocellular Injury and Hepatic Steatosis in a Mouse Model of NAFLD

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