Self-administration of intravenous C1-inhibitor therapy for hereditary angioedema and associated quality of life benefits

Bygum, Anette; Andersen, Klaus Ejner; Mikkelsen, Carsten Sauer

doi:10.1684/ejd.2008.0603

Cited by 120 publications

(120 citation statements)

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“…3,14 Evidence for Home Therapy in Pediatric HAE Home therapy in HAE has been demonstrated to be effective and well tolerated in adults, allowing early treatment of attacks and improved quality of life. [5][6][7][8] The feasibility of this approach in pediatric patients is less well established. There is a single retrospective observational study examining the efficacy and safety of home therapy in 20 pediatric HAE patients.…”

Section: Rationale For Home Therapy For Pediatric Haementioning

confidence: 99%

“…[5][6][7][8] However, the experience in pediatric home therapy is extremely limited, and some experts have proposed that acute care would be best provided by medical professionals, with home therapy serving as an emergency contingency plan in the case that no expert help is available. 1 Parents or patients who undertake home therapy are essentially accepting a partial transfer in responsibility of care from their physician, and they must understand and consent to this.…”

Section: Limitations To Home Therapy For Pediatric Haementioning

confidence: 99%

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Hereditary Angioedema: Moving Therapy into the Home and to Self-Care

BetschelStephen

JagdisAmanda

2014

Pediatric Allergy, Immunology, and Pulmonology

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Hereditary angioedema (HAE) is a condition that results in recurrent and often unpredictable attacks of angioedema, which is associated with significant morbidity and can be fatal. The majority of literature related to management of HAE has focused on the adult patient. There is limited information on treatment and management strategies for the pediatric HAE population. Comprehensive care has been repeatedly recommended in international guidelines for the optimal management of HAE. Home therapy is a critical pillar of such a comprehensive care plan. Hemophilia is similar to HAE in that it is a serious rare blood disorder for which comprehensive care is considered essential. There is a paucity of literature on home therapy as it relates to the pediatric HAE patient population. This review outlines the rationale for home therapy in the management of pediatric HAE by drawing on the experience in pediatric hemophilia and placing it in the specific context of HAE management principles.

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Section: Rationale For Home Therapy For Pediatric Haementioning

confidence: 99%

Section: Limitations To Home Therapy For Pediatric Haementioning

confidence: 99%

Hereditary Angioedema: Moving Therapy into the Home and to Self-Care

BetschelStephen

JagdisAmanda

2014

Pediatric Allergy, Immunology, and Pulmonology

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“…Training of the patient and the family can be accomplished by the home infusion specialist provided by the specialty pharmacies in the United States or by physicians and their extenders if home infusion specialists are not available. 1,16,18,19 Despite the potential need for frequent i.v. therapies, central dwelling catheters should be avoided due to the risk of infection and thrombosis associated with indwelling catheters.…”

Section: Treatment Of Haementioning

confidence: 99%

Treatment of Hereditary Angioedema in the Pediatric Patient

Kalaria

Craig²

2014

Pediatric Allergy, Immunology, and Pulmonology

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“…Several recent studies, however, have suggested that early home infusion of C1INH provides a superior outcome compared with treatment at a medical facility [29][30][31][32][33][34], probably due to shortening the interval between onset of symptoms and institution of effective therapy. As a result, a recent HAE international home therapy consensus recommends that every patient with physician-diagnosed HAE be considered for physician-supervised, selfmanaged home C1INH replacement therapy, and that therapy be initiated as soon as the patient notices the first symptoms of an HAE attack [32].…”

Section: Treatment Of Hereditary Angioedema Attacksmentioning

confidence: 99%

The New Era of C1-Esterase Inhibitor Deficiency Therapy

Tourangeau

Zuraw

2011

Curr Allergy Asthma Rep

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Hereditary angioedema (HAE) is an autosomal dominant disorder clinically characterized by recurrent episodes of angioedema. Until late-2008, HAE therapy in the United States was largely limited to antifibrinolytic agents or attenuated androgens. Although these drugs decrease the number and severity of angioedema attacks, they are associated with significant dose-related adverse effects. Recent advances have dramatically changed the management of HAE. As a result, we are embarking on a new era of treatment for this condition that includes effective on-demand treatment of attacks as well as effective prophylactic treatment. Herein we discuss the various treatment options for C1-inhibitor deficiency, focusing on new developments and literature published over the past year, as well as the additional patient considerations that should be addressed when determining the most appropriate patient-specific treatment plan.

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Self-administration of intravenous C1-inhibitor therapy for hereditary angioedema and associated quality of life benefits

Cited by 120 publications

References 0 publications

Hereditary Angioedema: Moving Therapy into the Home and to Self-Care

Hereditary Angioedema: Moving Therapy into the Home and to Self-Care

Treatment of Hereditary Angioedema in the Pediatric Patient

The New Era of C1-Esterase Inhibitor Deficiency Therapy

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