2022
DOI: 10.1016/j.actbio.2022.09.066
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Self-amplified chain-shattering cinnamaldehyde-based poly(thioacetal) boosts cancer chemo-immunotherapy

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Cited by 20 publications
(15 citation statements)
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“…42,43 Therefore, PDTAs have found extensive applications in bio-related fields where controlled degradation is desired, such as targeted drug delivery and tissue engineering. 26,37,[44][45][46][47][48][49][50] In particular, all these recent studies indicate the huge potential and the increasing importance of PDTA in terms of synthetic polymer chemistry.…”
Section: Introductionmentioning
confidence: 99%
“…42,43 Therefore, PDTAs have found extensive applications in bio-related fields where controlled degradation is desired, such as targeted drug delivery and tissue engineering. 26,37,[44][45][46][47][48][49][50] In particular, all these recent studies indicate the huge potential and the increasing importance of PDTA in terms of synthetic polymer chemistry.…”
Section: Introductionmentioning
confidence: 99%
“…9,18 Furthermore, they have been incorporated into polymeric backbones as repeating units to form poly(thioacetal)s and poly(thioketal)s for ROS-responsive degradation of the entire polymer matrices. 14,19,[20][21][22][23] Nano-sized particles based on poly (thioacetal)s and poly(thioketal)s showed excellent selectivity to ROS-rich tissues and were used for targeted delivery of various druggable molecules. 14,16,19,20,23 However, despite the attractive chemical properties and applicable potential, there is a lack of common synthetic methods for introducing thioacetals or thioketals into polymers.…”
Section: Introductionmentioning
confidence: 99%
“…Such stepgrowth polymerization inevitably resulted in polymers with broad molecular weight distributions (MWDs) or low average molecular weights (M n < 3 kDa). 15,16,20,21,28 These polymers are difficult to be applied to the construction of delicate polymeric architectures, whose morphology is an important factor determining their physiological behaviours. 29 In this study, we report the first example of chain-growth polymerization for the synthesis of well-defined poly(thioacetal)s and poly(thioketal), which overcomes the limitations of previous step-growth polymerization methods.…”
Section: Introductionmentioning
confidence: 99%
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“…They are widely used as A2 type monomers for synthesizing linear polymers with B2 type monomers, hyperbranched polymers with three or more functional monomers, and crosslinked materials with multiple functional polymers. Dithiols can also be used in to synthesize other polymers, such as polythioacetal, 24–26 polythioketal, 27 and polythioester. 28 Although the synthesis technology of dithiols has flourished, the development of dithiol reagents has lagged behind.…”
Section: Introductionmentioning
confidence: 99%