Self-Assembled 2D Free-Standing Janus Nanosheets with Single-Layer Thickness

Lin, Yiyang; Thomas, Michael R.; Gelmi, Amy; Leonardo, Vincent; Pashuck, E. Thomas; Maynard, Stephanie A.; Wang, Ye; Stevens, Molly M.

doi:10.1021/jacs.7b06591

Cited by 111 publications

(111 citation statements)

References 35 publications

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“…Equipped with biotin, 1e is designed for selective detection of biotin-binding proteins, such as streptavidin, a tetrameric protein with an astonishingly high affinity to bind biotin. 40,41 Grafting biotin onto different sensing platforms [42][43][44][45] has been reported for a variety of bioanalytical applications. However, functionalization of organic semiconductors with biotin is challenging because the hydrogen bonds from biotin can change the molecular packing of organic semiconductors impairing p-p interactions.…”

Section: Sensing Of Streptavidinmentioning

confidence: 99%

Functionalized π Stacks of Hexabenzoperylenes as a Platform for Chemical and Biological Sensing

Zhang

et al. 2018

Chem

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This study puts forth an unusual type of p stacking that allows a variety of functional groups to be grafted onto organic semiconductors without sacrificing p-p interactions in the solid state. As a result of this type of p stacking, the selfassembly of functionalized hexabenzoperylenes (HBPs) provides a general sensing platform, which has been demonstrated to enable highly sensitive and selective detection of fluoride ions and streptavidin in water when HBPs are functionalized with silyl ether and biotin, respectively. SUMMARYOne challenge in tailoring organic semiconductors for sensing applications is that the introduction of reactive groups or binding sites usually impairs p-p interactions. To meet this challenge, this study puts forth an unusual type of p stacking that allows a variety of functional groups to be grafted onto organic semiconductors without sacrificing p-p interactions in the solid state. As a result of this type of p stacking, the self-assembly of functionalized hexabenzoperylenes (HBPs) provides a general sensing platform for various chemical and biological species. This supramolecular platform, in a device integrating an organic field-effect transistor channel and a microfluidic channel, has enabled highly sensitive and selective detection of fluoride ions and streptavidin in water when HBPs are equipped with a cleavable Si-O bond and a biotin moiety, respectively. Figure 1. Structures of Functionalized HBPs 1a-1e and Unfunctionalized HBP 2

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Section: Sensing Of Streptavidinmentioning

confidence: 99%

Functionalized π Stacks of Hexabenzoperylenes as a Platform for Chemical and Biological Sensing

Zhang

et al. 2018

Chem

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“…Driven by entropic interaction, the self-assembly of 2D nanodiscs can produce a fascinating variety of LC structures ranging from orientationally ordered nematic (N) to positionally ordered structures, including lamellar (L) and columnar (C) phases with positional order in 1 and 2 dimensions, respectively (4). These superstructures with controlled ordering have emerged as promising paradigms addressing challenges in energy storage (5), controlled drug delivery (6,7), and self-healing materials (8). For example, by controlling liquid-crystalline alignment of 2D titanium carbide (MXene), researchers have demonstrated thicknessindependent capacitance of vertically aligned nanosheet-based film (5).…”

mentioning

confidence: 99%

Iridescence in nematics: Photonic liquid crystals of nanoplates in absence of long-range periodicity

Zeng

King

Huang

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Photonic materials with positionally ordered structure can interact strongly with light to produce brilliant structural colors. Here, we found that the nonperiodic nematic liquid crystals of nanoplates can also display structural color with only significant orientational order. Owing to the loose stacking of the nematic nanodiscs, such colloidal dispersion is able to reflect a broad-spectrum wavelength, of which the reflection color can be further enhanced by adding carbon nanoparticles to reduce background scattering. Upon the addition of electrolytes, such vivid colors of nematic dispersion can be fine-tuned via electrostatic forces. Furthermore, we took advantage of the fluidity of the nematic structure to create a variety of colorful arts. It was expected that the concept of implanting nematic features in photonic structure of lyotropic nanoparticles may open opportunities for developing advanced photonic materials for display, sensing, and art applications.

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“…KFF is composed of amino acids having a predilection for aggregation. The peptide or protein sequences reported to form extended 2D nanostructures are phenylalanineand tyrosine-rich (32)(33)(34). Although it would be highly premature to say that these amino acids have a propensity to form nanosheets, such reports and results of the present study certainly indicate that these amino acids may be of importance in inducing nanosheet formation.…”

Section: Overexpressed Tumor Antigens Form Amyloid Nanosheetsmentioning

confidence: 63%

Ovalbumin self-assembles into amyloid nanosheets that elicit immune responses and facilitate sustained drug release

Tufail

Sherwani

Shoaib

et al. 2018

Journal of Biological Chemistry

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Amyloids are associated with many neurodegenerative diseases, motivating investigations into their structure and function. Although not linked to a specific disease, albumins have been reported to form many structural aggregates. We were interested in investigating host immune responses to amyloid fibrils assembled from the model protein ovalbumin. Surprisingly, upon subjecting ovalbumin to standard denaturing conditions, we encountered giant protein nanosheets harboring amyloid-like features and hypothesized that these nanosheets might have potential in clinical or therapeutic applications. We found that the nanosheets, without the administration of any additional adjuvant, evoked a strong antibody response in mice that was higher than that observed for native ovalbumin. This suggests that amyloid nanosheets have a self-adjuvanting property. The nanosheet-induced immune response was helper T cell 2 (Th2) biased and negligibly inflammatory. While testing whether the nanosheets might form depots for the sustained release of precursor proteins, we did observe release of ovalbumin that mimicked the conformation of native protein. Moreover, the nanosheets could load the anticancer drug doxorubicin and release it in a slow and sustained manner. Taken together, our results suggest that amyloid nanosheets should be further investigated as either an antigen delivery vehicle or a multifunctional antigen and drug co-delivery system, with potential applications in simultaneous immunotherapy and chemotherapy.

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Self-Assembled 2D Free-Standing Janus Nanosheets with Single-Layer Thickness

Cited by 111 publications

References 35 publications

Functionalized π Stacks of Hexabenzoperylenes as a Platform for Chemical and Biological Sensing

Functionalized π Stacks of Hexabenzoperylenes as a Platform for Chemical and Biological Sensing

Iridescence in nematics: Photonic liquid crystals of nanoplates in absence of long-range periodicity

Ovalbumin self-assembles into amyloid nanosheets that elicit immune responses and facilitate sustained drug release

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