Self‐Assembled Collagen Microparticles by Aerosol as a Versatile Platform for Injectable Anisotropic Materials

Lama, Miléna; Fernandes, Francisco M.; Marcellan, Alba; Peltzer, Juliette; Trouillas, Marina; Banzet, Sébastien; Grosbot, Marion; Sánchez, Clément; Giraud‐Guille, Marie‐Madeleine; Lataillade, Jean‐Jacques; Boissière, Cédric; Nassif, Nadine

doi:10.1002/smll.201902224

Cited by 17 publications

(21 citation statements)

References 36 publications

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“…While this may include biological or synthetic polymers [ 3 ], we focus here on type I collagen, which is of particular relevance for designing biomimetic ECMs as it is a major constituent of connective tissues [ 4 , 5 ]. Many different processes have been used to shape collagen while preserving its native conformation [ 6 ], including extrusion [ 7 ], aerosols [ 8 ], electrospinning [ 9 ] and freeze-drying technologies [ 10 ]. High magnetic field has also been used to control collagen alignment, as collagen fibrils orient perpendicularly to the field direction [ 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials

et al. 2021

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Major progress in the field of regenerative medicine is expected from the design of artificial scaffolds that mimic both the structural and functional properties of the ECM. The bionanocomposites approach is particularly well fitted to meet this challenge as it can combine ECM-based matrices and colloidal carriers of biological cues that regulate cell behavior. Here we have prepared bionanocomposites under high magnetic field from tilapia fish scale collagen and multifunctional silica nanoparticles (SiNPs). We show that scaffolding cues (collagen), multiple display of signaling peptides (SiNPs) and control over the global structuration (magnetic field) can be combined into a unique bionanocomposite for the engineering of biomaterials with improved cell performances.

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Section: Introductionmentioning

confidence: 99%

Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials

et al. 2021

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“…Purified acidic (molecular) collagen solutions were prepared from rat tail tendons (see the “Experimental Section”). As depicted in Figure 1 a, dense collagen microparticles were produced by spray drying [ 27 ] and mixed with acetic acid aqueous solution. The rationale in using this method is that a simple weighing of the collagen microparticles determines the concentration of the gel.…”

Section: Setting a Palette Of 3d Biomimetic Collagen Gels As Tissue Amentioning

confidence: 99%

“…Here, we propose a simple manufacturing method to prepare type I collagen gels as models to study the intricate interplay between collagen fibril to suprafibrillar self‐assembly and mechanical response in biological materials. We capitalize on the previously described process to prepare non‐denatured collagen microparticles by spray drying [ 27 ] to produce 3D tissue‐like collagen gels in terms of fibrillar microstructure. The approach is bioinspired, relying on the secretion of collagen by cells to form the ECM.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Tough Gels with Weak Bonds Unravel the Role of Collagen from Fibril to Suprafibrillar Self‐Assembly

Lama

Raveendranathan

Brun

et al. 2021

Macromolecular Bioscience

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Biological tissues rich in type I collagen exhibit specific hierarchical fibrillar structures together with remarkable mechanical toughness. However, the role of collagen alone in their mechanical response at different structural levels is not fully understood. Here, it is proposed to rationalize such challenging interplay from a materials science perspective through the subtle control of this protein self‐assembly in vitro. It is relied on a spray‐processing approach to readily use the collagen phase diagram and set a palette of biomimetic self‐assembled collagen gels in terms of suprafibrillar organization. Their mechanical responses unveil the involvement of mechanisms occurring either at fibrillar or suprafibrillar scales. Noticeably, both modulus at early stage of deformations and tensile toughness probe the suprafibrillar organization, while durability under cyclic loading and stress relaxation reflect mechanisms at the fibril level. By changing the physicochemical environment, the interfibrillar interactions are modified toward more biomimetic mechanical responses. The possibility of making tissue‐like materials with versatile compositions and toughness opens perspectives in tissue engineering.

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“…While this may include biological or synthetic polymers [3], we focus here on type I collagen, which is of particular relevance for designing biomimetic ECMs as it is a major constituent of connective tissues [4,5]. Many different processes have been used to shape collagen while preserving its native conformation [6], including extrusion [7], aerosols [8], electrospinning [9] and freeze-drying technologies [10]. High magnetic field has also been used to control collagen alignment, as collagen fibrils orient perpendicularly to the field direction [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials

Debons¹,

Matsumoto²,

Hirota³

et al. 2021

Preprint

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Major progress in the field of regenerative medicine are expected from the design of artificial scaffolds that mimic both the structural and functional properties of the ECM. The bionanocomposites approach is particularly well fitted to meet this challenge as it can combine ECM-based matrices and colloidal carriers of biological cues that regulate cell behavior. Here we have prepared bionanocomposites under high magnetic field from Tilapia fish scale collagen and multifunctional silica nanoparticles (SiNPs). We show that scaffolding cues (collagen), multiple display of signaling peptides (SiNPs) and control over the global structuration (magnetic field) can be combined into a unique bionanocomposite for the engineering of biomaterials with improved cell performances.

show abstract

Self‐Assembled Collagen Microparticles by Aerosol as a Versatile Platform for Injectable Anisotropic Materials

Cited by 17 publications

References 36 publications

Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials

Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials

Biomimetic Tough Gels with Weak Bonds Unravel the Role of Collagen from Fibril to Suprafibrillar Self‐Assembly

Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials

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