Self-assembled hyaluronic acid nanoparticles for osteoarthritis treatment

Kang, Li‐Jung; Yoon, Jong Han; Rho, Jun Gi; Han, Hwa Seung; Lee, Seulbi; Oh, Young Soo; Kim, Hwan; Kim, Eunha; Kim, Seok Jung; Lim, Yong Taik; Park, Jae Hyung; Song, Woo Keun; Yang, Siyoung; Kim, Wook

doi:10.1016/j.biomaterials.2021.120967

Cited by 83 publications

(62 citation statements)

References 45 publications

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“…In addition to abnormal mechanical stress, excessive production of pro-inflammatory cytokines can also cause chondrocyte damage, leading to the biodegradation and synthesis imbalance of ECM [ [42] , [43] , [44] ]. Type II collagen (Col2) and aggrecan are the principal constituents of cartilage ECM synthesized by chondrocytes and can be degraded by matrix metalloproteinase 13 (MMP13) and A disintegrin and metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5) in osteoarthritis conditions [ [45] , [46] , [47] , [48] ].…”

Section: Resultsmentioning

confidence: 99%

Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis

Lei

Wang

Liao

et al. 2022

Bioactive Materials

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Section: Resultsmentioning

confidence: 99%

Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis

Lei

Wang

Liao

et al. 2022

Bioactive Materials

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“…In addition, it has been reported that the HA nanoparticles have potential as nanomedicine in the treatment of inflammatory diseases ( Rao et al, 2020 ). Kang et al (2021 )reported an empty self-assembled HA nanoparticle (HA-NP) as a potential therapeutic agent in osteoarthritis treatment: HA nanoparticles blocked the receptor-mediated cellular uptake of free HA with low molecular weight, and the cellular uptake of HA nanoparticles was increased by the ectopic expression of CD44, using an adenoviral delivery system; HA nanoparticles presented in vitro resistance to digestion with hyaluronidase and in vivo long-term retention ability in knee joint, compared with free HA with a high molecular weight. Lierova et al (2020 )found that HA nanoparticles could reduce harmful radiation-induced processes in lung tissue, thereby potentially decreasing ECM degradation leading to pulmonary fibrosis.…”

Section: Biomaterials Prepared With Hyaluronic Acidmentioning

confidence: 99%

Advances in Hyaluronic Acid for Biomedical Applications

Yasin

Ren

et al. 2022

Front. Bioeng. Biotechnol.

109

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Hyaluronic acid (HA) is a large non-sulfated glycosaminoglycan that is the main component of the extracellular matrix (ECM). Because of its strong and diversified functions applied in broad fields, HA has been widely studied and reported previously. The molecular properties of HA and its derivatives, including a wide range of molecular weights but distinct effects on cells, moisture retention and anti-aging, and CD44 targeting, promised its role as a popular participant in tissue engineering, wound healing, cancer treatment, ophthalmology, and cosmetics. In recent years, HA and its derivatives have played an increasingly important role in the aforementioned biomedical fields in the formulation of coatings, nanoparticles, and hydrogels. This article highlights recent efforts in converting HA to smart formulation, such as multifunctional coatings, targeted nanoparticles, or injectable hydrogels, which are used in advanced biomedical application.

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“…By conjugating the Col II-targeting peptide (WYRGRL) on the surface of the metal−organic framework (MOF)-decorated mesoporous polydopamine, this nanoparticle actively targeted the Col II chain in cartilage ECM and exhibited anti-oxidation and anti-apoptosis capability with the ability to impede cartilage degradation in OA [ 199 ]. Moreover, some nanoparticles display specific physicochemical properties that respond to chemical, light, thermal, and magnetic stimuli, playing roles in aiding drug infiltration and symptom relief [ 200 , 201 ].…”

Section: Articular Cartilage Regeneration Under Abnormal Conditionsmentioning

confidence: 99%

Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions

Wang

et al. 2022

Bioactive Materials

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The development of interdisciplinary biomedical engineering brings significant breakthroughs to the field of cartilage regeneration. However, cartilage defects are considerably more complicated in clinical conditions, especially when injuries occur at specific sites ( e.g. , osteochondral tissue, growth plate, and weight-bearing area) or under inflammatory microenvironments ( e.g. , osteoarthritis and rheumatoid arthritis). Therapeutic implantations, including advanced scaffolds, developed growth factors, and various cells alone or in combination currently used to treat cartilage lesions, address cartilage regeneration under abnormal conditions. This review summarizes the strategies for cartilage regeneration at particular sites and pathological microenvironment regulation and discusses the challenges and opportunities for clinical transformation.

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Self-assembled hyaluronic acid nanoparticles for osteoarthritis treatment

Cited by 83 publications

References 45 publications

Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis

Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis

Advances in Hyaluronic Acid for Biomedical Applications

Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions

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