Self-assembled nanomaterials for ferroptosis-based cancer theranostics

Ma, Guiqi; Wang, Kaiqi; Pang, Xinlong; Xu, Shanbin; Gao, Yuan; Liang, Yanliang; Yang, Jiaxin; Zhang, Xinyu; Sun, Xiao; Dong, Jian

doi:10.1039/d2bm02000a

Cited by 9 publications

(5 citation statements)

References 93 publications

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“…64 Ferroptosis in tumour cells is mainly related to ROS-induced lipid peroxidation. 65 Generally, iron-catalysed ROS production limits its low efficiency in the TME, where a Fe 2+ -led Fenton reaction often requires a large amount of H 2 O 2 and low pH. There is an antioxidant defence system within tumour cells, which may also reduce the performance of ferroptosis.…”

Section: Piezocatalytic Therapy Combined With Ferroptosismentioning

confidence: 99%

A metal–organic framework-integrated composite for piezocatalysis-assisted tumour therapy: design, related mechanisms, and recent advances

Wang,

Liu,

Quan

et al. 2024

Biomater. Sci.

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Section: Piezocatalytic Therapy Combined With Ferroptosismentioning

confidence: 99%

A metal–organic framework-integrated composite for piezocatalysis-assisted tumour therapy: design, related mechanisms, and recent advances

Wang,

Liu,

Quan

et al. 2024

Biomater. Sci.

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“…Recent advances in ferroptosis-based self-assembled anti-cancer nanomaterials have emphasized their detailed mechanisms for inducing ferroptosis in tumor cells and their unique advantages [179]. Therefore, delineating the molecular mechanisms under the ferroptosis inducing nanomedicine studies is a must to pave the way for future challenges and opportunities.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Inducing ferroptosis via nanomaterials: a novel and effective route in cancer therapy

Ensoy,

Ozturk,

Cansaran-Duman

et al. 2024

J. Phys. Mater.

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The use of nanomaterials for cancer ferroptosis presents a promising avenue for research and clinical applications. The unique properties of nanomaterials, such as their small size, large surface area, and ability to be engineered for specific tasks, make them ideal candidates for ferroptosis inducing cancer therapies. Ferroptosis is a new type of cell death mechanism that is distinct from apoptosis and necrosis. It has been shown to be critical in the treatment of various tumors. The ferroptotic mechanism has been mainly linked with the regulation of iron, amino acid, glutathione, and lipid metabolism of cells. The relationship between ferroptosis mechanisms and cancer nanomedicine has attracted considerable interest in recent years. It has been reported that the combination of nanomedicine and ferroptosis can achieve high therapeutic efficacy for the treatment of different cancer types. This review will provide an overview of recent work in ferroptosis-related cancer nanomedicine. First, general information is given about the definition of ferroptosis and its differences from other cell death mechanisms. Later, studies exploring the role of ferroptosis in the cancer nanomedicine field are discussed in detail. Specific focus has been given to the use of combinatorial treatment strategies which combine ferroptosis with chemodynamic therapy, photodynamic therapy, photothermal therapy, immunotherapy and sonodynamic therapy. Considering the fact that ferroptosis inducing nanoparticles have already been introduced into clinical studies, nanoscientists can further accelerate this clinical translation as they tailor the physicochemical characteristics of nanomaterials. This review provides enlightening information for all researchers interested in the molecular characterization and relationship between ferroptosis and cancer-directed nanoparticles.

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“…Fe@OVA-IR820 induces Fe 3+ -dependent ferroptosis-triggered ICD, which releases endogenous neoantigens and DAMPs that work synergistically with the exogenous antigen ovalbumin (OVA) to provoke an immune response. The photothermal effect of near-infrared irradiation further amplifies these immune responses ( Ma G. et al, 2023 ). The increased recruitment and infiltration of T cells suppresses the primary tumor.…”

Section: Induction Of Ferroptosis As a Novel Approach To Treat Melanomamentioning

confidence: 99%

Ferroptosis as a promising therapeutic strategy for melanoma

Ta,

Jiang,

Zhang

et al. 2023

Front. Pharmacol.

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Malignant melanoma (MM) is the most common and deadliest type of skin cancer and is associated with high mortality rates across all races and ethnicities. Although present treatment options combined with surgery provide short-term clinical benefit in patients and early diagnosis of non-metastatic MM significantly increases the probability of survival, no efficacious treatments are available for MM. The etiology and pathogenesis of MM are complex. Acquired drug resistance is associated with a pool prognosis in patients with advanced-stage MM. Thus, these patients require new therapeutic strategies to improve their treatment response and prognosis. Multiple studies have revealed that ferroptosis, a non-apoptotic form of regulated cell death (RCD) characterized by iron dependant lipid peroxidation, can prevent the development of MM. Recent studies have indicated that targeting ferroptosis is a promising treatment strategy for MM. This review article summarizes the core mechanisms underlying the development of ferroptosis in MM cells and its potential role as a therapeutic target in MM. We emphasize the emerging types of small molecules inducing ferroptosis pathways by boosting the antitumor activity of BRAFi and immunotherapy and uncover their beneficial effects to treat MM. We also summarize the application of nanosensitizer-mediated unique dynamic therapeutic strategies and ferroptosis-based nanodrug targeting strategies as therapeutic options for MM. This review suggests that pharmacological induction of ferroptosis may be a potential therapeutic target for MM.

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Self-assembled nanomaterials for ferroptosis-based cancer theranostics

Abstract: Recent advances in ferroptosis-based self-assembled anti-cancer nanomaterials are summarized, with particular emphasis on their detailed mechanisms for inducing ferroptosis in tumor cells as well as their unique advantages and future challenges.

Cited by 9 publications

References 93 publications

A metal–organic framework-integrated composite for piezocatalysis-assisted tumour therapy: design, related mechanisms, and recent advances

A metal–organic framework-integrated composite for piezocatalysis-assisted tumour therapy: design, related mechanisms, and recent advances

Inducing ferroptosis via nanomaterials: a novel and effective route in cancer therapy

Ferroptosis as a promising therapeutic strategy for melanoma

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