Self-assembled nanoparticles with bilirubin/JPH203 alleviate imiquimod-induced psoriasis by reducing oxidative stress and suppressing Th17 expansion

A double-edged sword: ROS related therapies in the treatment of psoriasis

“… [73] Bilirubin/JPH203 IMQ-induced Ps mice Transdermal Weak toxicity while enhancing the therapeutic effect. [90] Gallic acid/ Rutin IMQ-induced Ps mice Transdermal Good entrapment of drug in the chitosan polymer and remarkable control drug release. [89] CeO 2 IMQ-induced Ps mice Transdermal The introduction of β-CDs improved the water solubility, biocompatibility and antioxidant properties of CeNPs owe to its porous nanostructures with unique hydrophobic cavity.…”

“…(I): BRNPs (Reproduced with permission from [73] , Copyright© 2020, Elsevier B.V.); (II): MBNs (Reproduced with permission from [88] , Copyright© 2022, The Royal Society of Chemistry). (III): A "sugar gourd"-like nanoplatform co-loaded with bilirubin and JPH203 (Reproduced with permission from [90] , Copyright© 2021 Elsevier B.V.). (IV): Ethosomes co-loaded with GA and Cur (Reproduced with permission from [91] , Copyright © 2021 Elsevier B.V.).…”

“…In another research, a "sugar gourd"-like nanoplatform realized the co-loading of bilirubin with the specific LAT1 inhibitor JPH203 ( Fig. 3 III) [90] . This co-loading plays the effects of bilirubin and JPH203 simultaneously, including scavenging ROS, inhibiting cell proliferation and reducing the secretion of inflammatory factors.…”

Alantolactone-loaded chitosan/hyaluronic acid nanoparticles suppress psoriasis by deactivating STAT3 pathway and restricting immune cell recruitment

“…Nanocarriers have shown advantages for drug delivery over conventional systems, including controlled release, increased solubility and stability, and enhanced delivery efficiency [18] , [19] , [20] . For example, Pukale et al reported lipid-polymer hybrid nanoparticles (LPNs) for clobetasol propionate delivery to treat psoriasis.…”

Hypochlorous acid triggered fluorescent probes forin situimaging of a psoriasis model

“…[5][6][7][8] Although some studies have identified the relationship between ROS and psoriasis, it remains unclear whether HOCl is expressed in the psoriasis region. 9,10 Therefore, we hope to clarify whether there is HOCl expression in the psoriasis skin. However, due to the lack of suitable tools, there are no reports on in situ imaging of ROS, especially certain types of ROS (e.g., HOCl) in the psoriasis model.…”