2021
DOI: 10.3390/cells10071734
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Self-Assembled Permanent Micro-Magnets in a Polymer-Based Microfluidic Device for Magnetic Cell Sorting

Abstract: Magnetophoresis-based microfluidic devices offer simple and reliable manipulation of micro-scale objects and provide a large panel of applications, from selective trapping to high-throughput sorting. However, the fabrication and integration of micro-scale magnets in microsystems involve complex and expensive processes. Here we report on an inexpensive and easy-to-handle fabrication process of micrometer-scale permanent magnets, based on the self-organization of NdFeB particles in a polymer matrix (polydimethyl… Show more

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Cited by 19 publications
(27 citation statements)
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“…1a). The composite approach has shown to be a powerful bottom-up method to fabricate magnetic sources with micrometric size and high density and integrate them into polymer-based microfluidic devices 30,31,34,35 . In particular, on-demand magnetic functions can be Please do not adjust margins Please do not adjust margins obtained using the magnetic composite approach by tailoring the magnetic powder composition (nature, size and morphology), the packing density and ordering (by applying a magnetic field pattern during the polymer reticulation), as well as the microfabrication technique 26 .…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…1a). The composite approach has shown to be a powerful bottom-up method to fabricate magnetic sources with micrometric size and high density and integrate them into polymer-based microfluidic devices 30,31,34,35 . In particular, on-demand magnetic functions can be Please do not adjust margins Please do not adjust margins obtained using the magnetic composite approach by tailoring the magnetic powder composition (nature, size and morphology), the packing density and ordering (by applying a magnetic field pattern during the polymer reticulation), as well as the microfabrication technique 26 .…”
Section: Resultsmentioning
confidence: 99%
“…The inner structure of a 1 mm 3 NdFeB@PDMS membrane was observed using the EasyTomNano μCT tomograph (RX Solutions), with a resolution of 0.3 μm. Detailed operation procedure can be found in 30,31 . Final images of 1700 x 1700 x 400 voxel, i.e 510 x 510 x 120 μm 3 , were obtained and processed with ImageJ to characterize NdFeB particles' spatial organization in the volume of the composite membrane.…”
Section: Device Fabrication and Integrationmentioning
confidence: 99%
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“…Furthermore, the combination of recent progressive development to considerably increase the permeability by using anisotropic agglomerates of magnetic particles in the polymer matrix can hold promises for further increase in performances of patterned magnetic microstructures. 29,30 Overall, the proposed approach allows simple, robust, and rapid fabrication of any complicated shape of magnetic microstructures for the microscale modulation of magnetic fields, showing an immense application potential in magnetic force-based microfluidic techniques.…”
Section: Discussionmentioning
confidence: 98%
“…The novel subject of this study is the induced interaction of the magnetic field with cells containing magnetic nanospheres. This gives many opportunities to manipulate cells, e.g., cause quantitative separation of cells or cell migration [ 10 , 11 , 12 ].…”
Section: Introductionmentioning
confidence: 99%