Self-assembled structures of alkanethiols on gold-coated cantilever tips and substrates for atomic force microscopy: Molecular organisation and conditions for reproducible deposition

Lamprou, Dimitrios A.; Smith, James R.; Nevell, Thomas G.; Barbu, Eugen; Willis, Caroline; Tsibouklis, John

doi:10.1016/j.apsusc.2009.10.045

Cited by 16 publications

(7 citation statements)

References 57 publications

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“…12 The AFM technique has been used to probe, in air, well defined alkanethiol self-assembled structures that had been attached to cleaned, gold-coated AFM tips and substrates. [13][14] For all alkanethiol self-assembled structures considered, values of interfacial energy ( TM ) were found to be in close agreement with those from CAG measurements. Towards the assessment of the breadth of the applicability of the technique, this paper compares the (3-glycidoxypropyl)trimethoxysilane (GPTMS, 97%, epoxy-terminated; Alfa Aesar, Heysham, UK), 3-(triethoxysilyl) propylsuccinic anhydride (TESPSA, 95%, CO 2 H-terminated; Wacker-Chemie GmbH, Burghausen, Germany) and trimethoxy(propyl)silane (TPS, 98+%, CH 3 -terminated; Alfa Aesar, Heysham, UK), Figure 1, were grafted onto AFM cantilevers and onto cleaned glass surfaces by immersion into a solution of the silane (APTES, 5%…”

Section: Introductionsupporting

confidence: 67%

“…Gold-coated glass microscope slides (Au.1000.ALSI, Platypus Technologies, Madison, Wisconsin, USA, cut to 1 25 cm × 1 25 cm) and gold-coated AFM cantilevers (NPG-20 'C' V-shaped cantilevers; Veeco Instruments SAS, Dourdan, France) were cleaned by immersion in Gold Surface Cleaning solution (thiourea 1% (w/v) in 10% aqueous sulphuric acid; Sigma-Aldrich, Poole, UK; 1 h and 5 min, respectively), rinsed (water, Millipore, 16.5 M cm) and dried (nitrogen). 13 Immediately after cleaning, gold-coated substrates and cantilevers, and glass substrates and silicon nitride cantilevers were immersed in poly(1H,1H,2H,2H-perfluorodecyl methacrylate) (PFDMA; 5% in 1,1,2-trichlorotrifluoroethane, 99.8%, Aldrich, Dorset, UK) 20 for 1 min.…”

Section: Polymer-coated Surfaces and Afm Cantileversmentioning

confidence: 99%

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Towards the Determination of Surface Energy at the Nanoscale: A Further Assessment of the AFM-Based Approach

Lamprou¹,

Smith²,

Nevell³

et al. 2010

J. Adv. Microsc. Res.

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Towards the validation of the atomic force microscopy-based approach to the determination of surface energy at the nanometer scale, this paper explores the applicability of the technique by comparing atomic force microscopy-derived surface energy values with those from conventional contact angle measurements from a range of self-assembled organosilane structures ((3-aminopropyl)triethoxysilane, (3-glycidoxypropyl)trimethoxysilane, 3-(triethoxysilyl)propylsuccinic anhydride and trimethoxy(propyl)silane) and also from films of an ultra-low-surface-energy polymer, poly(1H,1H,2H,2H-perfluorodecyl methacrylate). The close agreement between the two sets of data indicates the validity of the AFM method, while unique attributes are indicated by the high resolution (ca. 1000 atoms) that is inherent to the approach and by the capability to study materials that are not compatible with the probing liquids used for goniometric determinations.

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Section: Introductionsupporting

confidence: 67%

Section: Polymer-coated Surfaces and Afm Cantileversmentioning

confidence: 99%

Towards the Determination of Surface Energy at the Nanoscale: A Further Assessment of the AFM-Based Approach

Lamprou¹,

Smith²,

Nevell³

et al. 2010

J. Adv. Microsc. Res.

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“…The interest in these materials has developed greatly in recent years in no small part as a direct response to the needs of technology. 26,27 SAMs are typically formed by small organic molecules, which in some way are amphiphilic; they are typically limited to dimensions of less than a few nanometers. The amphiphilic or dual solubility character of a compound implies that it (1) adsorbs at any polar-apolar interface, reducing the interfacial tension, that is, the amount of work required to increase the area of the interface at standard conditions and (2) self-organizes in bulk into aggregates containing many molecules and having well-defined average shape and size.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Novel 3-Benzyloxy-4-Substituted-2- Azetidinones: Formation of a Hydrophobic Layer Via a Self-Organization Effect

Hassan

Soliman

2011

Phosphorus, Sulfur, and Silicon and the Related Elements

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We report the synthesis of new persulfide-spacer N-substituted-2-azetidinone-Dglucosamine in an attempt to potentially provide new antibiotics. The Schiff base ligands considered for this study were derived representative example, demonstrated a super hydrophobic layer formed via highly organized thioether spacers on gold as the adsorbate system through the formation of sulfur-gold bonds. The reported glucosides showed a moderate antifungal activity against Candida albicans while being slightly to moderately active against gram-positive and gram-negative bacteria used in this investigation at a concentration of 1 mg/mL dissolved in dimethyl sulfoxide.

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“…Initially, all cells were probed with un-functionalized cantilevers to demonstrate that the tip-surface interactions observed were indeed the hydrophobic interactions and not non-specific interactions. As noted in earlier works, the unmodified cantilevers are inert gold surfaces and the force spectroscopy represents the hydrophilic and non-specific interactions on the cell surface [51,52]. Data showing force maps for un-functionalized cantilevers are presented in the Supporting Information ( Figure S3).…”

Section: Cell Surface Hydrophobicity Using Force Spectroscopymentioning

confidence: 95%

Nanoscale Phenotypic Textures of Yersinia pestis Across Environmentally-Relevant Matrices

et al. 2020

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The persistence of bacterial pathogens within environmental matrices plays an important role in the epidemiology of diseases, as well as impacts biosurveillance strategies. However, the adaptation potentials, mechanisms for survival, and ecological interactions of pathogenic bacteria such as Yersinia pestis are largely uncharacterized owing to the difficulty of profiling their phenotypic signatures. In this report, we describe studies on Y. pestis organisms cultured within soil matrices, which are among the most important reservoirs for their propagation. Morphological (nanoscale) and phenotypic analysis are presented at the single cell level conducted using Atomic Force Microscopy (AFM), coupled with biochemical profiles of bulk populations using Fatty Acid Methyl Ester Profiling (FAME). These studies are facilitated by a novel, customizable, 3D printed diffusion chamber that allows for control of the external environment and easy harvesting of cells. The results show that incubation within soil matrices lead to reduction of cell size and an increase in surface hydrophobicity. FAME profiles indicate shifts in unsaturated fatty acid compositions, while other fatty acid components of the phospholipid membrane or surface lipids remained consistent across culturing conditions, suggesting that phenotypic shifts may be driven by non-lipid components of Y. pestis.

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Self-assembled structures of alkanethiols on gold-coated cantilever tips and substrates for atomic force microscopy: Molecular organisation and conditions for reproducible deposition

Cited by 16 publications

References 57 publications

Towards the Determination of Surface Energy at the Nanoscale: A Further Assessment of the AFM-Based Approach

Towards the Determination of Surface Energy at the Nanoscale: A Further Assessment of the AFM-Based Approach

Synthesis and Antimicrobial Activity of Novel 3-Benzyloxy-4-Substituted-2- Azetidinones: Formation of a Hydrophobic Layer Via a Self-Organization Effect

Nanoscale Phenotypic Textures of Yersinia pestis Across Environmentally-Relevant Matrices

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