Self-Assembled Supramolecular Structures as Catalysts for Reactions Involving Cationic Transition States

Abstract

Self-assembled supramolecular structures represent easily accessible systems for the study of enzyme-like catalysis. The hydrophobic cavities of the assemblies provide a distinct chemical environment that can lead to unusual chemo-and stereoselectivities. This review summarizes the application of such host structures in the catalysis of reactions involving cationic transition states and includes detailed discussion of mechanisms and substrate-host interactions. The literature up to April 2015 is covered. 1 Introduction 2 Molecular Capsules: Structures and Background 3 Catalyzed Reactions 4 Summary and Outlook

Activation of Primary and Secondary Benzylic and Tertiary Alkyl (sp3)C-F Bonds Inside a Self-Assembled Molecular Container

“…Catalysis inside closed binding pockets, much like inside enzymes, has been a challenging research area but in recent decades active supramolecular systems have been reported (Marchetti and Levine, 2011; Wiester et al, 2011; Raynal et al, 2014; Brown et al, 2015; Leenders et al, 2015; Zarra et al, 2015; Catti et al, 2016a,b; Cullen et al, 2016; Jans et al, 2016; Kuijpers et al, 2016; Levin et al, 2016; Otte, 2016; Wang et al, 2016, 2017; Bräuer et al, 2017; Ueda et al, 2017; Catti and Tiefenbacher, 2018; La Manna et al, 2018a). Drawing upon a multitude of structural classes such as coordination cages, metal-organic frameworks, and non-covalent assemblies, a whole series of reactions were successfully catalyzed.…”