2016
DOI: 10.1038/srep29461
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Self-assembled targeted nanoparticles based on transferrin-modified eight-arm-polyethylene glycol–dihydroartemisinin conjugate

Abstract: Poor delivery of insoluble anticancer drugs has so far precluded their clinical application. In this study, an efficient tumor targeted-nanoparticle delivery system, transferrin-eight-arm-polyethylene glycol–dihydroartemisinin nanoparticles (TF-8arm-PEG-DHA NPs) for the vehiculation of dihydroartemisinin (DHA) was first prepared and evaluated for its targeting efficiency and cytotoxicity in vitro and in vivo to Lewis lung carcinoma (LLC) cells, which overexpress transferrin receptors (TFRs). The synthesized TF… Show more

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Cited by 56 publications
(53 citation statements)
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“…In medicine, they are used as drug carriers encapsulating a broad range of therapeutic agents such as siRNA, drug molecules, proteins and peptides [24] leading to more efficient drug delivery into the target site. Nanoparticle drug delivery system offers advantages such as better bioavailability, efficacy, solubility and encapsulation of the drug compared to conventional systems [2, 3, 5, 6]. The choice of the carrier in a nanoparticle delivery system is crucial since it can affect protection, retention and bioavailability of the drug or the natural active ingredient.…”
Section: Introductionmentioning
confidence: 99%
“…In medicine, they are used as drug carriers encapsulating a broad range of therapeutic agents such as siRNA, drug molecules, proteins and peptides [24] leading to more efficient drug delivery into the target site. Nanoparticle drug delivery system offers advantages such as better bioavailability, efficacy, solubility and encapsulation of the drug compared to conventional systems [2, 3, 5, 6]. The choice of the carrier in a nanoparticle delivery system is crucial since it can affect protection, retention and bioavailability of the drug or the natural active ingredient.…”
Section: Introductionmentioning
confidence: 99%
“…PPQ tetraphosphate is highly soluble in water . However, DHA has almost no solubility in water but high solubility in ethanol. Thus, a two‐step extraction method with ethanol and water was designed for effective extraction of both active ingredients from the ACT drugs.…”
Section: Discussionmentioning
confidence: 99%
“…Nanocarriers with the size of 20-100 nm are considered best suitable for enhanced permeability and retention (EPR) effect (Svenson, 2016), while avoiding extravasation from normal blood vessels which occurs only with particles below 10 nm (Appelbe et al, 2016). This also avoids removal from the body through renal clearance for particles below 5 nm or elimination by the reticuloendothelial system (RES) which traps particles above 100 nm (Liu et al, 2016). Visualization of the ApoElli nanocarriers and determination of their size prior to removal of released drug molecules and the Apo nanocarriers without ellipticine were performed using TEM (Fig.…”
Section: Preparation Of Apoferritin-bound Ellipticine (Apoelli) Nanopmentioning
confidence: 99%