Self-assemblies of plasmonic gold/layered double hydroxides with highly efficient antiviral effect against the hepatitis B virus

Cârjă, Gabriela; Grosu, Elena Florentina; Petrarean, Catalina; Nichita, Norica

doi:10.1007/s12274-015-0851-6

Cited by 29 publications

(17 citation statements)

References 45 publications

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“…A PEG-stabilized AuNP was found to inhibit the HIV-1 fusion process in a dose-dependent manner through blocking the gp120–CD4 interaction [ 214 ]. AuNPs have also been assembled onto a layered double hydroxide surface to inhibit HBV [ 215 ]. Interestingly, AuNPs have been co-loaded with efaverinz, an NNRTI, into niosomes and then furthered loaded into a thermosensitive gel to create a complex superstructure for sustained release against HIV-1 infections [ 216 ].…”

Section: Nanotechnology Interventionsmentioning

confidence: 99%

Nanotechnology for virus treatment

et al. 2021

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Section: Nanotechnology Interventionsmentioning

confidence: 99%

Nanotechnology for virus treatment

et al. 2021

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“…[ 19,54 ] Nanomaterials act as replication inhibitors by delivering drugs [ 17,20,55,56 ] or trapping the virus. [ 57,58 ]…”

Section: Nanomaterials For Antivirus Strategiesmentioning

confidence: 99%

Recent Progress on Biomaterials Fighting against Viruses

Li¹,

Guo²,

Gao³

et al. 2021

Advanced Materials

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Viruses not only pose severe threats to public health, but also influence the development of society. Over the past decade, rapid advances have been seen in the application of nanomaterials to virus research. As an interdisciplinary field, nanotechnology offers powerful functions because the structures of nanomaterials are unique, with remarkable physicochemical properties and excellent biocompatibility. Nanomaterials have been developed for virus detection and tracking and for antiviral strategies, to better understand viruses and reduce viral infections, implying a bright future for this field. Herein, the recent advances are systematically summarized regarding the nanomaterials used in viral studies. Representative applications of nanomaterials to viral detection and tracking are described. The antiviral effects achieved with nanomaterials based on different mechanisms are also described, including entry inhibition, inhibition of viral replication, and immunological enhancement. The current challenges and future opportunities in this promising field are also discussed.

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“…3.5 nm) organized on the surface of larger layered double hydroxide (LDH) NPs such as MgLDH, ZnLDH, and MgFeLDH (approx. 150 nm) using HBV as a model virus and hepatoma-derived HepG2.2.215 cells for viral replication reduced the amount of viral and subviral particles released from treated cells by up to 80%; in the presence of AuNPs/LDHs the HBV particles were sequestered within the treated cells and the highest antiviral HBV response (>90% inhibition of HBV secretion) was estimated with AuNPs/MgFeLDH (Carja et al 2015). Cu 2 O NPs that were tested on antiviral activity against HCV pronouncedly inhibited the infectivity of HCVcc/Huh7.5.1 at a noncytotoxic concentration, they inhibited the entry of HCV pseudoparticles (HCVpp), including genotypes 1a, 1b, and 2a, while no effect on HCV replication was observed and they were found to stop HCV infection both at the attachment and entry stages suggesting that Cu 2 O NPs could be used in the treatment of patients with chronic hepatitis C (Hang et al 2015).…”

Section: Hepatitis B and C Virusesmentioning

confidence: 99%

Nanoformulations: A Valuable Tool in the Therapy of Viral Diseases Attacking Humans and Animals

Jampílek

Kráľová

2019

Nanotheranostics

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Various viruses can be considered as one of the most frequent causes of human diseases, from mild illnesses to really serious sicknesses that end fatally. Numerous viruses are also pathogenic to animals and plants, and many of them, mutating, become pathogenic also to humans. Several cases of affecting humans by originally animal viruses have been confirmed. Viral infections cause significant morbidity and mortality in humans, the increase of which is caused by general immunosuppression of the world population, changes in climate, and overall globalization. In spite of the fact that the pharmaceutical industry pays great attention to human viral infections, many of clinically used antivirals demonstrate also increased toxicity against human cells, limited bioavailability, and thus, not entirely suitable therapeutic profile. In addition, due to resistance, a combination of antivirals is needed for life-threatening infections. Thus, the development of new antiviral agents is of great importance for the control of virus spread. On the other hand, the discovery and development of structurally new antivirals represent risks. Therefore, another strategy is being developed, namely the reformulation of existing antivirals into nanoformulations and investigation of various metal and metalloid nanoparticles with respect to their diagnostic, prophylactic, and therapeutic antiviral applications. This chapter is focused on nanoscale materials/formulations with the potential to be used for the treatment or inhibition of the spread of viral diseases caused by human immunodeficiency virus, influenza A viruses (subtypes H3N2 and H1N1), avian influenza and swine influenza viruses, respiratory syncytial virus, herpes simplex virus, hepatitis B and C viruses, Ebola and Marburg viruses, Newcastle disease virus, dengue and Zika viruses, and pseudorabies virus. Effective antiviral long-lasting and target-selective nanoformulations developed for oral, intravenous, intramuscular, intranasal, intrarectal, intravaginal, and intradermal applications are discussed.

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Self-assemblies of plasmonic gold/layered double hydroxides with highly efficient antiviral effect against the hepatitis B virus

Cited by 29 publications

References 45 publications

Nanotechnology for virus treatment

Nanotechnology for virus treatment

Recent Progress on Biomaterials Fighting against Viruses

Nanoformulations: A Valuable Tool in the Therapy of Viral Diseases Attacking Humans and Animals

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