Self-assembling peptide nanofiber scaffold promotes the reconstruction of acutely injured brain

Guo, Jiasong; Leung, Gilberto Ka Kit; Su, Huanxing; Yuan, Qiuju; Wang, Li; Chu, Tak‐Ho; Zhang, Wenming; Pu, Jenny Kan Suen; Ng, Gloria Kowk Po; Wong, Wai Man; Dai, Xiujuan J.; Wu, Wutian

doi:10.1016/j.nano.2008.12.001

Cited by 152 publications

(94 citation statements)

References 23 publications

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“…An important observation was that if the hydrogel did not contain culture media, cavities and cysts formed around the implant due to its low pH, a consequence of the mechanisms used to trigger the assembly process. Scaffolds based on the RADA16-1 peptide have also been implanted into the injured cortex of adult rats where regeneration was also observed [62]. This was evident by the absence of cavities after 6 weeks, in addition to a reduction in recruited microglia/macrophages and astrocytosis compared to the sham (Fig.…”

Section: Neural Applicationsmentioning

confidence: 93%

Self-Assembled Peptides: Characterisation and In Vivo Response

Nisbet

Williams

2012

Biointerphases

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The fabrication of tissue engineering scaffolds is a well-established field that has gained recent prominence for the in vivo repair of a variety of tissue types. Recently, increasing levels of sophistication have been engineered into adjuvant scaffolds facilitating the concomitant presentation of a variety of stimuli (both physical and biochemical) to create a range of favourable cellular microenvironments. It is here that self-assembling peptide scaffolds have shown considerable promise as functional biomaterials, as they are not only formed from peptides that are physiologically relevant, but through molecular recognition can offer synergy between the presentation of biochemical and physio-chemical cues. This is achieved through the utilisation of a unique, highly ordered, nano- to microscale 3-D morphology to deliver mechanical and topographical properties to improve, augment or replace physiological function. Here, we will review the structures and forces underpinning the formation of self-assembling scaffolds, and their application in vivo for a variety of tissue types.

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Section: Neural Applicationsmentioning

confidence: 93%

Self-Assembled Peptides: Characterisation and In Vivo Response

Nisbet

Williams

2012

Biointerphases

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“…Peptide amphiphiles that self-assemble into nanofibers have successfully been used for neural differentiation in vitro and for in vivo bridging of CNS tissue defects in several studies (Mammadov et al, 2012a,b;Silva et al, 2004;Tysseling et al, 2010;Tysseling-Mattiace et al, 2008). Self-assembled peptide nanofibers produced from alternating basic, hydrophobic, and acidic amino acids (RADA16) have also been shown to enhance neural cell culture and provide therapeutic effects in several CNS dysfunctions (EllisBehnke et al, 2006;Gelain et al, 2011;Guo et al, 2009;Holmes et al, 2000;Silva, 2005). Composites of peptides and nanofibers are very promising scaffold materials for neural growth and regeneration.…”

Section: Self-assembling Materialsmentioning

confidence: 99%

Neural ECM mimetics

Estrada

Tekinay

Müller

2014

Progress in Brain Research

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The consequence of numerous neurological disorders is the significant loss of neural cells, which further results in multilevel dysfunction or severe functional deficits. The extracellular matrix (ECM) is of tremendous importance for neural regeneration mediating ambivalent functions: ECM serves as a growth-promoting substrate for neurons but, on the other hand, is a major constituent of the inhibitory scar, which results from traumatic injuries of the central nervous system. Therefore, cell and tissue replacement strategies on the basis of ECM mimetics are very promising therapeutic interventions. Numerous synthetic and natural materials have proven effective both in vitro and in vivo. The closer a material's physicochemical and molecular properties are to the original extracellular matrix, the more promising its effectiveness may be. Relevant factors that need to be taken into account when designing such materials for neural repair relate to receptor-mediated cell-matrix interactions, which are dependent on chemical and mechanical sensing. This chapter outlines important characteristics of natural and synthetic ECM materials (scaffolds) and provides an overview of recent advances in design and application of ECM materials for neural regeneration, both in therapeutic applications and in basic biological research.

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“…The gap was reduced in all peptide-treated animals within the first 24 h. Compared with saline, peptide scaffold appeared to create a seamless junction to knit the tissue together across the lesion site which led to axonal growth, partially functional restoring the optic tract and the return of functional vision. Guo et al further applied RADA peptide to reconstruct cerebral parenchyma in a rat TBI model [104]. Histological, immunohistochemical and apoptosis studies were performed at 2 d, 2 weeks, and 6 weeks after surgery.…”

Section: Traditional Nanofiber Biomaterials For Cnsmentioning

confidence: 99%

Self-assembling peptide nanofiber hydrogels for central nervous system regeneration

Liu

Wang

et al. 2014

Front. Mater. Sci.

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Central nervous system (CNS) presents a complex regeneration problem due to the inability of central neurons to regenerate correct axonal and dendritic connections. However, recent advances in developmental neurobiology, cell signaling, cell-matrix interaction, and biomaterials technologies have forced a reconsideration of CNS regeneration potentials from the viewpoint of tissue engineering and regenerative medicine. The applications of a novel tissue regeneration-inducing biomaterial and stem cells are thought to be critical for the mission. The use of peptide nanofiber hydrogels in cell therapy and tissue engineering offers promising perspectives for CNS regeneration. Self-assembling peptide undergo a rapid transformation from liquid to gel upon addition of counterions or pH adjustment, directly integrating with the host tissue. The peptide nanofiber hydrogels have mechanical properties that closely match the native central nervous extracellular matrix, which could enhance axonal growth. Such materials can provide an optimal three dimensional microenvironment for encapsulated cells. These materials can also be tailored with bioactive motifs to modulate the wound environment and enhance regeneration. This review intends to detail the recent status of selfassembling peptide nanofiber hydrogels for CNS regeneration.

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Self-assembling peptide nanofiber scaffold promotes the reconstruction of acutely injured brain

Cited by 152 publications

References 23 publications

Self-Assembled Peptides: Characterisation and In Vivo Response

Self-Assembled Peptides: Characterisation and In Vivo Response

Neural ECM mimetics

Self-assembling peptide nanofiber hydrogels for central nervous system regeneration

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