Self-assembling tripeptide based hydrogels and their use in removal of dyes from waste-water

Adhikari, Bimalendu; Palui, Goutam; Banerjee, Arindam

doi:10.1039/b905985g

Cited by 248 publications

(174 citation statements)

References 84 publications

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“…This observation indicates that all N−H and >CO are hydrogen bonded in the assembled gel state (in both xerogel and wet gel) and suggests that a β-sheet conformation is present in the assembled gel state. 40,48 Moreover, weak bands at 1689 and at 1688 cm −1 were observed in the xerogel and wet gel states, respectively. This suggests the presence of an antiparallel β-sheet arrangement in the gel state.…”

Section: ■ Results and Discussionmentioning

confidence: 97%

Formation of Hybrid Hydrogels Consisting of Tripeptide and Different Silver Nanoparticle-Capped Ligands: Modulation of the Mechanical Strength of Gel Phase Materials

et al. 2012

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An N-terminally Boc (tert-butyloxycarbonyl) group-protected synthetic tripeptide (Boc-Phe-Phe-Ala-OH) has been found to form a translucent hydrogel in basic aqueous medium. This hydrogel material has been characterized using field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), Fourier transformed infrared spectroscopy, differential scanning calorimetric, X-ray diffraction (XRD), and rheological studies. FE-SEM and TEM studies have revealed the formation of a nanofibrillar network structure upon gelation. Thiol (-SH) containing ligands (amino acid/peptide) have been used to stabilize small silver nanoparticles (AgNPs), and these thiol-capped silver nanoparticles have been incorporated into this hydrogel to prepare hybrid hydrogels. Morphological study of silver nanoparticles containing a hybrid hydrogel (using TEM experiments) has indicated the nice fabrication of AgNPs along the gel nanofibers. Fabrication of nanoparticles upon the gel nanofibers is due to noncovalent interactions between the capping ligands of the nanoparticles and the peptide-based hydrogel nanofibers. Rheological investigations of these hybrid hydrogels have shown the weakening of the mechanical strength of the hydrogel after incorporation of AgNPs within the native hydrogel system. Our studies have vividly shown the dependence of the elastic modulus (G') and yield stress (σ(y)) on three factors: (a) the nature of the stabilizing ligands used for AgNPs, (b) the size of the AgNPs, and (c) the amount of AgNPs used for the preparation of hybrid hydrogel systems. Modulation of the mechanical strength of the hybrid hydrogel can be successfully achieved by varying these above-mentioned factors. This modulation of the mechanical properties keeps a future promise to make tunable soft materials with interesting properties.

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Section: ■ Results and Discussionmentioning

confidence: 97%

Formation of Hybrid Hydrogels Consisting of Tripeptide and Different Silver Nanoparticle-Capped Ligands: Modulation of the Mechanical Strength of Gel Phase Materials

et al. 2012

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“…5À15 They have shown promising potential applications in controlled drug delivery, 16À19 environmental protection, 20 tissue engineering, 21À23 etc. For the application of small molecular hydrogels in tissue engineering, especially in cell culture, peptide-based small molecular hydrogels have been widely investigated and demonstrated suitable for culture of different cells by several groups.…”

Section: ' Introductionmentioning

confidence: 99%

Responsive Small Molecular Hydrogels Based on Adamantane–Peptides for Cell Culture

Yang

Li²,

Liu³

et al. 2011

J. Phys. Chem. B

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The development of responsive small molecular hydrogels that can be applied for recovery of cells postculture attract extensive interests for researchers in fields of cell biology, stem cell differentiation, and tissue engineering. We report in this study several responsive small molecular hydrogels based on adamantane-peptides whose gel to clear solution phase transition can be achieved by addition of β-cyclodextrin (β-CD) derivatives. The small molecular hydrogels are formed by our recently developed method of disulfide bond cleavage by glutathione (GSH). Mouse fibroblast 3T3 cells attach and grow well at the surface of hydrogels. Furthermore, 3T3 cells postculture can be recovered from the gels by the addition of a β-CD derivative due to formation of clear solutions by the adamantane-β-CD interaction. The culture on hydrogels and recovery process do not cause obvious effects on behaviors of 3T3 cells. The results shown in this study indicate that small molecular hydrogels based on adamantane-peptides have great potentials in research fields where further analysis of cells is needed.

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“…Peptides of Nap-GFFYG (VPGAG) 1 (1) and Nap-GFFYG (VPGAG) 2 (2) were prepared by the standard Fmocsolid phase peptide synthesis (SPPS) using 2-chlorotrityl chloride resin. Rheology test was done on an AR 2000ex (TA instrument) system, 40 mm parallel plates were used during the experiment at the gap of 500 µm.…”

Section: General Proceduresmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10] Unlike the polymeric hydrogels that are formed by the cross-linking of polymer chains, supramolecular hydrogels are formed by non-covalent bonds such as π-π interactions, hydrogen bonds, hydrophobic interactions, and charge interactions. [11][12][13][14][15][16][17][18][19] Therefore, supramolecular hydrogels are thought to be biocompatible and easily degraded in biological environments.…”

Section: Introductionmentioning

confidence: 99%

A Supramolecular Hydrogel Inspired by Elastin

Ding

Wang

et al. 2011

Chin. J. Chem.

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Self-assembly prevails in nature and learning from nature will lead to biofunctional materials. Inspired by the protein of elastin, we reported in this study on a supramolecular hydrogel bearing the elastin repeating peptide of VPGAG. The visco-elasticity property, morphology of the nanostructures, and aromatic stacking in the self-assembled nanostructure were characterized by a rheometry, transmission electron microscope (TEM), and fluorescence microscope, respectively. The biocompatibility of the gelator was also proved by an MTT assay. Though the supramolecular hydrogel failed to exhibit a high elasticity like elastin, the thixotropic hydrogel might have potentials for the applications in fields of cell culture, controlled-drug release, etc.

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Self-assembling tripeptide based hydrogels and their use in removal of dyes from waste-water

Cited by 248 publications

References 84 publications

Formation of Hybrid Hydrogels Consisting of Tripeptide and Different Silver Nanoparticle-Capped Ligands: Modulation of the Mechanical Strength of Gel Phase Materials

Formation of Hybrid Hydrogels Consisting of Tripeptide and Different Silver Nanoparticle-Capped Ligands: Modulation of the Mechanical Strength of Gel Phase Materials

Responsive Small Molecular Hydrogels Based on Adamantane–Peptides for Cell Culture

A Supramolecular Hydrogel Inspired by Elastin

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