In the context of increasingly complex living environments, it is crucial to develop smart indoor wall materials for resisting external interference such as humidity changes. Herein, we report a facile and scalable strategy to prepare advanced polyurethane (PU) foam as a multifunctional indoor wall, integrating solar-driven humidity regulation, noise absorption, and flame retardancy. Benefiting from the in situ synthesis technology to maintain the original metal−organic framework (MOF) porosity (0.149 cm 3 /g) and realize a high MOF loading (63.72%), the advanced PU-based module showed excellent water collection abilities and fast water transport kinetics. As a proof-of-concept demonstration, the designed PU-based regulation system provided a comfortable humidity environment (40−70% RH) of a simulated room in outdoor experiments, dependent on the automatic water collection of the Al-fumarate backbone at night as well as the continuous water evaporation promoted by the photothermal layer during daytime. Therefore, the developed multifunctional PU-based management module has great potential for constructing modern, comfortable, and energy-efficient indoor environments.