Self-Assembly of Asymmetrically Functionalized Titania Nanoparticles into Nanoshells

Svensson, Fredric G.; Seisenbaeva, Gulaim A.; Kotov, Nicholas A.; Kessler, Vadim G.

doi:10.3390/ma13214856

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…The self-assembly approach is widely used for the competitive surface assimilation of incompatible ligands, such as hydrophobic and hydrophilic ligands, on particle surfaces and for block copolymer formation, including di- and tri-block copolymers as summarized in Figure 7 [ 56 , 57 , 58 ]. Gold nanocrystals with their thiol-binding affinity are widely used to perform competitive adsorption of incompatible ligands onto particles via self-assembly [ 59 ].…”

Section: Fabrication Of Janus Particlesmentioning

confidence: 99%

Development of Janus Particles as Potential Drug Delivery Systems for Diabetes Treatment and Antimicrobial Applications

Tan¹,

Danquah

Jeevanandam

et al. 2023

Pharmaceutics

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Janus particles have emerged as a novel and smart material that could improve pharmaceutical formulation, drug delivery, and theranostics. Janus particles have two distinct compartments that differ in functionality, physicochemical properties, and morphological characteristics, among other conventional particles. Recently, Janus particles have attracted considerable attention as effective particulate drug delivery systems as they can accommodate two opposing pharmaceutical agents that can be engineered at the molecular level to achieve better target affinity, lower drug dosage to achieve a therapeutic effect, and controlled drug release with improved pharmacokinetics and pharmacodynamics. This article discusses the development of Janus particles for tailored and improved delivery of pharmaceutical agents for diabetes treatment and antimicrobial applications. It provides an account of advances in the synthesis of Janus particles from various materials using different approaches. It appraises Janus particles as a promising particulate system with the potential to improve conventional delivery systems, providing a better loading capacity and targeting specificity whilst promoting multi-drugs loading and single-dose-drug administration.

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Section: Fabrication Of Janus Particlesmentioning

confidence: 99%

Development of Janus Particles as Potential Drug Delivery Systems for Diabetes Treatment and Antimicrobial Applications

Tan¹,

Danquah

Jeevanandam

et al. 2023

Pharmaceutics

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“…3 nm colloidal titania [ 33 ], (ii) ca. 10 nm hydrothermally synthesized titania [ 34 ], and (iii) molecular ammonium oxo-lactato titanate as sources [ 35 ] of titania dispersed in cellulose nanofibrils.…”

Section: Introductionmentioning

confidence: 99%

Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials

et al. 2021

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In order to develop a new type of improved wound dressing, we combined the wound healing properties of nanotitania with the advantageous dressing properties of nanocellulose to create three different hybrid materials. The hemocompatibility of the synthesized hybrid materials was evaluated in an in vitro human whole blood model. To our knowledge, this is the first study of the molecular interaction between hybrid nanotitania and blood proteins. Two of the hybrid materials prepared with 3 nm colloidal titania and 10 nm hydrothermally synthesized titania induced strong coagulation and platelet activation but negligible complement activation. Hence, they have great potential as a new dressing for promoting wound healing. Unlike the other two, the third hybrid material using molecular ammonium oxo-lactato titanate as a titania source inhibited platelet consumption, TAT generation, and complement activation, apparently via lowered pH at the surface interface. It is therefore suitable for applications where a passivating surface is desired, such as drug delivery systems and extracorporeal circuits. This opens the possibility for a tailored blood response through the surface functionalization of titania.

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“…Svensson et al in their communication, reported a proof of principle for the self-assembly of titania nanoshells from anisotropically functionalized titania NPs successfully utilized for fast-release drug delivery application [ 12 ].…”

mentioning

confidence: 99%

Special Issue “Metal and Metal Oxide Nanoparticles: Design, Characterization, and Biomedical Applications”

Limongi¹

2021

Materials

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Self-Assembly of Asymmetrically Functionalized Titania Nanoparticles into Nanoshells

Cited by 4 publications

References 38 publications

Development of Janus Particles as Potential Drug Delivery Systems for Diabetes Treatment and Antimicrobial Applications

Development of Janus Particles as Potential Drug Delivery Systems for Diabetes Treatment and Antimicrobial Applications

Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials

Special Issue “Metal and Metal Oxide Nanoparticles: Design, Characterization, and Biomedical Applications”

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