Self‐Assembly of Nucleobase, Nucleoside and Nucleotide Coordination Polymers: From Synthesis to Applications

Lopez, Anand; Liu, Juewen

doi:10.1002/cnma.201700154

Cited by 59 publications

(30 citation statements)

References 123 publications

(254 reference statements)

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“…This is understandable because the phosphate backbone of DNA can interact with Ln 3+ . 27,40 We calculated the percentage of released DNA, and the Tb 3+ /GMP sample released around 4-fold more DNA than Tb 3+ /AMP, suggesting that the DNA adsorption affinity on Tb 3+ /AMP was higher.…”

Section: Resultsmentioning

confidence: 99%

Continuously Tunable Nucleotide/Lanthanide Coordination Nanoparticles for DNA Adsorption and Sensing

Zhang

Liu

et al. 2018

ACS Omega

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Metal–organic coordination polymers (CPs) have attracted great research interest because they are easy to prepare, porous, flexible in composition, and designable in structure. Their applications in biosensor development, drug delivery, and catalysis have been explored. Lanthanides and nucleotides can form interesting CPs, although most previous works have focused on a single type of metal ligand. In this work, we explored mixed nucleotides and studied their DNA adsorption properties using fluorescently labeled oligonucleotides. Adenosine monophosphate (AMP) and guanosine monophosphate (GMP) formed negatively charged CP nanoparticles with most lanthanides, and thus a salt was required to adsorb negatively charged DNA. DNA adsorption was faster and reached a higher capacity with lighter lanthanides. Desorption of pre-adsorbed DNA by inorganic phosphates, urea, proteins, surfactants, and competing DNA was successively carried out. The results suggested the importance of the DNA phosphate backbone, although hydrogen bonding and DNA bases also contributed to adsorption. The AMP CPs adsorbed DNA more strongly than the GMP ones, and using mixtures of AMP and GMP, continuous tuning of DNA adsorption affinity was achieved. Such CPs were also used as a sensor for DNA detection based on the different affinities of single- and double-stranded DNA, and a detection limit of 0.9 nM target DNA was achieved. Instead of tuning DNA adsorption by varying the length and sequence of DNA, the composition of CPs can also be controlled to achieve this goal.

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Section: Resultsmentioning

confidence: 99%

Continuously Tunable Nucleotide/Lanthanide Coordination Nanoparticles for DNA Adsorption and Sensing

Zhang

Liu

et al. 2018

ACS Omega

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“…61,62 It has been recently demonstrated that AMP-based hydrogels can be generated through coordination of this nucleotide with Zn 2+ ions. 63,64 Capitalizing on the The hydrogels were seen to form in the whole range of graphene concentrations tested, i.e., between ~0.01 and 0.8 mg mL -1 , even though at the highest concentration the total weight of flakes incorporated in the gel was similar to that of the Zn 2+ -AMP component (i.e., ~1.2-1.3 mg for a single centrifuge tube). On the micrometric scale, the graphenefree hydrogel exhibited a homogeneous appearance, as exemplified in the STEM image of Fig.…”

Section: Graphene-nucleotide Hybrid Hydrogels and Their Uptake/releasmentioning

confidence: 99%

A biosupramolecular approach to graphene: Complementary nucleotide-nucleobase combinations as enhanced stabilizers towards aqueous-phase exfoliation and functional graphene-nucleotide hydrogels

Caridad

Paredes

Pérez–Vidal

et al. 2018

Carbon

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The ability to use RNA/DNA nucleotides as colloidal stabilizers for graphene would be an important asset, as a close graphene-nucleotide association would facilitate access to hybrid systems where the rich covalent and supramolecular chemistry of these biomolecules could be exploited alongside graphene in a number of applications. Unfortunately, single RNA/DNA nucleotides are inefficient graphene dispersants. Here we propose and demonstrate a supramolecular strategy which overcomes this limitation, affording aqueous dispersions of high quality graphene flakes with much improved colloidal stability. A nucleotide is combined with its complementary nucleobase yielding stable hydrogen-bonded supramolecular entities that adsorb more strongly on the graphene surface than their individual components. Based on this approach, graphene-nucleotide hybrid hydrogels could be readily obtained, where the graphene flakes were intimately and uniformly intermixed with the nucleotide-based gel phase. Such hydrogels exhibited higher uptakes and/or slower release profiles of dyes and drugs (rhodamine B, methylene blue and tetracycline) than their graphene-free counterparts. Cell proliferation tests suggested the graphene materials obtained with nucleotide-nucleobase stabilizers to be biocompatible. The present results constitute a novel strategy in the processing and molecular integration of graphene that could be extended to other (bio)molecules of interest towards the realization of functional materials for different applications.

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“…Moreover, the use of organic and natural building blocks makes these materials highly suitable for green and bio-compatible applications (Zhang 2003; Lihi Adler-Abramovich and Gazit 2014). For instance, the use of nucleobases and nucleobases-containing molecules as supramolecular motifs is well established (Sivakova and Rowan 2005; Lopez and Liu 2017). Although most of the examples involve the assembly of modified nucleobases or the use of coordination chemistry, there are a few examples that demonstrate the intrinsic ability of nucleobases to self-assemble into entities with unique properties.…”

Section: Self-assembly Of Metabolites In Materials Sciencementioning

confidence: 99%

Functional metabolite assemblies—a review

et al. 2018

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Metabolites are essential for the normal operation of cells and fulfill various physiological functions. It was recently found that in several metabolic disorders, the associated metabolites could self-assemble to generate amyloid-like structures, similar to canonical protein amyloids that have a role in neurodegenerative disorders. Yet, assemblies with typical amyloid characteristics are also known to have physiological function. In addition, many non-natural proteins and peptides presenting amyloidal properties have been used for the fabrication of functional nanomaterials. Similarly, functional metabolite assemblies are also found in nature, demonstrating various physiological roles. A notable example is the structural color formed by guanine crystals or fluorescent crystals in feline eyes responsible for enhanced night vision. Moreover, some metabolites have been used for the in vitro fabrication of functional materials, such as glycine crystals presenting remarkable piezoelectric properties or indigo films used to assemble organic semiconductive electronic devices. Therefore, we believe that the study of metabolite assemblies is not only important in order to understand their role in normal physiology and in pathology, but also paves a new route in exploring the fabrication of organic, bio-compatible materials.

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Self‐Assembly of Nucleobase, Nucleoside and Nucleotide Coordination Polymers: From Synthesis to Applications

Cited by 59 publications

References 123 publications

Continuously Tunable Nucleotide/Lanthanide Coordination Nanoparticles for DNA Adsorption and Sensing

Continuously Tunable Nucleotide/Lanthanide Coordination Nanoparticles for DNA Adsorption and Sensing

A biosupramolecular approach to graphene: Complementary nucleotide-nucleobase combinations as enhanced stabilizers towards aqueous-phase exfoliation and functional graphene-nucleotide hydrogels

Functional metabolite assemblies—a review

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