Self-assembly of pH-responsive dextran-g-poly(lactide-co-glycolide)-g-histidine copolymer micelles for intracellular delivery of paclitaxel and its antitumor activity

Zhang, Jiulong; Chen, Kang; Ding, Ying; Xin, Xiu; Li, Wenpan; Zhang, Mengjun; Hu, Haiyang; Qiao, Mingxi; Chen, Dawei

doi:10.1039/c5ra22463b

Cited by 21 publications

(12 citation statements)

References 41 publications

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“…Established by now main methods for dextran nanoparticle preparation include: the cross‐linking in reverse micelle (water–paraffin emulsion), however, in this case the particle sizes are difficult to control; the dextran oxidation, the multistage formation, and purification of dextran nanoparticles being the main disadvantage of this method; the self‐assembly of copolymers and conjugates based on dextran. This approach suggests the complicated synthetic procedures of dextran modification . Moreover, the absence of cross‐linking in the assemblies obtained may lead to the destruction of dextran associate and change of their structure in biological media …”

Section: Introductionmentioning

confidence: 99%

Dextran Nanoparticles Cross‐Linked in Aqueous and Aqueous/Alcoholic Media

Iakobson

Добродумов

Saprykina

et al. 2017

Macro Chemistry & Physics

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The attractiveness of the dextran nanoparticle application in medicine and pharmacology results from biocompatibility, biodegradability, and nontoxicity of the polymer. However, it still remains a challenge to prepare such nanoparticles in an aqueous medium due to dextran hydrophilicity. Here, the technique of dextran nanoparticle synthesis with the average diameter of 140–450 nm in aqueous and aqueous/ethanolic media is described. The chemical structure of cross‐linker used for the dextran nanoparticle stabilization is demonstrated to influence the dextran nanoparticle diameter, size distribution, and ζ‐potential. As shown the regulation of the nanoparticle diameter and ζ‐potential is possible through the surfactants and/or dextran nonsolvent (ethanol) addition into the reaction medium. Due to the additional steric stabilization, the dextran nanoparticles of minimum diameter are formed in the presence of ionic surfactants in the aqueous/ethanolic medium. The nanoparticle shape and diameter are analyzed by dynamic light scattering, transmission electron microscopy, and scanning electron microscopy; the composition is investigated by 1H NMR spectroscopy.

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Section: Introductionmentioning

confidence: 99%

Dextran Nanoparticles Cross‐Linked in Aqueous and Aqueous/Alcoholic Media

Iakobson

Добродумов

Saprykina

et al. 2017

Macro Chemistry & Physics

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“…Besides this, HA has been widely used for the construction of tumor-targeting nanoparticles because it could specifically target CD44 receptors of tumor cells and facilitate cellular uptake (Huo et al, 2017 ; Cai et al, 2019 ; Zhang et al, 2020 ; Rangasami et al, 2021 ). The copolymer micelle is an amphiphilic molecule, which could self-assembly into a nanoparticle in aqueous solution (Zhang et al, 2016 , 2017 ). Structure-modified HA with hydrophobic molecules could form grafted amphiphilic copolymers and be used for micelle construction.…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Hyaluronic Acid-Based Copolymer-Mixed Micelle in Combination PD-L1 Immune Checkpoint Blockade for Enhanced Chemo-Immunotherapy of Melanoma

Zhou

Dong

Song

et al. 2021

Front. Bioeng. Biotechnol.

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The application of combinational therapy breaks the limitation of monotherapy and achieves better clinical benefit for tumor therapy. Herein, a hyaluronic acid/Pluronic F68-based copolymer-mixed micelle was constructed for targeted delivery of chemotherapeutical agent docetaxel (PHDM) in combination with programmed cell death ligand-1(PD-L1) antibody. When PHDM+anti-PDL1 was injected into the blood system, PHDM could accumulate into tumor sites and target tumor cells via CD44-mediated endocytosis and possess tumor chemotherapy. While anti-PDL1 could target PD-L1 protein expressed on surface of tumor cells to the immune checkpoint blockade characteristic for tumor immunotherapy. This strategy could not only directly kill tumor cells but also improve CD8+ T cell level and facilitate effector cytokines release. In conclusion, the rational-designed PHDM+anti-PDL1 therapy strategy creates a new way for tumor immune-chemotherapy.

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“…7 However, it has been reported that the extracellular pH of solid tumors is more acidic than normal tissues. 8,9 Choosing a pH-sensitive drug delivery system is one of the ideal options for adding specific tissue distribution undergoing chemotherapy, as it could increase the therapeutical efficacy and reduce adverse effects. Therefore, it is necessary for researchers to find a multifunction carrier for efficient drug delivery to the tumor regions.…”

Section: Introductionmentioning

confidence: 99%

<p>Doxorubicin-Loaded Carbon Dots Lipid-Coated Calcium Phosphate Nanoparticles for Visual Targeted Delivery and Therapy of Tumor</p>

Zhang¹,

Zhang²,

Jiang³

et al. 2020

IJN

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Background: Carbon dots (CDs) have attracted extensive attention in recent years because of their high biocompatibility and unique optical property. But they could not be well applied in the drug delivery system to enable distribution in tumor sites with their low pH sensitivity. They are barriers for drug delivery. CDs as an imaging proper were conjugated with doxorubicin (DOX) lipid-coated calcium phosphate (LCP) nanoparticle, for a pH-sensitive nanocarrier and delivery of the antitumor drugs. Materials and Methods: CDs were prepared by one-step hydrothermal treatment of citric acid and ethylenediamine. The nanoparticles were simply prepared by using microemulsion technology to form calcium phosphate (CaP) core and further coated with cationic lipids. Results: The structure was characterized by FTIR, XRD and TEM. In vitro release study revealed that DOX-CDs@LCP was pH dependent. The cytotoxicity assay demonstrated that it exhibited enhanced efficiency compared to the control group (DOX-CDs), but weaker than free DOX. The cellular uptake revealed that these pH-sensitive nanoparticles could be taken up effectively and deliver DOX into the cytoplasm to reach antitumor effect. The fluorescence imaging indicated that DOX-CDs@LCP mostly distributed in the tumor region due to the enhanced permeability and retention effect (EPR) to reduce its systematical toxicity. Importantly, an antitumor activity study demonstrated that the DOX-CDs@LCP nanoparticles had higher antitumor activity than any other groups and lower toxicity. The results showed that LCP could significantly promote the release in tumor microenvironment due to pH-response. The DOX-CDs could enhance load capacity and reduce drug premature releasing; real-time tracking of efficacy as confocal imaging contrast agent. Thus, DOX-CDs@LCP had antitumor capacity and lower systematic toxicity in tumor therapy. Conclusion: DOX-CDs@LCP were proven as a promising tumor pH-sensitive and imaging-guided drug delivery system for liver cancer chemotherapy.

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Self-assembly of pH-responsive dextran-g-poly(lactide-co-glycolide)-g-histidine copolymer micelles for intracellular delivery of paclitaxel and its antitumor activity

Abstract: Herein, dextran (DX) was conjugated with poly(lactide-co-glycolide) (PLGA) and histidine (His) to prepare a pH-responsive nanocarrier, dextran-g-poly(lactide-co-glycolide)-g-histidine (HDP) micelles, for the delivery of antitumor drugs.

Cited by 21 publications

References 41 publications

Dextran Nanoparticles Cross‐Linked in Aqueous and Aqueous/Alcoholic Media

Dextran Nanoparticles Cross‐Linked in Aqueous and Aqueous/Alcoholic Media

Rational Design of Hyaluronic Acid-Based Copolymer-Mixed Micelle in Combination PD-L1 Immune Checkpoint Blockade for Enhanced Chemo-Immunotherapy of Melanoma

<p>Doxorubicin-Loaded Carbon Dots Lipid-Coated Calcium Phosphate Nanoparticles for Visual Targeted Delivery and Therapy of Tumor</p>

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