Self-assembly of trigonal building blocks into nanostructures: molecular design and biomedical applications

Long, Kaiqi; Liu, Yuwei; Li, Yafei; Wang, Weiping

doi:10.1039/d0tb01128b

Cited by 21 publications

(23 citation statements)

References 114 publications

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Section: Self-assembly Biomaterials For Neural Repairmentioning

confidence: 99%

“… 207 , 208 Similarly, the redox reaction triggered by electrical stimulation of polydopamine (PDA) coatings have been shown to promote cell spreading, proliferation, and differentiation on a titanium electrode. 209 This class of materials termed “switchable” can be used to implement highly controllable electrically mediated therapies, allowing for temporal and spatial control of bioactive, topographical, electrochemical, and structural cues to neural cells. Although the properties mentioned are representative of the wide range of possibilities offered by switchable materials, today they only serve as a proof of concept toward an innovative vision for SAP materials.…”

Section: Considerations For Electrical Stimulationmentioning

confidence: 99%

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Self-Assembling Hydrogel Structures for Neural Tissue Repair

Peressotti

Koehl

Goding

et al. 2021

ACS Biomater. Sci. Eng.

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Hydrogel materials have been employed as biological scaffolds for tissue regeneration across a wide range of applications. Their versatility and biomimetic properties make them an optimal choice for treating the complex and delicate milieu of neural tissue damage. Aside from finely tailored hydrogel properties, which aim to mimic healthy physiological tissue, a minimally invasive delivery method is essential to prevent off-target and surgery-related complications. The specific class of injectable hydrogels termed self-assembling peptides (SAPs), provide an ideal combination of in situ polymerization combined with versatility for biofunctionlization, tunable physicochemical properties, and high cytocompatibility. This review identifies design criteria for neural scaffolds based upon key cellular interactions with the neural extracellular matrix (ECM), with emphasis on aspects that are reproducible in a biomaterial environment. Examples of the most recent SAPs and modification methods are presented, with a focus on biological, mechanical, and topographical cues. Furthermore, SAP electrical properties and methods to provide appropriate electrical and electrochemical cues are widely discussed, in light of the endogenous electrical activity of neural tissue as well as the clinical effectiveness of stimulation treatments. Recent applications of SAP materials in neural repair and electrical stimulation therapies are highlighted, identifying research gaps in the field of hydrogels for neural regeneration.

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Section: Self-assembly Biomaterials For Neural Repairmentioning

confidence: 99%

Section: Considerations For Electrical Stimulationmentioning

confidence: 99%

Self-Assembling Hydrogel Structures for Neural Tissue Repair

Peressotti

Koehl

Goding

et al. 2021

ACS Biomater. Sci. Eng.

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“…As previously reported, the trigonal structure would be necessary for the self‐assembly of trigonal molecules. [ 22 ] Thus, DTNPs would be destabilized following the photocleavage of DTAEA upon light irradiation. The size change of the nanoparticles upon light irradiation was also monitored by DLS (Figure S8 , Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

“…The trigonal structure of the molecules significantly promoted their self‐assembly to form nanoparticles, thereby improving the stability and modulating the in vivo fate of nanoassemblies. [ 22 ] This study provides a strategy to design simple photoresponsive nanocarriers for controlled drug release.…”

Section: Discussionmentioning

confidence: 99%

“…[ 21 ] The distinctive clathrin‐like trigonal molecules can spontaneously co‐assemble with hydrophobic drugs in aqueous solutions via flash nanoprecipitation to form stable nanoparticles. [ 22 , 23 , 24 ] The nanoparticles are able to release the encapsulated doxorubicin (DOX) upon the light irradiation. The release of DOX from the nanoparticles can be real‐time monitored based on the fluorescence resonance energy transfer (FRET) effect.…”

Section: Introductionmentioning

confidence: 99%

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Green Light‐Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma

Long

Yang

et al. 2021

Advanced Science

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Retinoblastoma is one of the most severe ocular diseases, of which current chemotherapy is limited to the repetitive intravitreal injections of chemotherapeutics. Systemic drug administration is a less invasive route; however, it is also less efficient for ocular drug delivery because of the existence of blood-retinal barrier and systemic side effects. Here, a photoresponsive drug release system is reported, which is self-assembled from photocleavable trigonal small molecules, to achieve light-triggered intraocular drug accumulation. After intravenous injection of drug-loaded nanocarriers, green light can trigger the disassembly of the nanocarriers in retinal blood vessels, which leads to intraocular drug release and accumulation to suppress retinoblastoma growth. This proof-of-concept study would advance the development of light-triggered drug release systems for the intravenous treatment of eye diseases.

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H₂S‐Responsive Small‐Molecule Nanocarriers for Drug Delivery to Colorectal Tumors

Long

Yang

et al. 2022

Advanced Therapeutics

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Hydrogen sulfide (H2S), a gaseous signaling molecule, is excessively produced in disease lesions like lung tumors and colorectal tumors. H2S is used as a trigger for stimuli‐responsive drug delivery in cancer therapies, which enables controlled release of chemotherapeutics and improves their biocompatibility and efficacy. Herein, a H2S‐responsive small‐molecule nanocarrier is developed based on the self‐assembly of a trigonal molecule, tris(azido benzyl)‐tri(2‐aminoethyl) amine (ATAEA). ATAEA with three H2S‐responsive azido benzyl groups can self‐assemble into nanocarriers (ATNPs) and encapsulate hydrophobic doxorubicin (DOX) to form drug‐loaded nanoparticles (DOX/ATNPs). H2S induces the reduction of azido benzyl group and 1,6‐elimination, which results in the dissociation of the ATAEA molecules and the nanoparticles. In HCT116 colon cancer cells, efficient H2S‐responsive DOX release from DOX/ATNPs is observed. In vivo administration of DOX/ATNPs in colon tumor‐bearing mice leads to higher drug accumulation in tumors and evident tumor growth inhibition, in comparison with non‐responsive nanoparticles. This work provides a new strategy to develop H2S‐responsive drug delivery systems for precise drug delivery to H2S‐enriched disease lesions.

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Self-assembly of trigonal building blocks into nanostructures: molecular design and biomedical applications

Abstract: This review introduces trigonal building blocks and summarizes their structural characteristics, self-assembly ability and biomedical applications.

Cited by 21 publications

References 114 publications

Self-Assembling Hydrogel Structures for Neural Tissue Repair

Self-Assembling Hydrogel Structures for Neural Tissue Repair

Green Light‐Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma

H₂S‐Responsive Small‐Molecule Nanocarriers for Drug Delivery to Colorectal Tumors

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Self-assembly of trigonal building blocks into nanostructures: molecular design and biomedical applications

Abstract: This review introduces trigonal building blocks and summarizes their structural characteristics, self-assembly ability and biomedical applications.

Cited by 21 publications

References 114 publications

Self-Assembling Hydrogel Structures for Neural Tissue Repair

Self-Assembling Hydrogel Structures for Neural Tissue Repair

Green Light‐Triggered Intraocular Drug Release for Intravenous Chemotherapy of Retinoblastoma

H2S‐Responsive Small‐Molecule Nanocarriers for Drug Delivery to Colorectal Tumors

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Product

Resources

About

H₂S‐Responsive Small‐Molecule Nanocarriers for Drug Delivery to Colorectal Tumors