Self-assembly strategies of organic small-molecule photosensitizers for photodynamic therapy

Xiong, Xiaohui; Liu, Jingyuan; Wu, Lei; Xiong, Shuangyu; Jiang, Wen; Wang, Peng

doi:10.1016/j.ccr.2024.215863

Coordination Chemistry Reviews

2024

DOI: 10.1016/j.ccr.2024.215863

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Self-assembly strategies of organic small-molecule photosensitizers for photodynamic therapy

Xiaohui Xiong,

Jingyuan Liu,

Lei Wu

et al.

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Cited by 7 publications

References 173 publications

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Advancing Two‐Photon Photodynamic Therapy Over NIR‐II Excitable Conjugated Microporous Polymer with NIR‐I Emission

Li,

Yu,

et al. 2024

Adv Healthcare Materials

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The availability of second near‐infrared (NIR‐II) excitable two‐photon photosensitizers with NIR‐I emission for efficient photodynamic therapy (PDT) is limited by challenges in molecular design. In this study, a NIR‐II light‐excitable two‐photon conjugated microporous polymer (Tph‐Dbd) with emission in the NIR‐I region is developed. The large conjugated system and delocalized electronic structures endow Tph‐Dbd with a large two‐photon absorption cross‐section under NIR‐II light excitation. Moreover, the efficient electron acceptor and donor units within the π‐conjugated backbones result in NIR‐I emission for high signal‐to‐background ratio imaging, as well as separated highest occupied molecular orbital and lowest unoccupied molecular orbital distributions for excellent singlet oxygen generation ability. The excellent NIR‐II excitable two‐photon absorption activity, NIR‐I emission, good biocompatibility, and high photostability allow Tph‐Dbd to be used for efficient in vitro fluorescence imaging guided PDT. Moreover, the impressive photothermal effect of Tph‐Dbd can overcome the limitations of PDT in the treatment of hypoxic tumors. This study highlights a strategy for designing NIR‐II excitable two‐photon photosensitizers for advanced PDT.

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Advancing Two‐Photon Photodynamic Therapy Over NIR‐II Excitable Conjugated Microporous Polymer with NIR‐I Emission

Li,

Yu,

et al. 2024

Adv Healthcare Materials

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The influence of Fe2+ on the self-assembly of a bipyridine containing homopolymer: From bowl-shaped nanoparticles to vesicles

Fan,

Wang,

Sun

2024

European Polymer Journal

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Hybrid Hydrogels of Polyacrylamide and Self-assembly Photodynamic Nanoparticles with Diverse Adhesion for Infected Chronic Wound Healing

Kang,

Guo,

et al. 2024

Biomacromolecules

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The healing of infected wounds is challenging for patients. In this paper, a hybrid hydrogel with strong tissue adhesion, self-healing, and antibiosis without antibiotics was developed as a dressing to promote the healing of infected chronic wounds. Acrylamide (PAM) was polymerized with N,N-methylene bis(acrylamide) (BIS) as the substrate, and self-assembled nanoparticles of carboxymethyl chitosan and chlorin e6 (CMCS/ Ce6 NPs) trapped with magnesium (Mg 2+ ) ions were dispersed in the hydrogel substrate. CMCS/Ce6 NPs provided favorable photodynamic antibiosis via the production of reactive oxygen species (ROS) under NIR irradiation. The hybrid hydrogels exhibited excellent self-healing properties, diverse adhesion, and biocompatibility. The in vivo results indicated that the hybrid hydrogel accelerated wound healing significantly via comprehensive factors of photodynamic antibiosis of CMCS/Ce6 NPs, cell proliferation promotion by Mg 2+ , good bioadhesion, and moisture retention of the PAM hydrogel, which promoted collagen deposition and blood vessel maturation.

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Self-assembly strategies of organic small-molecule photosensitizers for photodynamic therapy

Cited by 7 publications

References 173 publications

Advancing Two‐Photon Photodynamic Therapy Over NIR‐II Excitable Conjugated Microporous Polymer with NIR‐I Emission

Advancing Two‐Photon Photodynamic Therapy Over NIR‐II Excitable Conjugated Microporous Polymer with NIR‐I Emission

The influence of Fe2+ on the self-assembly of a bipyridine containing homopolymer: From bowl-shaped nanoparticles to vesicles

Hybrid Hydrogels of Polyacrylamide and Self-assembly Photodynamic Nanoparticles with Diverse Adhesion for Infected Chronic Wound Healing

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