Self-association and complexation of triterpene glycosides and cholesterol

Yakovishin, L. A.; Borisenko, N. I.; Rudnev, Misha; Vetrova, E. V.; Гришковец, В. И.

doi:10.1007/s10600-010-9522-8

Cited by 11 publications

(9 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The comparison of the dimensions of CAF molecules with those of zeolite channels and pores: micropores (<1.5 nm) and (ii) mesopores (1.5-16.0 nm), revealed that there were no spatial limitations for the drug molecules to enter the microand mesopores of the zeolitic matrix ( Figure 6). However, a number of scientific investigations revealed the tendency of self-association of CAF molecules, as well as the formation of stable dimers in aqueous solutions, especially at high concentrations [25], involving stacking interactions [26,27]. Consequently, the latter phenomenon could explain the observed lower values of the intraparticle diffusion correlation coefficients and rate constants as compared to those obtained for the PSO model.…”

Section: Host-guest Interactionsmentioning

confidence: 98%

Study on the host-guest interactions during caffeine encapsulation into zeolite

2015

View full text Add to dashboard Cite

The objective of this study was to investigate the equilibrium and kinetics behavior, sorption mechanism and host-guest interactions during caffeine (CAF) encapsulation in natural zeolite. The chemical, spectral and morphological properties of the newly obtained drug-carrier system were analyzed. Zeolite surface chemistry and morphology were characterized by determination of pH of zero charge, FT-IR and digital microscopy analyses. Equilibrium and kinetic sorption experiments and modeling were conducted to assess zeolite potential. Satisfactory extend of CAF encapsulation in the zeolite matrix (E 36.4%) was obtained. The probable host-quest interactions include Van der Waals interactions, H-bonds and chemical interactions between CAF functional groups and zeolite silanol groups, as well as parallel intraparticle diffusion of drug molecules in the mesopores of the mineral particles. The analyses of the experimental results indicated that natural zeolite could be successfully applied for encapsulating CAF.

show abstract

Section: Host-guest Interactionsmentioning

confidence: 98%

Study on the host-guest interactions during caffeine encapsulation into zeolite

2015

View full text Add to dashboard Cite

show abstract

“…Использовали программное обеспечение micrOTOFcontrol Ихтиотоксичность проверяли на рыбах Poecilia sphenops (Poeciliidae) по известной методике. [25] Рыб (по 10 штук) помещали в 10 -4 М растворы GC и β-CD, а также в их комплекс, содержащий по 10 -4 М каждого из компонентов. Определяли время инкубации, в течение которого происходил бы 100 % летальный исход.…”

Section: экспериментальная частьunclassified

Physico-chemical characteristic and biological activity of the supramolecular complex of glycyram with b-cyclodextrin

Yakovishin¹,

Гришковец²,

Корж³

et al. 2015

MHC

View full text Add to dashboard Cite

“…Triterpene glycosides 1 and 2 are characteristic of plants from various species of the genus Hedera L. (ivy) [5] and are ingredients of the cough medicines "Gedeliks" [6,7] and "Prospan" [6,8], which contain extract of H. helix L. leaves. Complexes of 1 with amino acids [9,10], cholesterol [11], and sildenafil [12] were prepared. The reaction of 1 and 2 with caffeine in aqueous solutions was examined [13].…”

mentioning

confidence: 99%