Self-compassion as a predictor of interleukin-6 response to acute psychosocial stress

Breines, Juliana G.; Thoma, Myriam V.; Gianferante, Danielle; Hanlin, Luke; Chen, Xuejie; Rohleder, Nicolas

doi:10.1016/j.bbi.2013.11.006

Cited by 149 publications

(100 citation statements)

References 36 publications

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“…Initial placement of the catheter was followed by a resting period of 30 min to ensure recovery from potential stress response to catheter placement or traveling to the laboratory. Because previous research has found that IL-6 peaks 120 minutes post-stressor (von Kanel, Kudielka et al 2006, Breines, Thoma et al 2014, Rohleder 2014), blood was drawn at baseline, 30, and 120 min following the TSST on both study days.…”

Section: Methodsmentioning

confidence: 99%

Measures of adiposity predict interleukin-6 responses to repeated psychosocial stress

McInnis

Thoma

Gianferante

et al. 2014

Brain, Behavior, and Immunity

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Objective Overweight and obese individuals, who comprise approximately two-thirds of the U.S. population, are at increased risk for developing a range of diseases. This increased risk may be due in part to maladaptive stress responses within this group, including heightened low-grade inflammation and HPA axis non-habituation. In this study we tested the relationship between adiposity, plasma interleukin-6 (IL-6) and HPA axis responses to repeated stress. Methods Sixty-seven healthy participants were exposed to the Trier Social Stress Test (TSST) on two consecutive days. We collected saliva for cortisol measurements at baseline and at 1, 10, 30, 60 and 120 minutes post-TSST, and blood for plasma IL-6 measurements at baseline and 30 and 120 minutes post-TSST. Results Stress exposure induced significant increases of cortisol and IL-6 on both days (cortisol: F=38, p<0.001; IL-6: F=90.8; p<0.001), and repeated exposure was related with cortisol habituation (F=8.2; p<0.001) and IL-6 sensitization (F=5.2; p=0.022). BMI and body fat were related with higher cortisol responses to repeated stress (BMI: beta=0.34; p=0.014; body fat: beta=0.29; p=0.045), and with higher IL-6 responses to repeated stress (BMI: beta=0.27, p=0.044; body fat: beta=0.37; p=0.006). Conclusions Taken together, individuals with higher measures of adiposity showed less efficient HPA axis habituation as well as sensitization of IL-6 responses to repeated acute stress. These findings point to maladaptive stress response patterns in overweight humans, which, through exposure to higher levels of inflammatory mediators, might partially explain diseases related with overweight and/or obesity.

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Section: Methodsmentioning

confidence: 99%

Measures of adiposity predict interleukin-6 responses to repeated psychosocial stress

McInnis

Thoma

Gianferante

et al. 2014

Brain, Behavior, and Immunity

Self Cite

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“…In fact, Breines et al (2014, 2015) reported evidence of this effect. Adults with higher self-compassion exhibited lower interleukin-6 production, an inflammatory marker, and lower salivary alpha amylase production, a marker of sympathetic nervous system activation, in response to the Trier Social Stress Test (TSST), an acute laboratory social stressor which participants generally interpret as threatening to social status (Breines et al, 2014, 2015).…”

Section: Introductionmentioning

confidence: 97%

“…Social support is one mechanism that helps to protect adolescents from these social threats and is linked to healthy adjustment (Hauser & Bowlds, 1990). Self-compassion may be viewed as social support turned inwards (Breines et al, 2014), providing a way in which adolescents can directly support themselves emotionally . Therefore, one would expect that those with higher self-compassion would evidence a diminished physiological stress response in the presence of a social stressor than those with lower self-compassion.…”

Section: Introductionmentioning

confidence: 99%

“…Adults with higher self-compassion exhibited lower interleukin-6 production, an inflammatory marker, and lower salivary alpha amylase production, a marker of sympathetic nervous system activation, in response to the Trier Social Stress Test (TSST), an acute laboratory social stressor which participants generally interpret as threatening to social status (Breines et al, 2014, 2015). Extending these findings, a brief, self-compassion training was reported to buffer effects of the TSST when compared to an attention and no-training control condition (Arch et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Does Self-Compassion Protect Adolescents from Stress?

et al. 2015

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“…For example, individuals with considerably high self-compassion showed substantially low autonomic response and anxiety when they were exposed to acute psychosocial threat (Neff et al, 2007a; Breines et al, 2014). Vettese et al (2011) determined that self-compassion was reported to mediate the relationship between the experience of maltreatment in childhood and later emotion dysregulation.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Self-Compassion to Emotional Response among Students with Chronic Academic Stress

et al. 2016

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The literature has shown that self-compassion is a protective factor of an individual’s emotional response to chronic stress. However, this stress-buffering effect has not been completely analyzed in individuals who report significantly high academic stress. The present study explored the role of self-compassion in a group of undergraduate students who experience chronic academic stress. A total of 208 undergraduate students who were preparing for the Postgraduate Entrance Examination (PEE) were recruited and completed the Self-Compassion Scale, Adolescent Self-Rating Life Event Check List, and Positive and Negative Affect Schedule. Differences analysis confirmed that the participants reported significantly higher academic stress than their peers who were not preparing for PEE. Self-compassion positively related to positive affect but negatively related to negative affect and learning stress. Further analysis showed that self-compassion negatively mediated the relationship between chronic academic stress and negative affect. Findings imply that self-compassion-centered interventions can be developed in the educational context to assist students cope with chronic academic stress.

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Self-compassion as a predictor of interleukin-6 response to acute psychosocial stress

Cited by 149 publications

References 36 publications

Measures of adiposity predict interleukin-6 responses to repeated psychosocial stress

Measures of adiposity predict interleukin-6 responses to repeated psychosocial stress

Does Self-Compassion Protect Adolescents from Stress?

Protective Effect of Self-Compassion to Emotional Response among Students with Chronic Academic Stress

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