“…Nevertheless, current methods including enzyme linked immunosorbent Recently, high electron mobility transistor (HEMT) based biosensors have exhibited their advantages in detecting a variety of chemical and biological substances. Owing to the high sheet concentration of the two-dimensional gas (2DEG) in the channel layer, which is induced by spontaneous and piezoelectric polarization in GaN-based HEMTs [3], [4] and by δ-doping in GaAs, InP, and Sb-based HEMTs [5]- [9], small variation in the charges at the gate area by the presence of the target substance will induce a large change of the current between the source and drain. Using AlGaN/GaN HEMTs, fast detection of DNA, enzyme-based lactic acid, perkinsus marinus, etc., has been reported [10]- [16].…”