Self-crystallisation, an unexpected property of 45S5 Bioglass®

Vukajlovic, Djurdja; Novakovic, Katarina; Bretcanu, Oana

doi:10.1039/d1cc04847c

Cited by 11 publications

(6 citation statements)

References 15 publications

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“…The improvement of the mechanical properties of Ge25%, which was reported that the mechanical properties improve in the crystalline state, makes it a strong candidate for medical applications, which is consistent with the results of the IR for this ratio 50 .…”

Section: Resultssupporting

confidence: 85%

“…The diffraction peaks of SCP confirmed by matching the cards 96-810-3588, 96-231-0557, 96-154-0706 and 96-153-0880 of COD database (Fig. 4 ), also very closed to the reported similar bioglass systems 48 – 50 . GeO 2 peaks matched accurately PDF2 card no 98-005-9625 for GeO 2 .…”

Section: Resultssupporting

confidence: 75%

“…It is noticeable that the bioglass sample (SCP) appears in the crystalline state, although it has not been heated to the crystallization temperature. This can be explained by what has been published about the ability of bioglass to recrystallize itself at room temperature and in ambient conditions 50 . Moreover, the crystallization activity of P 2 O 5 ions 51 .…”

Section: Resultsmentioning

confidence: 95%

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Effect of germanium oxide on the structural aspects and bioactivity of bioactive silicate glass

Tiama

Ibrahim

Sharaf

et al. 2023

Sci Rep

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Ternary silicate glass (69SiO2–27CaO–4P2O5) was synthesized with the sol–gel route, and different percentages of germanium oxide GeO2 (6.25, 12.5, and 25%) and polyacrylic acid (PAA) were added. DFT calculations were performed at the B3LYP/LanL2DZ level of theory for molecular modelling. X-ray powder diffraction (XRPD) was used to study the effect of GeO2/PAA on the structural properties. The samples were further characterized using DSC, ART-FTIR, and mechanical tests. Bioactivity and antibacterial tests were assessed to trace the influence of GeO2 on biocompatibility with biological systems. Modelling results demonstrate that molecular electrostatic potential (MESP) indicated an enhancement of the electronegativity of the studied models. While both the total dipole moment and HOMO/LUMO energy reflect the increased reactivity of the P4O10 molecule. XRPD results confirmed the samples formation and revealed the correlation between the crystallinity and the properties, showing that crystalline hydroxyapatite (HA) is clearly formed in the highest percentages of GeO2, proposing 25% as a strong candidate for medical applications, consistent with the results of mechanical properties and the rest of the characterization results. Simulated body fluid (SBF) in vitro experiments showed promising biocompatibility. The samples showed remarkable antimicrobial and bioactivity, with the strongest effect at 25%. The experimental findings of this study revealed that the incorporation of GeO2 into the glass in terms of structural characteristics, bioactivity, antimicrobial properties, and mechanical properties is advantageous for biomedical fields and especially for dental applications.

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Section: Resultssupporting

confidence: 85%

Section: Resultssupporting

confidence: 75%

Section: Resultsmentioning

confidence: 95%

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Effect of germanium oxide on the structural aspects and bioactivity of bioactive silicate glass

Tiama

Ibrahim

Sharaf

et al. 2023

Sci Rep

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“…These results suggest the combination of both the nanoreinforcements due to the phases and the characteristic mineralogical composition of the MMT-NPs@MgNPs-BV base of Al, Si, P, Na, Mg, F, O, and H …”

Section: Resultsmentioning

confidence: 81%

“…Figure 2 shows the characterizations of the MMT-NPs, MgNPs-BV, and MMT-NPs@MgNPs-BV. According to Figure 2a, the MMT-NPs@MgNPs-BV demonstrated crystalline phases from MMT-NPs and MgNPs-BV, containing peaks in (i) muscovite 2M1 (Al These results suggest the combination of both the nanoreinforcements due to the phases and the characteristic mineralogical composition of the MMT-NPs@MgNPs-BV base of Al, Si, P, Na, Mg, F, O, and H. 15 MMT-NPs@MgNPs-BV obtained a lower d c of around 12.52 nm compared to the phases of 48 nm and 34 nm for MMT-NPs and MgNPs-BV, respectively, and a higher crystallinity at 82.02%. In this sense, the thermal treatment used, 1273.15 K, promoted an increase in the coalescence process, indicating greater organization of atoms, denoting greater mechanical strength, which is necessary for nanoreinforcements in nanocomposites.…”

Section: Resultsmentioning

confidence: 88%

Fabrication and Properties of the Montmorillonite/Nanobioglass Hybrid Reinforcement from Agroindustrial Waste for Bone Regeneration

Druzian,

Bonazza,

Sangoi

et al. 2024

ACS Appl. Mater. Interfaces

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Nowadays, bone systems have a series of consequences that compromise the quality of life mainly due to wear and decreased bioactivity, generally in elderly people and children. In this context, the combination of montmorillonite (MMT-NPs) in a vitreous system such as nanobioglass facilitates the adsorption of biomolecules on the surface and within the interlamellar spaces, enabling the entry of ions by a cation exchange process focusing on increasing the rate of bone formation. This work aims to synthesize and characterize an eco-friendly hybrid reinforcement containing MMT-NPs with nanobioglass doped with magnesium nanoparticles (MgNPs-BV). In this way, MMT-NPs@ MgNPs-BV was synthesized by the impregnation method, where an experimental design was used to verify the synthesis conditions. The ideal condition by experimental design was carried out in terms of the characterization and biological activity, where we demonstrated MMT-NPs of 30% w w −1 , MgNPs-BV of 6% w w −1 , and a calcination temperature of 1273.15 K with a cell viability around 66.87%, an average crystallite diameter of 12.5 nm, and a contact angle of 17.7°. The characterizations confirmed the impregnation method with an average particle size of 51.4 ± 13.1 nm. The mechanical tests showed a hardness of 2.6 GPa with an apparent porosity of 22.2%, similar to human bone. MMT-NPs@MgNPs-BV showed a cell proliferation of around 96% in osteoblastic cells (OFCOL II), with the formation of the apatite phase containing a relation of Ca/P of around 1.63, a biodegradability of 82%, and rapid release of ions with a Ca/P ratio of 1.42. Therefore, the ecofriendly hybrid reinforcement with MMT-NPs and MgNPs-BV shows potential for application with a matrix for biocompatible nanocomposites for bone regeneration.

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Bilayer Scaffolds Synergize Immunomodulation and Rejuvenation via Layer‐Specific Release of CK2.1 and the “Exercise Hormone” Lac‐Phe for Enhanced Osteochondral Regeneration

Liu,

He,

Shen

et al. 2024

Adv Healthcare Materials

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Repairing osteochondral defects necessitates the intricate reestablishment of the microenvironment. The cartilage layer consists of a porous gelatin methacryloyl hydrogel (PGelMA) covalently crosslinked with the chondroinductive peptide CK2.1 via a “linker” acrylate‐PEG‐N‐hydroxysuccinimide (AC‐PEG‐NHS). This layer is optimized for remodeling the senescent microenvironment in the cartilage region, thereby establishing a regenerative microenvironment that supports chondrogenesis. For the bone layer, silk fibroin methacryloyl (SilMA) is coated onto a three dimensional (3D)‐printed 45S5 bioactive glass scaffold (BG scaffold). The “exercise hormone” N‐lactoyl‐phenylalanine (Lac‐Phe) is loaded onto the SilMA, endowing it with diversified functions to regulate the osteogenic microenvironment. Systematic analysis in vitro reveals that PGelMA‐CK2.1 shifts the microenvironment from a pro‐inflammatory into an anti‐inflammatory condition, and alleviates cellular senescence, thus modifying the cartilage microenvironment to improve the recruitment, proliferation and chondral differentiation of bone marrow mesenchymal stem cells (BMSCs). The scaffold bone layer enhances microvascular endothelial cell proliferation, migration, and angiogenic activities, which, couple with increased BMSC recruitment and regulatory mechanisms directing BMSC differentiation, favor a shift in the “osteogenesis–adipogenesis” balance toward enhanced osteogenesis. In vivo, it is found that this biphasic biomimetic scaffold favors simultaneous dual tissue regeneration. This approach facilitates the development of bioactive regenerative scaffolds and holds great potential for clinical application.

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Self-crystallisation, an unexpected property of 45S5 Bioglass®

Abstract: Self-crystallisation of 45S5 Bioglass® was observed at room temperature and atmospheric pressure, without further processing, one year after fabrication.

Cited by 11 publications

References 15 publications

Effect of germanium oxide on the structural aspects and bioactivity of bioactive silicate glass

Effect of germanium oxide on the structural aspects and bioactivity of bioactive silicate glass

Fabrication and Properties of the Montmorillonite/Nanobioglass Hybrid Reinforcement from Agroindustrial Waste for Bone Regeneration

Bilayer Scaffolds Synergize Immunomodulation and Rejuvenation via Layer‐Specific Release of CK2.1 and the “Exercise Hormone” Lac‐Phe for Enhanced Osteochondral Regeneration

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