Self-doped conducting polymers in biomedical engineering: Synthesis, characterization, current applications and perspectives

Imae, Ichiro; Krukiewicz, Katarzyna

doi:10.1016/j.bioelechem.2022.108127

Cited by 9 publications

(8 citation statements)

References 102 publications

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“…The differences in the electronic properties of the polymers [41,90,91] are likely to be related to a subtle combination of the extended conjugation length of the LS polymers produced versus HS polymers; the hierarchical assembly of the polymers (governed by intramolecular and intermolecular interactions) [70,92] ; and the ability of the anionic component of the polymers to serve as a dopant for the polymers (supported by zeta potential measurements), akin to self-doped conducting polymers. [93][94][95][96]…”

Section: Resultsmentioning

confidence: 99%

Phenolic Polymers as Model Melanins

Galeb

Eichhorn

Harley

et al. 2023

Macro Chemistry & Physics

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Melanins are a class of conjugated biopolymers with varying compositions and functions, which have a variety of potential medical and technical applications. Here, this work examines the conjugated polymers derived from a variety of phenolic monomers (catechol (CAT), levodopa (DOPA), and homogentisic acid (HGA)), using a selection of different analytical chemistry techniques to compare their properties with a view to understanding structure-function relations. The polymers display measurable conductivity, with electronic properties tuned by the functional groups pendant on the polymer backbones (which served as dopants) suggesting their potential for application in electronic devices.

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Section: Resultsmentioning

confidence: 99%

Phenolic Polymers as Model Melanins

Galeb

Eichhorn

Harley

et al. 2023

Macro Chemistry & Physics

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“…The polymerization of pyrrole can be carried out using chemical, electrochemical, ultrasonic, electrospinning, and even biotechnological methods with different morphologies ( Figure 2 ), among which chemical oxidation polymerization and electropolymerization are commonly used [ 53 , 54 , 55 , 56 , 57 , 58 , 59 ]. During the synthesis of PPy, the CP is able to carry biomolecules or functional groups for specific biometric functions through physicochemical means [ 60 , 61 ]; i.e., physical adsorption, embedding, affinity, covalent immobilization, etc.…”

Section: Polypyrrole Biosensorsmentioning

confidence: 99%

Application of Polypyrrole-Based Electrochemical Biosensor for the Early Diagnosis of Colorectal Cancer

et al. 2023

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Although colorectal cancer (CRC) is easy to treat surgically and can be combined with postoperative chemotherapy, its five-year survival rate is still not optimistic. Therefore, developing sensitive, efficient, and compliant detection technology is essential to diagnose CRC at an early stage, providing more opportunities for effective treatment and intervention. Currently, the widely used clinical CRC detection methods include endoscopy, stool examination, imaging modalities, and tumor biomarker detection; among them, blood biomarkers, a noninvasive strategy for CRC screening, have shown significant potential for early diagnosis, prediction, prognosis, and staging of cancer. As shown by recent studies, electrochemical biosensors have attracted extensive attention for the detection of blood biomarkers because of their advantages of being cost-effective and having sound sensitivity, good versatility, high selectivity, and a fast response. Among these, nano-conductive polymer materials, especially the conductive polymer polypyrrole (PPy), have been broadly applied to improve sensing performance due to their excellent electrical properties and the flexibility of their surface properties, as well as their easy preparation and functionalization and good biocompatibility. This review mainly discusses the characteristics of PPy-based biosensors, their synthetic methods, and their application for the detection of CRC biomarkers. Finally, the opportunities and challenges related to the use of PPy-based sensors for diagnosing CRC are also discussed.

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“…The rapid development of polymeric semiconducting materials for organic electronics is motivated by their pronounced advantages over other type of materials, such as low cost, easy molecular modifications, unique mechanical properties in terms of flexibility and stretchability, 1-3 materials availability, biocompatibility, [4][5][6] and high solubility, which allows the use of a numerous processing conditions. [7][8][9] In the search of efficient polymeric materials for organicelectronics, synthesis of donor-acceptor conjugated polymers has been the most widely approach utilized to date.…”

Section: Introductionmentioning

confidence: 99%