Self-emulsification in chemical and pharmaceutical technologies

Cholakova, Diana; Vinarov, Zahari; Denkov, Nikolai

doi:10.1016/j.cocis.2022.101576

Cited by 27 publications

(20 citation statements)

References 135 publications

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“…The spontaneous method is also regarded as the titration method. This method is easy to follow as nanoemulsion is formed by mixing all ingredients in the right proportion with continuous agitation [65]. The spontaneous method currently prepares all forms of nanoemulsion, such as gel and liquid having high flow rates, etc.…”

Section: Current Trends In Nanoemulsions Applications and Formulationmentioning

confidence: 99%

Recent Developments in Nano-Emulsions’ Preparatory Methods and their Applications: A Concise Review

Rehman

Younas

Bano³

et al. 2022

Pak J Anal Environ Chem

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Nano-emulsion is one of the most effective and size-controlled mediums for effective drug delivery systems, the formation of cosmetics products, food preservatives, and insecticidal and antimicrobial products. Therefore, a durable and sophisticated approach is primely important in preparing effective nano-emulsions. Some of the established fabrication approaches towards nanoemulsion are the high and low-energy methods. Depending upon the required results of formulations, these two methods are further divided into sub-categories such as ultra-sonicators, micro-fluidizers, high-pressure homogenizers, phase inversion temperature, phase inversion composition, etc. This review highlights all the available methods to form nano-emulsion by adopting high-energy and low-energy techniques. In addition, this review also elaborates on the importance of nano-emulsions in various end products, as nano-carriers and patents have also been awarded in this field. Besides, the required improvements in this field have been discussed briefly to establish the most authentic approach toward nano-emulsion formation.

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Section: Current Trends In Nanoemulsions Applications and Formulationmentioning

confidence: 99%

Recent Developments in Nano-Emulsions’ Preparatory Methods and their Applications: A Concise Review

Rehman

Younas

Bano³

et al. 2022

Pak J Anal Environ Chem

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“…4,5 It is known that stable nanoemulsions with a small droplet size can be produced by spontaneous emulsification by mixing and gradually adding water phase to the oil/surfactant mixture at constant temperature. 2,6,7 As has been known for centuries, herbal materials and essential oils are used for the prevention and treatment of various diseases. Also, their products, such as essential oils, have broad biological activities such as antimicrobial, antioxidant, anti-inflammatory, analgesic, mucolytic, and stimulant.…”

Section: Introductionmentioning

confidence: 99%

“…Considering the solubility, W/O and O/W nanoemulsions are better for hydrophilic and lipophilic drugs, respectively. In recent years, O/W nanoemulsions are used in health, cosmetics, food, agricultural chemistry, pharmaceuticals, and biotechnology, among other sectors. , It is known that stable nanoemulsions with a small droplet size can be produced by spontaneous emulsification by mixing and gradually adding water phase to the oil/surfactant mixture at constant temperature. ,, …”

Section: Introductionmentioning

confidence: 99%

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Enhanced Bioactivity of Rosemary, Sage, Lavender, and Chamomile Essential Oils by Fractionation, Combination, and Emulsification

et al. 2023

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This study aimed to increase the bioactivity of essential oils by fractionation, combination, and emulsification. In this regard, pharmaceutical quality Rosmarinus officinalis L. (rosemary), Salvia sclarea L. (clary sage), Lavandula latifolia Medik. (spike lavender), and Matricaria chamomilla L. (chamomile) essential oils were fractionated by vacuum-column chromatography. The main components of the essential oils were verified, and their fractions were characterized by thin layer chromatography, gas chromatography-flame ionization detector, and gas chromatography/mass spectrometry. Besides, oil-in-water (O/W) emulsions of essential oils and diethyl ether fractions were obtained by the self-emulsification method, followed by droplet size, polydispersity index, and zeta potential value measurements. The in vitro antibacterial effects of the emulsions and binary combinations (10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10, v:v) against Staphylococcus aureus were determined by microdilution. In addition, the in vitro anti-biofilm, antioxidant, and anti-inflammatory effects of emulsion formulations were evaluated. According to the experimental results, fractionation and emulsification enhanced essential oil in vitro antibacterial, anti-inflammatory, and antioxidant effects due to increased solubility and nano-sized droplets. Among 22 different emulsion combinations, 1584 test concentrations resulted in 21 cases of synergistic effects. The mechanism of the increase in biological activities was hypothesized to be higher solubility and stability of the essential oil fractions. Food and pharmaceutical industries may benefit from the procedure proposed in this study.

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“…SEFs consist of oils, surfactants, and co-surfactants with suitable compositions to form a stable mixture (Cholakova et al, 2022;Shiyan et al, 2022). SEFs emulsify spontaneously in the GI tract and effectively increase bioavailability (Cardona et al, 2021;Dhritlahre et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Response Corellation Using Chemometrics Analysis for Pre-Optimization Quercetin – Self Emulsion Formulation

Shiyan

Pratiwi³

2022

JFSP

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The optimization approach using the simplex lattice design (SCD) has many advantages, including a minimized number of experiments and a good description of the interactions between components. However, modeling with the SCD approach has not evaluated between responses. Therefore, this study aims to apply chemometric analysis to evaluate the response from the optimization stage using the quercetin – self emulsion formulations (quercetin-SEFs) as a model. SEFs were prepared using grapeseed oil, croduret, and PEG 400. The evaluated responses included emulsification time and transmittance. Both responses were developed in endurance test by centrifugation method and stability test using freeze-thaw. Chemometric analysis on CA produced a dendrogram, while PCA produced score plots, loading plots, scree plots, and biplots. Emulsification time has a positive correlation with transmittance value. The quercetin-SEFs formula in SCD was classified into three groups based on the similarity of characters. Chemometric analysis was successfully applied in evaluating the response to the quercetin-SEFs optimization modeling.

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Self-emulsification in chemical and pharmaceutical technologies

Cited by 27 publications

References 135 publications

Recent Developments in Nano-Emulsions’ Preparatory Methods and their Applications: A Concise Review

Recent Developments in Nano-Emulsions’ Preparatory Methods and their Applications: A Concise Review

Enhanced Bioactivity of Rosemary, Sage, Lavender, and Chamomile Essential Oils by Fractionation, Combination, and Emulsification

Evaluation of Response Corellation Using Chemometrics Analysis for Pre-Optimization Quercetin – Self Emulsion Formulation

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