2014
DOI: 10.1002/jps.23919
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Self-Emulsifying Pellets: Relations Between Kinetic Parameters of Drug Release and Emulsion Reconstitution—Influence of Formulation Variables

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Cited by 14 publications
(23 citation statements)
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“…The molecular size of drugs is similar (330.8 and 259.3), but they have different lipophilicities (log P 2.0 and 3.5, respectively) and different solubilities in the oil/surfactant mixtures (24.7-63.2 mg/mL; ref. 22). Therefore, the drugs are expected to be distributed differently between the droplets and the external aqueous phase (15).…”
Section: Resultsmentioning
confidence: 99%
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“…The molecular size of drugs is similar (330.8 and 259.3), but they have different lipophilicities (log P 2.0 and 3.5, respectively) and different solubilities in the oil/surfactant mixtures (24.7-63.2 mg/mL; ref. 22). Therefore, the drugs are expected to be distributed differently between the droplets and the external aqueous phase (15).…”
Section: Resultsmentioning
confidence: 99%
“…For the preparation of pellets by extrusion/spheronization, 30 g batches of MCC powder were mixed with 30 g emulsions (75% water and 25% w/w oil/surfactant/drug self-emulsifying mixture) for about 5 min in a 1-L cylindrical mixing vessel, fitted with a three-blade impeller (22). The emulsions had milky appearance except for those containing FS and oil/surfactant ratio 1.5, which gave clear (RH40) or slightly turbid, translucent emulsions.…”
Section: Pellet Preparation and Characterizationmentioning
confidence: 99%
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