Self-Emulsifying Systems for Delivery of Bioactive Compounds from Natural Origin

Bruschi, Marcos Luciano

doi:10.1208/s12249-022-02291-z

Cited by 8 publications

(8 citation statements)

References 131 publications

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“…For the preparation of systems to transport these compounds, physicochemical approaches and innovations are required. SEDDS have been employed as carriers of hydrophobic chemicals to improve their parameters like solubility and absorption, and bioavailability (de Oliveira & Bruschi, 2022 ).…”

Section: Benefits Of Sedds As Compared To Conventional Emulsionmentioning

confidence: 99%

“…When designing SEDDS/SMEDDS that utilize various excipients, overall solubilizing power of the system should be focused rather than the solubility of the drug in the individual components, even though assessment of affinity and solubility of the drug for each component is essential. Surfactant, co-surfactant, and oil phase components might be synthetic, semi-synthetic, or natural but components are chosen because of (1) attaining maximum loading of drug, (2) to ensure maximum absorption, duration of self-emulsification and droplet size must be kept to a minimum in the gastric environment, (3) to decrease droplet size of emulsion, fluctuation as a function of aqueous medium pH and electrolyte concentration, and (4) to avoid/reduce medication degradation/metabolism in the physiological environment (Rahman et al., 2013 ; Badadhe & Dalavi, 2022 ; de Oliveira & Bruschi, 2022 ).…”

Section: Benefits Of Sedds As Compared To Conventional Emulsionmentioning

confidence: 99%

“…The most significant factors for optimizing oral therapeutic effectiveness are pharmaceutical ingredient solubility, dissolution rate, and permeability (Sirvi et al., 2022 ). SEDDS' dissolution rate is also an essential characteristic since it can alter medication release kinetics and gastrointestinal absorption (de Oliveira & Bruschi, 2022 ). The water solubility and gastrointestinal permeability are the categories of API as described by the BCS (Amidon et al., 1995 ).…”

Section: Solubility Of Active Drug In Seddsmentioning

confidence: 99%

“…The resultant combinations can be integrated into the lipophilic phase of SEDDS because of hydrophobic ion pairing (HIP) with charged auxiliary agents that is lipophilic in nature. By utilizing auxiliary agents in suitable proportions for the HIP, drug release was deliberately modified according to the solubility of the compound in the SEDDS pre-concentrate and the release matrix (de Oliveira & Bruschi, 2022 ). Based on the target region, the oily droplets might be either mucoadhesive or very mucus permeable.…”

Section: Introductionmentioning

confidence: 99%

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Self-emulsifying drug delivery systems: a novel approach to deliver drugs

Salawi

2022

Drug Delivery

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Self-emulsifying drug delivery systems (SEDDS) are a proven method for poorly soluble substances works by increasing the solubility and bioavailability. SEDDS and isotropic mixtures, are composed of oils, surfactants, and occasionally cosolvents. The ability of these formulations and methods to produce microemulsions or fine oil-in-water (o/w) emulsions after moderate stirring and dilution by water phase along the GI tract might be a promising technique for lipophilic agents with dissolution rate-limited absorption. This review provides an outline of SEDDS's numerous advances and biopharmaceutical elements, types, manufacturing, characterization, limitations, and future prospects. The evaluation of SEDDS and its applications are also discussed, focusing on the advances of SEDDS's solid self-emulsifying delivery mechanism and dosage form. By integrating suitable polymer into the formulation, SEDDS may be studied for the creation of a formulation with sustained drug release. This technology's improvement might lead to a new application in the field of medicine delivery. SEDDS has been demonstrated to be quite efficient in increasing oral bioavailability of lipophilic products. SEDDS is one of the promising methods for controlling the characteristics of medications that are not great choices for oral delivery. It is also worth mentioning that SEDDS may be made in variety of solid dosage forms that are acceptable for both oral and parenteral administration.

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Section: Benefits Of Sedds As Compared To Conventional Emulsionmentioning

confidence: 99%

Section: Benefits Of Sedds As Compared To Conventional Emulsionmentioning

confidence: 99%

Section: Solubility Of Active Drug In Seddsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Self-emulsifying drug delivery systems: a novel approach to deliver drugs

Salawi

2022

Drug Delivery

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“…Initially, resistance to new drugs was just 1%. However, current extensive antibiotic use has caused a significant escalation in the number of antibiotic‐resistant microbes 4 …”

Section: Introductionmentioning

confidence: 99%

Reshaping antibiotic delivery: Chitosan‐based polymeric hydrogel for transdermal treatment of drug resistant bacteria

Tariq,

Kazim,

Khan

et al. 2024

Polymers for Advanced Techs

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The aim of the present study was to formulate and assess the antibacterial efficacy of a transdermal chitosan based polymeric hydrogel for transdermal treatment of bacterial resistance strains. Utilizing the micro‐emulsion method and the Box–Behnken design model, imipenem‐cilastatin (IMI‐CIL) loaded nanostructured lipid carriers (NLCs) were fabricated and optimized, employing Compritol 888 ATO as the lipid core and Tween 80 as the stabilizer. The optimized nanoformulation underwent a comprehensive evaluation encompassing parameters such as particle diameter, zeta potential, surface morphology, entrapment efficiency, crystallinity, and molecular interaction. The optimized nanoparticles displayed a mean particle size of 129 nm, a zeta potential of −19.8 mV, and a polydispersity index (PDI) of 0.286. Detailed investigations into crystallinity and Fourier transform infrared (FTIR) analysis did not reveal any indications of molecular interaction. Both the IMI‐CIL loaded NLCs and the hydrogel exhibited sustained in‐vitro drug release. Moreover, the hydrogel, enriched with permeation enhancers, demonstrated a remarkable 15.77‐fold increase in drug permeation. Furthermore, the IMI‐CIL loaded NLCs exhibited significantly elevated antibacterial activity when juxtaposed with IMI‐CIL solution, which demonstrated minimal activity against non‐resistant bacterial species and lacked activity against resistant isolates. In summary, the IMI‐CIL loaded NLCs hydrogel formulation assumes a pivotal role in bestowing sustained drug release and augmenting the antibacterial efficacy of carbapenem antibiotics. This holds promise as a potential solution to combat drug‐resistant bacterial infections.

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