Self-expandable metal stents in malignant biliary obstruction: Back to the roots with uncovered stents as the “new” standard?

Beyna, Tors﻿ten; Neuhaus, Horst

doi:10.1016/j.gie.2017.11.022

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…Of note, Wang and colleagues developed partially covered nitinol stents loaded with 5-fluorouracil or paclitaxel for esophageal cancer and found severe tissue responses, including inflammation, ulceration, and granulation, at the bare ends compared to the drug-loaded part in porcine esophageal tissues[ 25 ]. Since partially covered stents have not yet been proven to be effective in the prevention of stent migration for malignant biliary strictures and still need to be further evaluated in clinical trials[ 38 , 39 ], in our study, we used a fully covered stent design to alleviate tissue responses.…”

Section: Discussionmentioning

confidence: 99%

Feasibility and efficacy evaluation of metallic biliary stents eluting gemcitabine and cisplatin for extrahepatic cholangiocarcinoma

Xiao

Weng

et al. 2020

WJG

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BACKGROUND Effective endoscopic management is fundamental for the treatment of extrahepatic cholangiocarcinoma (ECC). However, current biliary stents that are widely used in clinical practice showed no antitumor effect. Drug-eluting stents (DESs) may achieve a combination of local chemotherapy and biliary drainage to prolong stent patency and improve prognosis. AIM To develop novel DESs coated with gemcitabine (GEM) and cisplatin (CIS)-coloaded nanofilms that can maintain the continuous and long-term release of antitumor agents in the bile duct to inhibit tumor growth and reduce systemic toxicity. METHODS Stents coated with different drug-eluting components were prepared by the mixed electrospinning method, with poly-L-lactide-caprolactone (PLCL) as the drug-loaded nanofiber membrane and GEM and/or CIS as the antitumor agents. Four different DESs were manufactured with four drug-loading ratios (5%, 10%, 15%, and 20%), including bare-loaded (PLCL-0), single-drug-loaded (PLCL-GEM and PLCL-CIS), and dual-drug-loaded (PLCL-GC) stents. The drug release property, antitumor activity, and biocompatibility were evaluated in vitro and in vivo to confirm the feasibility and efficacy of this novel DES for ECC. RESULTS The in vitro drug release study showed the stable, continuous release of both GEM and CIS, which was sustained for over 30 d without an obvious initial burst, and a higher drug-loaded content induced a lower release rate. The drug-loading ratio of 10% was used for further experiments due to its ideal inhibitory efficiency and relatively low toxicity. All drug-loaded nanofilms effectively inhibited the growth of EGI-1 cells in vitro and the tumor xenografts of nude mice in vivo ; in addition, the dual-loaded nanofilm (PLCL-GC) had a significantly better effect than the single-drug-loaded nanofilms ( P < 0.05). No significant differences in the serological analysis ( P > 0.05) or histopathological changes were observed between the single-loaded and drug-loaded nanofilms after stent placement in the normal porcine biliary tract. CONCLUSION This novel PLCL-GEM and CIS-eluting stent maintains continuous, stable drug release locally and inhibits tumor growth effectively in vitro and in vivo . It can also be used safely in normal porcine bile ducts. We anticipate that it might be considered an alternative strategy for the palliative therapy of ECC patients.

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Section: Discussionmentioning

confidence: 99%

Feasibility and efficacy evaluation of metallic biliary stents eluting gemcitabine and cisplatin for extrahepatic cholangiocarcinoma

Xiao

Weng

et al. 2020

WJG

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“…As próteses metálicas devem ser a primeira escolha para pacientes com expectativa de vida superior a 4 meses, uma vez que nesse período seria necessário ao menos duas próteses plásticas, implicando em similaridade no seu custo (FRANCO, 2015;BEYNA;NEUHAUS, 2018).…”

Section: A Escolha Da Próteseunclassified

As Interfaces Produzidas Pela Ambiência Em Uma Unidade Básica De Saúde Em Cidade De Médio Porte No Interior De Minas Gerais

Neiva¹,

Delboni²,

Roque³

et al. 2021

A Medicina Imersa Em Um Mundo Globalizado Em Rápida Evolução 2

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Direitos para esta edição cedidos à Atena Editora pelos autores.Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons.Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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“…They are primarily preferred in malignant diseases of the biliary tree. Metallic stenting is performed in the palliation of jaundice secondary to cholangiocarcinoma, gallbladder, pancreas, ampulla of water, liver cancer and metastatic biliary tract tumors [3,4]. They promise a wider and longer lumen opening compared to plastic stents [5].…”

Section: Metallic Stentsmentioning

confidence: 99%

Biliary stents: models and advancements

Kosekl¹

2021

2791-6332

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Obesity and sedentary lifestyle increase the formation of stones in the biliary tract. Choledochal stent placement with endoscopic intervention in cases of choledochal stones and bile leakage has been a common procedure in gastroenterology practice in recent years. Intervention for post-op biliary strictures is increasing in parallel with the number of liver transplantations. Stent placement procedures for palliation of primary or metastatic malignant processes of the biliary tract also contribute to the comfort of life of patients. In this article, brief information about the stents used in the biliary system is presented.

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Self-expandable metal stents in malignant biliary obstruction: Back to the roots with uncovered stents as the “new” standard?

Cited by 7 publications

References 20 publications

Feasibility and efficacy evaluation of metallic biliary stents eluting gemcitabine and cisplatin for extrahepatic cholangiocarcinoma

Feasibility and efficacy evaluation of metallic biliary stents eluting gemcitabine and cisplatin for extrahepatic cholangiocarcinoma

As Interfaces Produzidas Pela Ambiência Em Uma Unidade Básica De Saúde Em Cidade De Médio Porte No Interior De Minas Gerais

Biliary stents: models and advancements

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