Self-fitting shape memory polymer foam inducing bone regeneration: A rabbit femoral defect study

Xie, Ruiqi; Hu, Jinlian; Hoffmann, Oskar; Zhang, Yuanchi; Ng, Frankie; Qin, Tingwu; Guo, Xia

doi:10.1016/j.bbagen.2018.01.013

Cited by 70 publications

(54 citation statements)

References 43 publications

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“…The MOSD comprises a spiral shape-memory fiber to serve as a backbone and multiple mini-LEDs. Polyurethane fiber is a heat-induced shape-memory polymer and has been extensively used as a clinical material for fillers and brackets because of its shape-memory property 31–33 , bio-compatibility 34–38 , and mechanical compatibility with meniscus and parenchyma tissue 39 . The original shape of the fiber is straight.…”

Section: Resultsmentioning

confidence: 99%

A shape-memory and spiral light-emitting device for precise multisite stimulation of nerve bundles

Zheng

Zhang

et al. 2019

Nat Commun

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We previously demonstrated that for long-term spastic limb paralysis, transferring the seventh cervical nerve (C7) from the nonparalyzed side to the paralyzed side results in increase of 17.7 in Fugl-Meyer score. One strategy for further improvement in voluntary arm movement is selective activation of five target muscles innervated by C7 during recovery process. In this study, we develop an implantable multisite optogenetic stimulation device (MOSD) based on shape-memory polymer. Two-site stimulation of sciatic nerve bundles by MOSD induces precise extension or flexion movements of the ankle joint, while eight-site stimulation of C7 nerve bundles induce selective limb movement. Long-term implant of MOSD to mice with severed and anastomosed C7 nerve is proven to be both safe and effective. Our work opens up the possibility for multisite nerve bundle stimulation to induce highly-selective activations of limb muscles, which could inspire further applications in neurosurgery and neuroscience research.

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Section: Resultsmentioning

confidence: 99%

A shape-memory and spiral light-emitting device for precise multisite stimulation of nerve bundles

Zheng

Zhang

et al. 2019

Nat Commun

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“…131 Frequently, NiTi SMAs are manipulated to the desired shape in vitro and then applied in vivo, e.g., as bone distractor. [132][133][134] In a recent study, a NiTi-SMA plate was heated by electromagnetic stimulation, yielding higher material stiffness, which in turn resulted in increased fixation stiffness and resulted in better bone healing in a rabbit osteotomy model. 135 Importantly, NiTi SMAs have already been used clinically, including in patients with cleft lip and palate, 136 in patients undergoing midfoot or hindfoot arthrodesis, 136 in treating adolescent idiopathic scoliosis, 137 etc.…”

Section: Piezoelectric Materialsmentioning

confidence: 99%

On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

et al. 2021

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The demand for biomaterials that promote the repair, replacement, or restoration of hard and soft tissues continues to grow as the population ages. Traditionally, smart biomaterials have been thought as those that respond to stimuli. However, the continuous evolution of the field warrants a fresh look at the concept of smartness of biomaterials. This review presents a redefinition of the term “Smart Biomaterial” and discusses recent advances in and applications of smart biomaterials for hard tissue restoration and regeneration. To clarify the use of the term “smart biomaterials”, we propose four degrees of smartness according to the level of interaction of the biomaterials with the bio-environment and the biological/cellular responses they elicit, defining these materials as inert, active, responsive, and autonomous. Then, we present an up-to-date survey of applications of smart biomaterials for hard tissues, based on the materials’ responses (external and internal stimuli) and their use as immune-modulatory biomaterials. Finally, we discuss the limitations and obstacles to the translation from basic research (bench) to clinical utilization that is required for the development of clinically relevant applications of these technologies.

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“…It is the need of the hour to conduct long term research using animal models in order to find the clinical feasibility and use these materials for practical bone tissue engineering applications. Similarly, Xie and coworkers [48] utilized hydroxyapatite (HA) nanoparticles in the fabrication of SMP foam using gas foaming technique for the treatment of load bearing bone defects. Chemical similarity to natural bone matrix (~69 wt % HA) [49] make HA exhibit strong affinity toward host hard tissues.…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

“…Schematic representation of self-fitting shape memory polymer foam as scaffold for bone regeneration and growth after surgery[48].…”

mentioning

confidence: 99%

Shape Memory Polyurethane and its Composites for Various Applications

2019

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The inherent capability to deform and reform in a predefined environment is a unique property existing in shape memory polyurethane. The intrinsic shape memory ability of the polyurethane is due to the presence of macro domains of soft and hard segments in its bulk, which make this material a potential candidate for several applications. This review is focused on manifesting the applicability of shape memory polyurethane and its composites/blends in various domains, especially to human health such as shielding of electromagnetic interference, medical bandage development, bone tissue engineering, self-healing, implants development, etc. A coherent literature review highlighting the prospects of shape memory polyurethane in versatile applications has been presented.

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Self-fitting shape memory polymer foam inducing bone regeneration: A rabbit femoral defect study

Cited by 70 publications

References 43 publications

A shape-memory and spiral light-emitting device for precise multisite stimulation of nerve bundles

A shape-memory and spiral light-emitting device for precise multisite stimulation of nerve bundles

On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

Shape Memory Polyurethane and its Composites for Various Applications

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